American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for The Evaluation and Treatment of Male Sexual Dysfunction: a Couple’s Problem–2003 Update

Guay, André T.; Spark, Richard F.; Bansal, Shikha; Cunningham, Glenn R.; Goodman, Neil F.; Nankin, Howard R.; Petak, Steven M.; Perez, Jesús B.

doi:10.4158/ep.9.1.77

Cited by 84 publications

(15 citation statements)

References 87 publications

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“…In the US, the prevalence of erectile dysfunction (ED) in men aged ≥20 years is 18.4% suggesting that more than 18 million are affected [ 1 , 2 ]. Among older men, these numbers significantly increase affecting their overall quality of life [ 3 ]: at age 40, approximately 44% are affected and this number increases nearly to 70% by age of 70 [ 2 , 4 ]. The economic burden of ED is unclear, yet studies have shown that the cost of treatment could reach $15 billion if all men seek treatment [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004

López

Wang²,

Tsilidis

et al. 2015

PLoS ONE

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ObjectivesCaffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies. We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED.Material and MethodData were analyzed for 3724 men (≥20 years old) who participated in the National Health and Nutrition Examination Survey (NHANES). ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable logistic regression analyses using appropriate sampling weights were conducted.ResultsWe found that men in the 3rd (85-170 mg/day) and 4th (171-303 mg/day) quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day) [OR: 0.58; 95% CI, 0.37–0.89; and OR: 0.61; 95% CI, 0.38–0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01).ConclusionCaffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.

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Section: Introductionmentioning

confidence: 99%

Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004

López

Wang²,

Tsilidis

et al. 2015

PLoS ONE

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“…It is known that PDE 5 inhibitors are considered first line therapy for ED. 8-10 A comparative network meta-analysis of the PDE 5 inhibitors concluded tadalafil may be the most effective PDE 5 inhibitor for ED followed by vardenafil. 35 These results were based on the the primary endpoints of the GAQ-1 and change from baseline to study end on the IIEF-EF domain score.…”

Section: Discussionmentioning

confidence: 99%

“…Because of efficacy, ease of use, and a favorable adverse effect profile, the American Urology Association along with other national organizations recommend PDE 5 inhibitors as first-line agents in the treatment of ED. 8-10 Four PDE 5 inhibitors are currently on the market: sildenafil, vardenafil, tadalafil, and avanafil. The newest phosphodiesterase inhibitor, avanafil (Stendra) manufactured by Vivus, Inc, was approved in April 2012 by the US Food and Drug Administration for the treatment of ED.…”

Section: Introductionmentioning

confidence: 99%

Avanafil for Erectile Dysfunction

2013

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“…ED is also associated with some therapeutic agents like antihypertensives, antipsychotics, antidepressants, and drugs for diabetes mellitus. [101112]…”

Section: Causes Of Impotencementioning

confidence: 99%

Exploring scientifically proven herbal aphrodisiacs

Kotta¹,

Ansari²,

Ali³

2013

Phcog Rev

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Procreation was an important moral and religious issue and aphrodisiacs were sought to ensure both male and female potency. Sexual dysfunction is an inability to achieve a normal sexual intercourse, including premature ejaculation, retrograded, retarded or inhibited ejaculation, erectile dysfunction, arousal difficulties (reduced libido), compulsive sexual behavior, orgasmic disorder, and failure of detumescence. The introduction of the first pharmacologically approved remedy for impotence, Viagra (sildenafil) in 1990s caused a wave of public attention, propelled in part by heavy advertising. The search for such substances dates back millennia. An aphrodisiac is an agent (food or drug) that arouses sexual desire. The hunt for natural supplement from medicinal plants is being intensified mainly because of its fewer side effects. In this review, we have mentioned the pharmacologically tested (either in man or animal or in both) aphrodisiac plants, which have claimed for its uses.

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American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for The Evaluation and Treatment of Male Sexual Dysfunction: a Couple’s Problem–2003 Update

Cited by 84 publications

References 87 publications

Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004

Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004

Avanafil for Erectile Dysfunction

Exploring scientifically proven herbal aphrodisiacs

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