American Heart Association Atrial Fibrillation Research Summit

Estes, N.A. Mark; Sacco, Ralph L.; Al‐Khatib, Sana M.; Ellinor, Patrick T.; Bezanson, Judy L.; Alonso, Álvaro; Antzelevitch, Charles; Brockman, Randall; Chen, Peng Sheng; Chugh, Sumeet S.; Curtis, Anne B.; DiMarco, John P.; Ellenbogen, Kenneth A.; Epstein, Andrew E.; Ezekowitz, Michael D.; Fayad, Pierre; Gage, Brian F.; Go, Alan S.; Hlatky, Mark A.; Hylek, Elaine M.; Jerosch‐Herold, Michael; Konstam, Marvin A.; Lee, Richard; Packer, Douglas L.; Po, Sunny S.; Prystowsky, Eric N.; Redline, Susan; Rosenberg, Yves; Wagoner, David R. Van; Wood, Kathryn A.; Yue, Lixia; Benjamin, Emelia J.

doi:10.1161/cir.0b013e318224b037

Cited by 34 publications

(24 citation statements)

References 61 publications

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“…Given this expanding burden and the challenges in developing effective management strategies for AF and its complications, workshops of the American Heart Association and the National Heart, Lung, and Blood Institute have emphasized in recent years the importance of AF prevention, which largely relies on the recognition of the risk factors for its development. 11,12 Imaging variables may contribute significantly in this regard.…”

mentioning

confidence: 99%

Atrial Fibrillation Pathophysiology and Prognosis

Siontis

Gersh

2015

Circ: Cardiovascular Imaging

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confidence: 99%

Atrial Fibrillation Pathophysiology and Prognosis

Siontis

Gersh

2015

Circ: Cardiovascular Imaging

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“…Detection of the underlying AF disorder even clinically 'masked' could result in implementing effective treatment and improving prognosis [6,8,14]. Suggestion resulted in reducing aggressive approach to AF patients.…”

Section: Discussionmentioning

confidence: 99%

Aggressive approach and outcome in patients presenting atrial fibrillation and hypertension

Conti

Canuti

Mariannini

et al. 2013

International Journal of Cardiology

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Aim: Aggressive approach in patients presenting atrial fibrillation (AF) and hypertension could result in improving rhythm control and reducing admission. Methods: Out of 3475 patients presenting AF, those with hypertension (n = 1739, 52%) underwent standard (n = 591, group 1, years [2004][2005] or aggressive pharmacological and electrical approach (n = 1148, group 2, years 2006-2009). Overall, in 1071 patients AF duration was less than 48 h. Primary endpoint was rhythm conversion; secondary endpoints were modalities of rhythm conversion and reduction of admissions. Results: At univariate and multivariate analyses, AF lasting less than 48 h, absence of comorbidities and younger age were independent predictors of sinus rhythm; conversely, lack of sinus rhythm, older age, AF lasting more than 48 h and comorbidities were independent predictors of hospitalization. Overall, 55% of patients achieved sinus rhythm in group 1 versus 62% in group 2 (p=0.018). Interestingly, in patients with AF lasting less than 48 h, 89% achieved sinus rhythm, more likely by class 1C than by class III antiarrhythmic drugs (pb 0.001). Overall reduction of admission accounts for 60%; 50% of patients need admission in group 1 versus 29% in group 2 (pb 0.001). Conclusions: Aggressive pharmacological and electrical approach in patients presenting AF and hypertension significantly improved rhythm conversion overall up to 62%. Patients with AF lasting less than 48 h eventually achieved sinus rhythm up to 89%, mostly by class IC antiarrhythmic drugs. Admissions eventually reduced up to 60%.

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“…[29][30][31][32][33] Atrial-specific ion channels and atrial fibrosis are promising pharmacological targets for AF prevention and treatment, but clinical trials are lacking. 8 Risk stratification as achieved by Russo et al 18 using sensitive indices that detect subclinical disease will facilitate the development of robust risk prediction models and enable more personalized and targeted AF risk reduction. 34 However, data from large ethnically diverse populations are needed to confirm the incremental predictive ability of chamber-specific deformational indices.…”

Section: Hoitmentioning

confidence: 99%

“…15 A variety of novel risk factors for AF have been studied, notably atrial remodeling, which itself is associated with numerous factors (demographic, anthropomorphic, behavioral, classical cardiovascular risk factors, pulmonary disease, and hyperthyroidism) that interact with AF in a complex fashion. 8 Other novel risk factors include the biomarkers brain natriuretic peptide, C-reactive protein, and long-chain n-3 polyunsaturated fatty acids; and subclinical factors, such as pericardial fat, systolic blood pressure within the normal range, left ventricular (LV) diastolic function, and subclinical coronary artery disease. 16 However, it is unclear whether these novel risk factors improve risk prediction models, such as the community-based Framingham Risk Score.…”

mentioning

confidence: 99%

Refining the Risk for Atrial Fibrillation

Hoit

2015

Circ: Cardiovascular Imaging

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American Heart Association Atrial Fibrillation Research Summit

Cited by 34 publications

References 61 publications

Atrial Fibrillation Pathophysiology and Prognosis

Atrial Fibrillation Pathophysiology and Prognosis

Aggressive approach and outcome in patients presenting atrial fibrillation and hypertension

Refining the Risk for Atrial Fibrillation

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