American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography

Saslow, Debbie; Boetes, C.; Burke, Wylie; Harms, Steven E.; Leach, Martin O.; Lehman, Constance D.; Morris, Elizabeth A.; Pisano, Etta D.; Schnall, Mitchell D.; Sener, Stephen F.; Smith, Robert A.; Warner, Ellen; Yaffe, Martin J.; Andrews, Kimberly S.; Russell, Christy

doi:10.3322/canjclin.57.2.75

Cited by 2,294 publications

(965 citation statements)

References 80 publications

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“…Yearly screening with mri is now recommended in the United States for women with >20% to 25% lifetime risk of breast cancer 40 . In Canada, the most recent recommendations on this topic were published in 2007 by the National Hereditary Cancer Task Force 41 , whose panel recommended annual mg, complemented by mri where available, and added that whenever possible, imaging should be delivered by an experienced team of radiologists with expertise in mri, mg, and us.…”

Section: Discussionmentioning

confidence: 99%

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Multimodality Breast Cancer Screening in Women with a Familial or Genetic Predisposition

et al. 2010

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BackgroundWomen with a predisposition for breast cancer require a tailored screening program for early cancer detection. We evaluated the performance of mammography (mg), ultrasonography (us), and magnetic resonance imaging (mri) screening in these women. Patients and MethodsIn asymptomatic women either confirmed as BRCA1/2 carriers, or having a greater than 30% probability of being so as estimated by brcapro [Berry D, Parmigiani G. Duke spore (Specialized Program of Research Excellence) in Breast Cancer. 1999], we conducted a prospective comparative trial consisting of annual mri and mg, and biannual us and clinical breast examination. All evaluations were done within 30 days of one another. For each screening round, imaging tests were independently interpreted by three radiologists. ResultsThe study enrolled 184 women, and 387 screening rounds were performed, detecting 12 cancers (9 infiltrating, 3 in situ), for an overall cancer yield of 6.5%. At diagnosis, 7 infiltrating cancers were smaller than 2 cm (T1); only 1 woman presented with axillary nodal metastases. All tumours were negative for the human epidermal growth factor receptor 2. Of the 12 cancers, mri detected 10, and mg, 7; us did not identify any additional cancers. The overall recall rate after mri was 21.8%, as compared with 11.4% for us and 16.1% for mg. Recall rates declined with successive screening rounds. In total, 45 biopsies were performed: 21 as a result of an us abnormality; 17, because of an mri lesion; and 7, because of a mg anomaly. InterpretationIn high-risk women, mri offers the best sensitivity for breast cancer screening. The combination of yearly mri and mg reached a negative predictive value of 100%. The recall rate is greatest with mri, but declines for all modalities with successive screening rounds.

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Section: Discussionmentioning

confidence: 99%

“…Our trial was terminated early, after publication of guidelines from the American Cancer Society recommending screening mri as an adjunct to mg in high-risk women 40 .…”

Section: Discussionmentioning

confidence: 99%

Multimodality Breast Cancer Screening in Women with a Familial or Genetic Predisposition

et al. 2010

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“…3 Ultrasound imaging has higher sensitivity than mammography in imaging dense breast but with low specificity in screening breast cancers. 4,5 Magnetic resonance imaging (MRI) was reported to have results correlated better with pathology findings than mammography and obtained promising results when dynamic contrast agents are applied. [6][7][8] However, MRI is expensive and exogenous agents are needed for better contrast.…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

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Abstract. Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as hemoglobin, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer imaging. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at the wavelength of 650 nm and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements and width of measurement patch, have been investigated. Our results indicate that an air-cooling EMCCD camera is good enough for the transmission mode DOT imaging. We have also found that measurements at six angular projections are sufficient for DOT to reconstruct the optical targets with 2 and 4 times absorption contrast when the CT guidance is applied. Finally, we have described our future research plan on integration of a multispectral DOT imaging system into a breast CT scanner.

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“…From the results of mammography 59% of the whole sample have a positive result, while MRI results say that only 15.2% of the sample have a positive result and after biopsy has performed the actual positive result is 13.3%. In a previous study [17], it was reported that MRI has high sensitivity ranging from 71% to 100% versus 16% to 40% for mammography in a high risk population. Screening mammograms alone, or screening breast ultrasounds alone, each found only a little more than half of the cancers.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging for Screening of Woman at High-Risk of Breast Cancer

Garout¹,

Ahmed²,

Jastaniah³

et al. 2014

ABCR

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MRI is an excellent option for detection of breast cancer for some selected groups, including those patients with a high probability to hit the disease. However, the high costs and low availability of the device have led to a decline in the application of imaging MRI. The aim of this study was to review usefulness of MRI as a new complementary way to detect breast cancer in routine annual checkup for women breasts of certain ages and breast mass. A cross-sectional Descriptive MRI study was performed on 105 asymptomatic women with a mean age of 49 years. The study group with at least one risk factor of breast cancer were presenting for routine annual screening or follow up at King Abdulaziz University Hospital in Jeddah. It has been found that, 48 patients had biopsy, they were recommended by magnetic resonance imaging and only 14 had positive results, while magnetic resonance imaging suggested 16 and mammography had 62 positive results. Magnetic resonance imaging is not recommended for the average-risk or the general population either; it had been advised for screening the high-risk women of breast cancer. Sensitivity of magnetic resonance imaging has been found to be much higher than of mammography but specificity was generally lower. We propose that it is reasonable to consider MRI as a complement to mammography in screening patients who were at high risk for breast cancer because Magnetic Resonance Imaging can detect small foci that are occult in mammography but we don't advise to check with the general population.

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American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography

Cited by 2,294 publications

References 80 publications

Multimodality Breast Cancer Screening in Women with a Familial or Genetic Predisposition

Multimodality Breast Cancer Screening in Women with a Familial or Genetic Predisposition

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Magnetic Resonance Imaging for Screening of Woman at High-Risk of Breast Cancer

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