Antidiabetic effect of S-allylcysteine: Effect on Thyroid hormone and circulatory antioxidant system in experimental diabetic rats

Saravanan, G.; Ponmurugan, P.

doi:10.1016/j.jdiacomp.2012.03.024

Cited by 38 publications

(14 citation statements)

References 35 publications

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“…good agreement with the results obtained by the other authors concerning functional disturbances in the HPT axis in experimental DM1 [11][12][13][14][15]25]. Of note is the fact that most studies were carried out on rats with acute DM1 induced by a high dose of STZ (55-75 mg/kg), which is characterized by absolute insulin deficiency, severe hyperglycemia and intoxication, typical of this model.…”

Section: Endocrine Researchsupporting

confidence: 89%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

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The functions of hypothalamic-pituitary-thyroid axis are attenuated in type 1 diabetes mellitus due to insulin deficiency. The use of intranasally administered insulin is of considerable interest for treatment of diabetes and cognitive disorders, but its effect on the thyroid system has not been investigated yet. We studied the influence of long-term treatment with intranasal insulin on the hypothalamic-pituitary-thyroid axis of nondiabetic rats and diabetic animals with streptozotocin models of acute and mild type 1 diabetes mellitus. This treatment was carried out for 28 days in acute (daily does of 0.3, 0.6, and 1.5?IU of insulin per rat) and for 135 days in mild diabetes (daily dose of 0.45?IU/rat). Nondiabetic rats were treated in a similar manner. Intranasal insulin in both models of diabetes resulted in the improvement of thyroid status; manifested as increase of thyroid hormones levels and restoration of response to thyroliberin. In acute diabetes, a daily dose of 0.6?IU/rat was the most effective. Twenty eight days treatment of nondiabetic rats with intranasal insulin at a dose of 0.3?IU/rat resulted in a significant increase of free and total thyroxine levels. Longer treatment of rats with mild diabetes and nondiabetic animals significantly increased thyrotropin level. Thus, long-term intranasal insulin treatment restored the hypothalamic-pituitary-thyroid axis function in type 1 diabetes, but led to a significant increase in the thyrotropin level, which must be considered when designing a strategy for the use of intranasal insulin in clinical applications.

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Section: Endocrine Researchsupporting

confidence: 89%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

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“…In streptozotocin-induced diabetic rats, TSH and thyroid hormone levels decreased, along with circulating catalase (CAT), GSH, glutathione peroxidase (GPx), superoxide dismutase (SOD) and insulin levels. Treatment with SAC reversed these effects and could be used to restore antioxidant capacity, reduce lipid peroxidation and preserve thyroid function in diabetic subjects [177].…”

Section: Effects Of Sulfur-containing Compounds On the Nrf2 Pathway Amentioning

confidence: 99%

Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway

Paunkov

Chartoumpekis

Ziros

et al. 2019

CPD

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Background: Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or treat various diseases. Many of these compounds can activate the cytoprotective Nrf2 pathway. Besides, some of them are known to impact the thyroid gland, often with potential side-effects, but in other instances, with potential utility in the treatment of thyroid disorders. Objective: In view of recent data regarding the multiple roles of Nrf2 in the thyroid, this review summarizes the current bibliography on natural compounds that can have an effect on thyroid gland physiology and pathophysiology, and it discusses the potential implication of the Nrf2 system in the respective mechanisms. Method & Results: Literature searches for articles from 1950 to 2018 were performed in PubMed and Google Scholar using relevant keywords about phytochemicals, Nrf2 and thyroid. Natural substances were categorized into phenolic compounds, sulfur-containing compounds, quinones, terpenoids, or under the general category of plant extracts. For individual compounds in each category, respective data were summarized, as derived from in vitro (cell lines), preclinical (animal models) and clinical studies. The main emerging themes were as follows: phenolic compounds often showed potential to affect the production of thyroid hormones; sulfur-containing compounds impacted the pathogenesis of goiter and the proliferation of thyroid cancer cells; while quinones and terpenoids modified Nrf2 signaling in thyroid cell lines. Conclusion: Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.

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“…Indeed, hyperglycemia causes overproduction of mitochondrial superoxides that ultimately leads to oxidative stress in a variety of tissues (Yu et al, 2006). The modulation of reactive oxygen species (ROS) concentration often generated in hyperglycemic condition by dietary treatment may contribute to the prevention of diabetic complications (Saravanan & Ponmurugan, 2012).…”

Section: Introductionmentioning

confidence: 99%

Garcinia kolaseed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats

Adedara

Awogbindin

Anamelechi

et al. 2014

Pharmaceutical Biology

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Antidiabetic effect of S-allylcysteine: Effect on Thyroid hormone and circulatory antioxidant system in experimental diabetic rats

Cited by 38 publications

References 35 publications

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway

Garcinia kolaseed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats

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