American ginseng leaf: ginsenoside analysis and hypoglycemic activity

Xie, Jing‐Tian; Mehendale, Sangeeta R.; Wang, Anbao; Han, Aung H.; Wu, Jingsong; Osinski, Joachim; Yuan, Chun‐Su

doi:10.1016/j.phrs.2003.07.015

Cited by 108 publications

(82 citation statements)

References 17 publications

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“…This is consistent to the previous reports [21,22]. Although the active principles of ginseng are still not identified, it was totally named as ginsenoside while the subtypes of Rb1, Rb2, Rc, Rd, Re, and Rg were documented as the major [23]. However, there is no doubt that ginseng has the ability to improve insulin resistance after the intake of 150 mg/kg both our result [12] and others [21].…”

Section: Merit Of Ginseng In the Improvement Of Insulin Resistancesupporting

confidence: 92%

Merit of Ginseng in the Improvement of Insulin Resistance

Cheng

2010

Journal of Ginseng Research

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In the present review, the merit of ginseng in the improvement of insulin resistance has been introduced. Using the results in previous studies, we found that ginseng or ginsenoside Rh2 has the ability to reduce glucose-insulin index in rats with insulin resistance. Insulin resistance was induced by feeding of fructose-rich chow in rats. Insulin resistance was characterized by regular methods. Effectiveness of ginseng powder or extract Rh2 was identified in this animal model. Also, the application of ginseng for handling of diabetic disorders in China has been discussed. According to Chinese traditional medicine, ginseng is merit in the treatment of diabetic disorders named as Shiaw-Ker in Chinese. Therefore, it is no doubt that ginseng is helpful in the control of diabetic disorders either prevention or the treatment. Otherwise, the potential effect of ginseng on nervous functions shall be investigated in the future.

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Section: Merit Of Ginseng In the Improvement Of Insulin Resistancesupporting

confidence: 92%

Merit of Ginseng in the Improvement of Insulin Resistance

Cheng

2010

Journal of Ginseng Research

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“…Traditionally, ginseng leaf has been consumed mostly in the form of tea. Ginseng leaf is rich in polysaccharides, polyphenols, and flavonoids [8][9][10], and contents of some ginsenosides are higher than in the roots [11]. However, these compounds are tightly linked with carbohydrates such cellulose, pectin, or β-glucan.…”

Section: Discussionmentioning

confidence: 99%

“…Yet, it is possible to harvest ginseng leaves every year unlike ginseng roots. In addition, groups of scientists have found that ginseng leaves are rich in polysaccharides, polyphenol, flavonoids, and ginsenosides [8][9][10]. Shi et al [11] reported that the content of ginsenoside Re in P. ginseng leaves and roothairs is about five times higher than that of Rg1, but Re content is lower than that of Rg1 in the root.…”

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confidence: 99%

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Lee¹,

Lee²,

Cho³

et al. 2010

Journal of Ginseng Research

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“…Blood glucose levels As in our previous studies [22,23,27] , fasting blood glucose levels (measured by Glucose Analyzer, Hemocue, Angelholm, Sweden) and bodyweight were measured after fasting the animals for 4 h (starting from 09:00) on d 0 (before treatment), d 5, and d 12. Blood glucose levels were determined from tail vein blood samples at 13:00 using the Glucose Analyzer.…”

Section: Methodsmentioning

confidence: 99%

“…As shown in Figure 2, diabetic ob/ob mice had remarkably high baseline fasting blood glucose levels (>200 mg/dL), which decreased significantly after administration of high-dose of TGCG. For example, on d 5 blood glucose levels were 179.0±12.7 mg/dL [22][23][24][25][26][27][28] .…”

Section: Hplc Assaymentioning

confidence: 99%

Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng

Xie

Wang

et al. 2005

Acta Pharmacologica Sinica

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Aim: The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice. Methods: Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg) or oral administration (150 and 300 mg/kg) for 12 d. Fasting blood glucose levels and body weight were measured after fasting the animals for 4 h. Peripheral glucose use was also measured using an intraperitoneal glucose tolerance test. Results: In the injection group, a high dose of TGCG (200 mg/kg) significantly lowered the fasting blood glucose levels in ob/ob mice on d 12 (153 ± 16 mg/dL vs 203±9.8 mg/dL, P<0.01, compared to vehicle‐treated group). In the oral group, blood glucose decreased notably with a dose of TGCG (300 mg/kg) on d 12 (169.1±12.6 mg/dL vs211.6±13.8 mg/dL, P<0.05, compared to the vehicle‐treated group). Glucose tolerance was also improved markedly in ob/ob mice. Furthermore, a significant reduction in bodyweight (P<0.05) was observed after 12 d of TGCG (300 mg/kg) treatment in mice from the oral group. Conclusion: The results indicated that in a diabetic ob/ob mouse model TGCG was endowed with significant anti‐hyperglycemic and anti‐obesity properties. Therefore, the total ginsenosides extracted from Chinese ginseng leaves and the stem may have some potential for treating diabetes.

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American ginseng leaf: ginsenoside analysis and hypoglycemic activity

Cited by 108 publications

References 17 publications

Merit of Ginseng in the Improvement of Insulin Resistance

Merit of Ginseng in the Improvement of Insulin Resistance

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng

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