Ameliorative potential of vitamin P and digoxin in ischemic–reperfusion induced renal injury using the Langendorff apparatus

Muthuraman, Arunachalam; Kaur, Parneet; Kaur, P.; Singh, Harwinder; Boparai, Preetinder Singh

doi:10.1016/j.lfs.2014.12.022

Cited by 5 publications

(1 citation statement)

References 58 publications

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“…It is found in various fruits and vegetables. It is also known as rutoside, quercetin-3-Orutinoside, sophorin, and vitamin P [11,12]. The citrus flavonoid of rutin glycoside is a low molecular weight polyphenolic compound.…”

Section: Introductionmentioning

confidence: 99%

"Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions"

Muthuraman

2023

BJSTR

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Rutin is a bioflavonoid and plant pigment. It is found in various fruits and vegetables. Chemically, it is known as rutoside, quercetin-3-O-rutinoside, sophorin, and vitamin P. It has antioxidant, anti-inflammatory, and immunomodulation-associated neuroprotective and anti-Alzheimer actions. The role of rutin against glyphosate-induced cognitive dysfunction in adult zebrafish has not been studied yet. The present study focused on the role of rutin on glyphosate-induced cognitive dysfunction in adult zebrafish. The glyphosate (GYP, 0.5 mg/L), rutin (50, 100, and 150 µg/L), and donepezil (DP, 1 µg/mL) for 30 minutes/day were exposed for 14 consecutive days. On the 14th day, the neurobehavioural changes were assessed by three horizontal compartment test, optokinetic motor response (OMR), startle response (SR), and T-maze tests. On the 15th day, animals were sacrificed and brain biomarker changes i.e., brain acetylcholinesterase (AChE) activity, thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) levels were estimated. The exposure to rutin ameliorated the GYP-induced cognitive dysfunctions and changes in tissue biomarkers. The results are similar to DP-exposed animals. Hence, rutin can be useful for the treatment of herbicide toxicity like GYP-associated neurocognitive disorders viz anti-oxidant, anti-lipid peroxidation, and modulatory action of cholinergic neurotransmitter activities.

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Section: Introductionmentioning

confidence: 99%

"Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions"

Muthuraman

2023

BJSTR

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Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy

Wang

et al. 2020

Biomedicine & Pharmacotherapy

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Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice

Zhu¹,

Zhang²,

Zhang³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. Methods: IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced glutathione (GSH), total reactive oxygen species (ROS) level and superoxide dismutase (SOD) were examined. Doppler was used to investigate renal arterial resistance. The isolated renal arterial rings served for hypoxia/reoxygenation analysis. Acetylcholine (ACh) and sodium nitroprusside (SNP)-induced relaxations of isolated renal arterial rings were exerted. Results: Vitamin C supplementation preserved kidney morphology and renal function following IRI. It was shown that pretreatment with vitamin C for mice subjected to IRI significantly elevated renal NO and GSH levels after reperfusion. Meanwhile, vitamin C administration decreased resistance index of renal artery and ameliorated oxidative stress secondary to IRI. The total ROS level in renal artery was decreased whereas the renal arterial SOD expression was increased by vitamin C supplementation following IRI. Pretreatment with vitamin C significantly potentiated the ACh and SNP-induced relaxations in both control and hypoxic renal arterial rings. Conclusion: Vitamin C protects kidney function and renal arterial reactivity against IRI. The protective role of vitamin C is linked to ROS, SOD, GSH and NO levels in renal ischemic injury.

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Ameliorative potential of vitamin P and digoxin in ischemic–reperfusion induced renal injury using the Langendorff apparatus

Cited by 5 publications

References 58 publications

"Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions"

"Ameliorative Potential of Rutin on Glyphosate-induced Cognitive Dysfunction in Adult Zebrafish Model via Antioxidant and Acetylcholinesterase Inhibitory Actions"

Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy

Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice

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