Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua

Xia, Min; Yang, Jun; Zhang, Pan-Hua; Li, Xiaonian; Luo, Jifeng; Chen, Long; Wang, Yue‐Hu

doi:10.1007/s13659-018-0180-z

Cited by 11 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Piper yunnanense is traditionally used in China for removing blood stasis [214], promoting blood circulation and thought to be useful in antiplatelet therapies and in the treatment of thrombotic diseases [121].…”

Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

“…As a folk medicine in China, the whole plants of Piper mullesua are used to remove blood stasis, treat bleeding, bone fractures, injuries from falls, rheumatoid arthritis, rheumatic arthralgia, acroanesthesia, asthma, colds, stomach aches, abdominal pain, toothaches, swelling and pain of furuncles, dysmenorrhea, menoxenia, empyrosis, and snake and insect bites [214]. In addition, Manandhar [215] reported that the boiled juice of P. mullesua fruits is used in India folk medicine to treat coughs and colds.…”

Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

See 1 more Smart Citation

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

View full text Add to dashboard Cite

Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

show abstract

Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Four "naphthalene-devoid" tetra-and dihydroisoquinolines, named ealaines A−D (18−21), were isolated from the Congolese plant Ancistrocladus ealaensis. 32 Akihisa et al 33 isolated noroxyhydrastinine Corydalis tomentella [28] 402 Oleracein E Portulaca oleracea [31] 403 Pipermullesine B Piper mullesua [108] 404 Pipermullesine C Piper mullesua [108] 405 Delavatine A Incarvillea delavayi [109] 406 Neotatarine Acorus calamus [110] Cryptocarya griffithiana, and Dehaasia longipedicellata, over the past 5 years. [34][35][36][37][38][39] (+)-N-Methylisococlaurine (24) also was found in Cryptocarya species and (−)-N-methylcoclaurine (25) was identified in the rhizomes of Sinomenium acutum in 2014.…”

Section: 4′-oo-didemethylancistrocladinium a (A/b)mentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

147

View full text Add to dashboard Cite

Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

show abstract

“…The inhibitory effects of the compounds against rabbit platelet aggregation induced by thrombin (1 U/mL), PAF (0.4 μg/mL), AA (0.5 mM), or collagen (4 μg/mL) were evaluated according to published methods [ 28 – 30 ].…”

Section: Methodsmentioning

confidence: 99%

Chemical Constituents from the Whole Plant of Cuscuta reflexa

Aung

Xia

Hein

et al. 2020

Nat. Prod. Bioprospect.

Self Cite

View full text Add to dashboard Cite

Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4–15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. Graphic Abstract

show abstract

Amides, Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua

Cited by 11 publications

References 47 publications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Biologically active isoquinoline alkaloids covering 2014–2018

Chemical Constituents from the Whole Plant of Cuscuta reflexa

Contact Info

Product

Resources

About