Amidine-Based Compounds Affecting l-Arginine Metabolism

Maccallini, Cristina; Fantacuzzi, Marialuigia; Amoroso, Rosa

doi:10.1007/978-3-319-26009-9_4

L-Arginine in Clinical Nutrition 2016

DOI: 10.1007/978-3-319-26009-9_4

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Amidine-Based Compounds Affecting l-Arginine Metabolism

Cristina Maccallini

Marialuigia Fantacuzzi

Rosa Amoroso

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2022

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The N-(2,4-diarylthiazol-5-yl)benzamidines library creation and the effect of this compounds on cancer cell growth

Severin,

Kachaeva,

Pilyo

et al. 2022

Ukr. Bioorg. Acta

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A versatile and efficient protocol for the synthesis of library of N-(2,4-diarylthiazol-5-yl)benzamidines is described. We obtained a library of 25 diversity with different of substituents in four positions in key framework. The synthesized amidine derivatives were evaluated for their in vitro anticancer activity. Analysis of anticancer activity on 60 cancer cell lines showed a decrease of proliferation of Colon Cancer and Leukemia cell lines by more than half and allowed to establish the structure-activity relationship

show abstract

The N-(2,4-diarylthiazol-5-yl)benzamidines library creation and the effect of this compounds on cancer cell growth

Severin,

Kachaeva,

Pilyo

et al. 2022

Ukr. Bioorg. Acta

View full text Add to dashboard Cite

show abstract

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Amidine-Based Compounds Affecting l-Arginine Metabolism

Cited by 1 publication

References 38 publications

The N-(2,4-diarylthiazol-5-yl)benzamidines library creation and the effect of this compounds on cancer cell growth

The N-(2,4-diarylthiazol-5-yl)benzamidines library creation and the effect of this compounds on cancer cell growth

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