Ameloblastic Fibrosarcoma of the Jaws — Report of Three Cases

Chomette, G; Auriol, M; Guilbert, F; Delcourt, A.

doi:10.1016/s0344-0338(83)80083-1

Cited by 43 publications

(5 citation statements)

References 15 publications

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“…Of the four recurrent AFs presented here, two revealed unequivocal evidence of sarcomatous transformation of the previously benign mesenchymal tumor component. As reported by many other authors (17–19, 21, 22), the epithelial elements within the malignantly transformed tumors disappeared completely in both tumors, thus showing histologic features identical to a fibrosarcoma. It is interesting to note that one AF of the present series involving a 6‐year‐old boy did show further maturation with typical tubular dentin formation in its recurrent tumor.…”

Section: Discussionsupporting

confidence: 82%

“…Therefore, these findings do not support the concept of AF developing into AFO and eventually into complex odontomas. The neoplastic nature of AF is often suggested by the fact that some of these tumors could recur following surgery (12,(14)(15)(16) and that malignant transformation from a pre-existing AF has been occasionally reported (17)(18)(19)(20)(21)(22). Of the four recurrent AFs presented here, two revealed unequivocal evidence of sarcomatous transformation of the previously benign mesenchymal tumor Figure 7 Ameloblastic fibro-odontoma showing similar features of ameloblastic fibroma, but also containing dentin and enamel matrix (arrows).…”

Section: Discussionmentioning

confidence: 99%

“…The neoplastic nature of AF is often suggested by the fact that some of these tumors could recur following surgery (12, 14–16) and that malignant transformation from a pre‐existing AF has been occasionally reported (17–22). Of the four recurrent AFs presented here, two revealed unequivocal evidence of sarcomatous transformation of the previously benign mesenchymal tumor component.…”

Section: Discussionmentioning

confidence: 99%

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Ameloblastic fibroma and related lesions: a clinicopathologic study with reference to their nature and interrelationship

Chen

Gao

et al. 2005

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ameloblastic fibroma and related lesions: a clinicopathologic study with reference to their nature and interrelationship

Chen

Gao

et al. 2005

J Oral Pathology Medicine

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“…Adjuvant post-operative radiotherapy was used successfully in a case with a very extensive maxillary lesion by DeNittis et al (15). Due to the fact that only one of the reported cases have documented metastasis (21), routine neck dissection for AFS does not seem to be indicated.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature

Bregni

Taylor

García

2001

J Oral Pathology Medicine

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Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour. To date, 60 well-documented cases have been published in the English-language literature. Two additional cases located in the posterior region of the mandible are reported. The relevant clinicopathological features of these cases, as well as those previously reported are discussed. Approximately two-thirds of AFS are malignant tumors de novo, with an average age of the affected patients being 22.9 years. This age is lower than the one observed in AFS developing from a pre-existent benign lesion (mean 33 years). Although regional and distant metastases are very infrequent, AFS is a locally aggressive lesion, with 23 (37%) of the reported cases having at least one recurrence; 12 patients (19.3%) died of the disease. Wide surgical excision with long-term follow-up remains the treatment of choice for this neoplasm.

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“…Rezidive treten in knapp 40% der Fälle auf, Fernmetastasen sind jedoch selten. Von den bisher publizierten Fällen wurden bisher nur in 2 Fällen Metastasen in Lymphknoten, Lunge und anderen Organen dokumentiert [15,27].…”

Section: Ameloblastisches Fibrosarkomunclassified

Maligne odontogene Tumoren

Jundt

Reichart

2008

Pathologe

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Malignant odontogenic tumors are extremely rare. As with benign odontogenic tumors, malignant epithelial odontogenic tumors or odontogenic carcinomas are distinguished from the even rarer mesenchymal ones, the odontogenic sarcomas. The existence of odontogenic carcinosarcomas is not yet acknowledged by the World Health Organization. Odontogenic carcinomas comprise ameloblastic carcinoma (AmCa), primary intraosseous carcinoma (PIOC), clear cell odontogenic carcinoma, odontogenic ghost cell carcinoma (OGCC), and the special case of metastasizing ameloblastoma. Odontogenic sarcomas consist of ameloblastic fibrosarcoma and ameloblastic fibrodentinosarcoma and fibroodontosarcoma. Whereas metastasizing ameloblastoma can be diagnosed only after having metastasized, all other malignant odontogenic tumors present with atypia, increased cellularity and mitoses, and invasion. Odontogenic sarcomas are regarded as low-grade tumors that rarely metastasize. Odontogenic carcinomas, however, especially AmCa, OGCC, and PIOC, are more aggressive, with a 5-year survival rate of about 70% for AmCa and OGCC and a 3-year survival rate of about 37% for PIOC. Radical surgery, eventually in combination with radiotherapy, is the treatment of choice.

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Ameloblastic Fibrosarcoma of the Jaws — Report of Three Cases

Cited by 43 publications

References 15 publications

Ameloblastic fibroma and related lesions: a clinicopathologic study with reference to their nature and interrelationship

Ameloblastic fibroma and related lesions: a clinicopathologic study with reference to their nature and interrelationship

Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature

Maligne odontogene Tumoren

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