Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement

Abstract

In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100-200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur). The bioavailability of MSN-A-Cur and MSM-A-Cur was considerably higher than that of 'free curcumin'. These results indicate promising features of amine functionalized MSN as a carrier to deliver low solubility drugs with improved bioavailability via the oral route.

Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats

“…Curcuma longa L. dry extract was purchased from and certified by Java Plants (Solo, Indonesia). C-MSN was prepared according to the method described by Hartono et al (2016). Materials for C-MSN hepatoprotective study are carbon tetrachloride (E-Merck, Germany), corn oil (PT.…”

“…Ethanol was evaporated slowly under vacuum at a temperature of 55°C. Finally, curcumin loaded MSN was obtained (Hartono et al, 2016).…”

“…In our previous research curcumin has been loaded into mesoporous silica nanoparticles (C-MSN). It has been proven that C-MSN has a higher bioavailability than 'free curcumin' (Hartono et al, 2016) so that it was expected to have a better hepatoprotection activity. In the present study, the C-MSN hepatoprotective effect will be evaluated against curcumin.…”

Mesoporous silica nanorods for improved oral drug absorption

“…Mesoporous silica nanoparticles (MSNs), exhibiting attractive properties, such as large surface area [1], easy surface modification [2,3] and multiple morphology [4], have attracted extensive attention for their application in oral drug delivery [5,6]. Recently, numerous studies have synthesized MSNs with various properties [7,8], and they demonstrated that the physical parameters of mesoporous silica materials have played an important role in both in vitro and in vivo biological performance [9][10][11][12][13].…”

A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study

“…Enzyme immobilization in an inorganic support, such as mesoporous silica particles (MSP), is a convenient strategy due to its low cost, high surface area, tunable particle and pore size. Moreover, the potential of MSP as oral delivery systems was previously shown for small molecules, whose release could be triggered by external stimuli (e.g., the increase in pH along the GI-tract) [17][18][19] .…”