Amentoflavone Inhibits ERK-modulated Tumor Progression in Hepatocellular Carcinoma In Vitro

Lee, Kun Ching; Tsai, Jai Jen; Tseng, Chih‐Wei; Kuo, Yi Chun; Chuang, Yaochen; Lin, Song; Hsu, Fei‐Ting

doi:10.21873/invivo.11274

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…Increasing evidences demonstrate that AMF controls cell proliferation, apoptosis, invasion, metastasis, autophagy, transcription and drug-resistance in various types of cancers, such as lung cancer ( Banerjee et al, 2002a ; Banerjee et al, 2002b ; Jung et al, 2017 ; Hu et al, 2018 ; Park and Kim, 2019 ; Shen et al, 2019 ; Kim et al, 2020 ; Chen et al, 2021 ), cervical cancer ( Lee et al, 2011 ), ovarian cancer ( Liu et al, 2017a ; Zhang et al, 2020 ), bladder cancer ( Chiang et al, 2019 ), osteosarcoma ( Pan et al, 2017 ; Lee et al, 2019 ), melanoma ( Guruvayoorappan and Kuttan, 2007 ; 2008b ; a ; Siveen and Kuttan, 2011 ), breast cancer ( Lee et al, 2009 ; Pei et al, 2012 ; Lee et al, 2013 ; Chen et al, 2015 ; Aliyev et al, 2021 ), liver cancer ( Zheng et al, 2016 ; Chen et al, 2017a ; Lee et al, 2018a ; Lee et al, 2018b ; Tsai et al, 2018 ), brain cancer ( Yen et al, 2018 ; Zhaohui et al, 2018 ; Hsu et al, 2019 ; Chen et al, 2020c ), and oral squamous cell carcinoma ( Chen et al, 2020b ) via regulating kinds of signaling pathways ( Figure 2 ). These studies provide a lot of evidences that AMF is a potential effective multi-targeting drug for the prevention and treatment of a variety of cancers.…”

Section: The Multifunctional Biological Activities Of Amentoflavonementioning

confidence: 99%

“…As a heterodimeric transcription factor, NF-κB is composed of p50 and p65 subunits, mediates tumor invasion and metastasis through regulating the expressions of metastasis-associated proteins such as XIAP, MMP-2, MMP-9, cyclinD1, and VEGF ( Rasmi et al, 2020 ). In vitro studies, AMF suppresses cell viability, invasion and migration of different types of cancers, including glioblastoma ( Hsu et al, 2019 ) and HCC ( Lee et al, 2018b ) through inhibiting NF-κB activation and NF-κB-mediated downstream gene expression. Similarly, AMF reduces the invasion ability of NSCLC cells through blocking NF-κB signaling pathway and NF-κB p65 nuclear translocation ( Chen et al, 2021 ).…”

Section: The Multifunctional Biological Activities Of Amentoflavonementioning

confidence: 99%

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Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Xiong

Tang²,

Lai³

et al. 2021

Front. Pharmacol.

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Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over 40 years. Amentoflavone has been extensively recorded as a molecule which displays multifunctional biological activities. Especially, amentoflavone involves in anti-cancer activity by mediating various signaling pathways such as extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and emerges anti-SARS-CoV-2 effect via binding towards the main protease (Mpro/3CLpro), spike protein receptor binding domain (RBD) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Therefore, amentoflavone is considered to be a promising therapeutic agent for clinical research. Considering the multifunction of amentoflavone, the current review comprehensively discuss the chemistry, the progress in its diverse biological activities, including anti-inflammatory, anti-oxidation, anti-microorganism, metabolism regulation, neuroprotection, radioprotection, musculoskeletal protection and antidepressant, specially the fascinating role against various types of cancers. In addition, the bioavailability and drug delivery of amentoflavone, the molecular mechanisms underlying the activities of amentoflavone, the molecular docking simulation of amentoflavone through in silico approach and anti-SARS-CoV-2 effect of amentoflavone are discussed.

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Section: The Multifunctional Biological Activities Of Amentoflavonementioning

confidence: 99%

Section: The Multifunctional Biological Activities Of Amentoflavonementioning

confidence: 99%

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Xiong

Tang²,

Lai³

et al. 2021

Front. Pharmacol.

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show abstract

“…The 10% FBS/RPMI medium were placed into the lower chamber of cell migration/invasion inserts. Cells were allowed for migration or invasion for 48 h, then cells were be fixed with 4% paraformaldehyde in PBS for 30 min at 4˚C, stained with crystal violet solution for 15 min and photographed by microscope (Nikon ECLIPSE Ti-U, Minato City, Tokyo, Japan), and quantified by ImageJ software version 1.50 (National Institutes of Health, Bethesda, MD, USA) (18,19).…”

Section: Methodsmentioning

confidence: 99%

Induction of Apoptosis and Inhibition of EGFR/NF-κB Signaling Are Associated With Regorafenib-sensitized Non-small Cell Lung Cancer to Cisplatin

Chiou

Hsu

et al. 2021

In Vivo

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Background/Aim: The combination of regorafenib with cisplatin/pemetrexed has indicated controllable safety and encouraging antitumor activity in non-small cell lung cancer (NSCLC) patients. However, the anti-NSCLC effects and action mechanisms of regorafenib combined with cisplatin is ambiguous. The major goal of the study was to study the inhibitory effects and action mechanisms of regorafenib combined with cisplatin in NSCLC cells. Materials and Methods: Cell viability, flow cytometry, immunofluorescence staining, western blotting, migration, and invasion assays were employed to verify the anti-NSCLC effects and mechanisms of regorafenib in combination with cisplatin. Results: Cisplatin-induced epidermal growth factor receptor (EGFR)/nuclear factor ĸB (NF-ĸB) signaling was effectively inhibited by regorafenib treatment. Regorafenib, erlotinib (EGFR inhibitor) and QNZ (NF-ĸB inhibitor) may all enhance the cytotoxicity effect of cisplatin. The invasion ability was effectively decreased by combination treatment. Caspase-dependent and -independent apoptosis was activated by cisplatin combined with regorafenib. Conclusion: Apoptosis induction and EGFR/NF-ĸB inactivation correlate with regorafenib-enhanced anti-NSCLC efficacy of cisplatin.This study provides evidence of the therapeutic efficacy of regorafenib in combination with cisplatin on NSCLC.Cisplatin, a platinum-based anticancer drug, is standard treatment for advanced non-small cell lung cancer (NSCLC). DNA damage-induced apoptosis correlates with the anticancer mechanism of cisplatin (1, 2). Cell and animal models have revealed that enhancement of apoptosis induction and suppression of oncogenic signaling such as Wnt, AKT, epidermal growth factor receptor (EGFR), and nuclear factor-kappaB (NF-ĸB) by potential complementary approaches have been reported to sensitize NSCLC cells to cisplatin (3-6). For instance, sodium valproate, a histone deacetylase inhibitor, and microRNA miR-381 have been found to enhance anti-NSCLC efficacy of cisplatin through inducing apoptosis and inhibiting NF-ĸB signaling, respectively (7, 8).Several tyrosine kinase inhibitors (TKIs) targeting EGFR and anaplastic lymphoma kinase (ALK) have been shown to improve survival of NSCLC patients receiving platinum-based doublet chemotherapy (9, 10). Regorafenib, an oral multitarget TKI, is used for the treatment of solid tumors such as hepatocellular carcinoma (HCC), renal cell carcinoma, differentiated thyroid cancer, and metastatic colorectal cancer (11,12). Induction of apoptosis and down-regulation of AKT/NF-ĸB signaling were associated with regorafenibinhibited progression of NSCLC cells (13). In addition, the combination of regorafenib with cisplatin/pemetrexed has shown manageable tolerability and encouraging antitumor 2569 This article is freely accessible online.

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“…Lee et al found that AME inhibited fatty acid synthesis, increased caspase-3 activity and promoted DNA breakage, thereby accelerating apoptosis of breast cancer cell SKBR3 and inhibiting cell proliferation in a dose-dependent manner to exert antitumor effects [18] . ROB was able to reduce the production of NO, the pro-inflammatory cytokine interleukin-1β (IL-1) and interleukin-6 production in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) [19] .…”

Section: Introductionmentioning

confidence: 99%

Total biflavonoids extraction from Selaginella chaetoloma utilizing ultrasound-assisted deep eutectic solvent: Optimization of conditions, extraction mechanism, and biological activity in vitro

Liu,

Qiao,

Gao

et al. 2023

Ultrasonics Sonochemistry

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Amentoflavone Inhibits ERK-modulated Tumor Progression in Hepatocellular Carcinoma In Vitro

Abstract: Abstract. Background

Cited by 11 publications

References 15 publications

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Induction of Apoptosis and Inhibition of EGFR/NF-κB Signaling Are Associated With Regorafenib-sensitized Non-small Cell Lung Cancer to Cisplatin

Total biflavonoids extraction from Selaginella chaetoloma utilizing ultrasound-assisted deep eutectic solvent: Optimization of conditions, extraction mechanism, and biological activity in vitro

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