Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats

Saravanan, G.; Ponmurugan, P.

doi:10.1016/j.cbi.2010.10.001

Cited by 74 publications

(48 citation statements)

References 33 publications

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“…Under chronic hyperglycemia, reactive oxygen species production is accelerated, which may cause a decreased level of cellular antioxidant enzymes (SOD, Catalase and GPx), thus depromoting the development of antioxidant system (Saravanan & Ponmurugan, 2011). This coincides well with the exemplary biochemical signs of diabetes, such as fatigued soldiers of inherent antioxidant army like SOD and catalase.…”

Section: Discussionmentioning

confidence: 95%

“…S-allylcysteine (SAC), the most abundant organosulfur compound derived from garlic (Allium sativum, Liliaceae), has multiple beneficial effects, such as cholesterol-lowering action and antioxidant and radical scavenging effects (Broek, 2001). In our previous report on the efficacy of SAC in treating diabetes, we investigated the antihyperglycemic (Saravanan, Ponmurugan, Senthil kumar, & Rajarajan, 2009a), lipid modulating (Saravanan & Ponmurugan, 2010), and antioxidant effects of SAC (Saravanan & Ponmurugan, 2011). SAC also reverses the changes in the levels of the carbohydrate metabolizing enzymes (Saravanan, Ponmurugan, Senthil kumar, & Rajarajan, 2009b).…”

Section: Introductionmentioning

confidence: 98%

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Antidiabetic effect of S-allylcysteine: Effect on Thyroid hormone and circulatory antioxidant system in experimental diabetic rats

Saravanan¹,

Ponmurugan²

2012

Journal of Diabetes and its Complications

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Antidiabetic effect of S-allylcysteine: Effect on Thyroid hormone and circulatory antioxidant system in experimental diabetic rats

Saravanan¹,

Ponmurugan²

2012

Journal of Diabetes and its Complications

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“…Many studies have investigated the healing potential of particular agents in animal models of diabetes, examining clinical effects or histological outcomes (24)(25)(26)(27). ABS has been used as a local haemostatic agent in surgery, but it was also shown to promote healing (5,9).…”

Section: Discussionmentioning

confidence: 99%

Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

Aktop¹,

Çevreli²,

Genç³

et al. 2017

Turk J Med Sci

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IntroductionDiabetes mellitus (DM) is a chronic, life-long metabolic disease occurring worldwide. Affected individuals require continuous follow-up and suffer numerous disease-related complications. The high levels of blood glucose that characterise DM contribute to an increase in free radical production, enhanced oxidative stress, and changes in antioxidant capacity (1-3).Streptozotocin (STZ) is the chemical agent most frequently used to induce experimental diabetes in animal models. By binding to glucose receptors in the plasma membrane, STZ blocks glucose-induced insulin secretion (2,3) and alters blood insulin and glucose concentrations.Among the many effects of free radical production is lipid peroxidation (LPO). Oxidation of membrane polyunsaturated fatty acids disrupts cell structure and function and induces cytotoxic, hepatotoxic, mutagenic, and genotoxic effects related to the release of aldehydes (4,5).The tripeptide glutathione (GSH) is found in the cells of all organisms. In humans, GSH concentrations are highest in the liver; in hepatocytes, GSH accounts for 90% of nonprotein sulfhydryl groups. As an important reducing agent and antioxidant, GSH maintains the cellular oxidoreduction balance and protects cells against the toxic effects of oxidants, whether of endogenous or exogenous origin (5-7).Ankaferd BloodStopper (ABS) (Ankaferd Health Products Ltd., İstanbul, Turkey) is a medicinal extract from the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica (7,8). ABS is not only an effective haemostatic agent but also Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods:The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = 12). Four days prior to surgery, rats in the STZ group were subcutaneously administered 60 mg/kg STZ intraperitoneally, while rats in the control group were administered 1 mL saline/kg. An incision was made in the dorsal dermal tissue of all rats, and either ABS or no haemostatic agent (NHAA) was applied to the wound before suturing. All of the rats were euthanised on postoperative day 4. Blood and skin samples were evaluated biochemically and histologically. Results:The results showed that STZ treatment impaired soft-tissue healing, assessed by measuring glutathione and lipid peroxidation levels. Moreover, while good histological results were obtained in the control group treated with ABS, there were fewer benefits in the STZ-treated group. Conclusion:AB...

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“…Its main characteristic is unsuitable hyperglycemia and disordered metabolism of the lipid, charbohydrate, and protein that are caused by insulin deficiency or insulin action or both [1], which contributes to rise in free radical generation [2]. Oxidative stress plays a crucial role in chronic complications of diabetes and it is associated with increased lipid peroxidation [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of Pomegranate on Histopathology of Liver and Kidney on Generated Oxidative Stress Diabetic Induced Rats

Rahmat¹

2015

J Cytol Histol

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Oxidative stress has been recommended as a contributory factor in complication and progression of diabetes. The aim of the study was to evaluate the effects of pomegranate on body weight and histopathology of the steptozotocin-nicotiamide (STZ-NA) generated oxidative stress induced diabetic rats. Thirty-two male SpragueDawley rats were randomly divided into non-diabetic, diabetic untreated and diabetic treated with pomegranate and Glibenclamide. Experimental diabetes was induced by a single intraperitoneal (i.p) administration of STZ 60 mg/kg body weight (b.w), 15 minutes after the i.p injection of NA (120 mg/kg b.w). Histopathological analyses were conducted on the liver and kidney tissues. While the body weight significantly decreased in the diabetic control group, however it was a significant increase in the diabetic treated group (P<0.05). Destruction of the liver architecture of the hepatocytes in the diabetic group showed the signs of necrosis, degeneration, dilatation, and inflammation in the central vein and blood vessels. In the kidney, shrinkage and lesion in Bowman's capsule were observed. Pomegranate acted as an antioxidant thereby preventing oxidative damage in the diabetic liver and kidney.

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Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats

Cited by 74 publications

References 33 publications

Antidiabetic effect of S-allylcysteine: Effect on Thyroid hormone and circulatory antioxidant system in experimental diabetic rats

Antidiabetic effect of S-allylcysteine: Effect on Thyroid hormone and circulatory antioxidant system in experimental diabetic rats

Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

Effect of Pomegranate on Histopathology of Liver and Kidney on Generated Oxidative Stress Diabetic Induced Rats

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