Amelioratory Effect of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Function and Oxidative Stress Markers in Lead-intoxicated Rats

Onah, Christian Ejike; Meludu, SC; Dioka, CE; Onuegbu, Anaelechi J.; Onah, Chinwemma; Ajaghaku, Daniel Lotanna; Johnkennedy, Nnodim; Obi, Ejeatuluchukwu

doi:10.9734/ejmp/2016/23763

Cited by 9 publications

(18 citation statements)

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“…These natural antioxidant substances can illustrate the antioxidant property of MO against induced oxidative stress [79]. Moringa oleifera has been reported to exhibit efficient antioxidant and free-radical scavenging properties via lowering LPO levels in various tissues [32]. In this study, MO brought MDA levels to a normal level, and replenished the decreased level of GSH, SOD, and CAT, possibly due to its capability of scavenging the free radical generated after fluoride exposure.…”

Section: Discussionmentioning

confidence: 65%

“…This replenishing of GSH may be responsible for the regaining of GPx and GST activity. The antioxidant capacity of MO has already been reported in some investigations; Onah et al, [32] concluded that supplementation of MO extracts is associated with a significant improvement in the levels of both liver and kidney GST, SOD, and CAT during lead acetate intoxication in fish [33]. Similarly, Uma et al [34] and Fakurazi et al [35] showed that MO leaves protected against acetaminophen-induced liver damage by decreasing liver enzymes and hepatic lipid peroxidation as well as increasing antioxidant enzyme levels.…”

Section: Discussionmentioning

confidence: 74%

“…It is characterized by resistance to diseases, fast growth, and easy adaption to commercial diets [30]. Several studies were performed to evaluate the importance of medicinal plants' leaf extracts for detoxification of polluted ecosystems [31][32][33][34][35], promote fish growth [36], and improve resistance against toxicity. However, in one recent study which has evaluated the ameliorative effect of MO leaf extract against sodium fluoride (NaF) in sea bream via the estimation of liver function, catalase, and superoxide dismutase activity [37], the authors concluded an efficient hepatoprotective and antioxidant effect of MO leaf extract.…”

Section: Introductionmentioning

confidence: 99%

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Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Ahmed

Sadek

Soliman

et al. 2020

Animals

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The potential antioxidant property of Moringa oleifera (MO) has been the recent focus of an increased number of studies. However few studies investigated its antioxidative ability against sodium fluoride-induced redox balance breakdown in Oreochromis niloticus. Thus, this study evaluates the effects of MO against the oxidative stress induced by sub-chronic exposure to sodium fluoride (NaF). A total of 264 fish (40 ± 3 g BW) were used to calculate the 96 hr-LC50 of NaF and perform the sub-chronic exposure study. 96 hr-LC50 of NaF was calculated as (61 mg/L). The 1/10 dose of the calculated 96 hr-LC50 (6.1 mg/L) was used to complete the sub chronic exposure for eight weeks. Fish were divided into four groups (n = 51; three replicates each); control, non-treated group; NaF group (exposed to NaF 6.1 mg/L); MO group (treated with 1% MO of diet); and NaF+MO (exposed to NaF 6.1 mg/L and treated with 1% MO of diet). The results revealed that the sub-chronic exposure to NaF (6.1 mg/L) was substantially increased malondialdehyde (MDA) and decrease the activities of superoxide dismutase (SOD), catalase (CAT), glutathione reduced (GSH), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) in the gills, liver, kidney, and muscle tissue in a time-dependent manner. In addition, a significant reduction in mRNA expression of GST in the liver was reported following NaF exposure. On the contrary, dietary supplementation of MO to NaF-exposed fish resulted in a significant reduction in MDA levels, and a significant elevation of SOD, CAT, GSH, GPx, and TAC activities in a time-dependent manner, in addition to significant elevation of GST mRNA expression in liver tissue. It could be concluded that a 1% MO (w/w) ration is a promising antioxidant plant that may successfully use to interfere with the oxidation processes induced by NaF in various tissues of Oreochromis niloticus.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Ahmed

Sadek

Soliman

et al. 2020

Animals

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“…A marked decrease occurred in contents of antioxidant enzymes (GSH, GST, catalase, and GPx) and nitric oxide in the liver by DcNa. The MLE or silymarin treatment decreased in the effect of DcNa on liver enzymes and lipid peroxidation with increased hepatic antioxidant enzymes as well as a reduction in elevated nitric oxide (Onah et al, ).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant traits and protective impact ofMoringa oleiferaleaf extract against diclofenac sodium-induced liver toxicity in rats

El-Hadary

Ramadan

2018

J Food Biochem

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Moringa oleifera gained importance as a medicinal plant. The current study assesses Moringa leaf ethanol extracts (MLE) against experimentally diclofenac sodium (DcNa)‐induced liver toxicity in male rats. Leaves were extracted with different solvents differing in polarity. Assessment involved total phenolic compounds, total flavonoids and radical scavenging activity against 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH·). HPLC was performed for identifying phenolic compounds, wherein ethyl vanillin (1,205 mg/kg), 3‐OH‐tyrosol (812.2 mg/kg), benzoic acid (273.8 mg/kg), salicylic acid (240.0 mg/kg), chlorogenic acid (233.3 mg/kg) and 3,4,5‐methoxy‐cinnamic acid (172.5 mg/kg) were measured. Fifty animals (each treatment group consisted of 10 rats) were subjected to five treatments and the experiment lasted for 4 weeks. Animals were exposed to DcNa (100 mg/kg) and two doses of MLE as well as silymarin (an antioxidant flavonoid C25H22O10) for 4 weeks. Liver marker enzymes, including alkaline phosphatase, alanine transaminase, and aspartate transaminase as well as urea, uric acid, and creatinine were increased. Serum albumin and total protein decreased in DcNa‐treated rats. Homogenates nitric oxide increased in liver tissue of the DcNa‐treated rats, while the activity of each of glutathione peroxidase, glutathione‐S‐transferase, glutathione, and catalase decreased. It could be concluded that MLE in both doses and silymarin are considerably hepatoprotective with antioxidant activity (AOA) against DcNa‐induced hepatotoxicity in rats. Practical applications Administration of MLE caused improvements in kidney functions and acted as antioxidant enzymes as compared with silymarin (as a reference drug). AOA was exhibited by MLE in vivo, and this would have a positive effect against oxidative liver damage caused by DcNa. Plasma membrane was protected and the regenerative and reparative capacity of liver increased by phenolics in the MLE. The study demonstrated the MLE hepatoprotective activity and recommends using M. oleifera leaves for the treatment of liver disorders.

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“…Zinc and α-lipoic acid were reported to reduce the harmful effects of α-CP on the reproductive system of male rat [18]. To the best of our knowledge, there are no attempts of using the "Miracle Plant, Moringa oleifera L." against α-CP toxicity; however, the plant is known for its antioxidant properties [19][20][21][22][23]. For example, MO extracts were reported to ameliorate acetaminophen-induced hepatotoxicity in rats [21]; lead acetate-induced changes in liver and kidney function parameters and oxidative stress markers in rats [22]; diclofenacinduced hepatotoxicity in rats [24]; alcohol-induced hepatotoxicity…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Moringa Tea Against Cypermethrin-Induced Hepatorenal Dysfunction, Oxidative Stress, and Histopathological Alterations in Female Rats

Mansour

Mohamed

Ali

et al. 2018

Asian J Pharm Clin Res

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Objectives: Exposure to α-cypermethrin (α-CP) may yield reactive oxygen species (ROS) that is responsible for oxidative stress in mammals. A variety of antioxidants were used to alleviate α-CP-induced toxicity in experimental animals. To the best of our knowledge, there are no attempts of using Moringa oleifera L. (MO) plant extracts against α-CP-induced toxicity. Therefore, this study was conducted.Methods: A total of 16 adult female rats were segregated into equally four groups: One group administered α-CP orally at a dose of 0.05/mg kg bw/ day; and the second group was freely allowed to drink MO leaf extract (moringa tea [MOT]) + the α-CP dose. The other two groups represented negative and positive controls. The daily consumption of the solutions was estimated. At the end of experiments (28 day), all animals were subjected to the planned manifestations.Results: MOT has proved its palatability as drinking solution more than water. Compared with control results, the relative weights of liver and brain recorded significant increases, while that of kidney, heart, spleen, ovary, and lung decreased significantly. Furthermore, alterations in the architecture of the liver, kidney, and brain were observed. α-CP treatment induced high elevation of the levels of aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, creatinine, and malondialdehyde, while caused decline of butyrylcholinesterase, urea, superoxide dismutase, and total antioxidant capacity levels. Coadministration of MOT restored biochemical and histopathological alterations caused by α-CP to a great extent.Conclusion: The present study introduces novel data on the protective effect of MO leaf extract against CP toxicity and sheds light on the palatability of “MOT” to rodents.

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Amelioratory Effect of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Function and Oxidative Stress Markers in Lead-intoxicated Rats

Cited by 9 publications

References 0 publications

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Antioxidant traits and protective impact ofMoringa oleiferaleaf extract against diclofenac sodium-induced liver toxicity in rats

The Protective Effect of Moringa Tea Against Cypermethrin-Induced Hepatorenal Dysfunction, Oxidative Stress, and Histopathological Alterations in Female Rats

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