Ameloblastoma with distinctive granular cell pattern: An 8case study

Abstract

Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern.

Granular cell odontogenic tumor: report of a rare case and a review of literature

“…Histopathologically, in the GCOT, a background of granular cells is seen, in which strips, islets, or narrow cords of odontogenic epithelium are located. But in GCA, a background of islets or ameloblastoma follicles is seen and in their center, the stellar reticulum with a round nucleus and granular cytoplasm can be seen [ 19 ]. Granular cells of GCT have similarities to those of GCOT, but they show strong immunoreactivity for the S-100 protein in contrast to GCOT.…”