Amine-terminated dendritic polymers as promising nanoplatform for diagnostic and therapeutic agents’ modification: A review

Chromatographic Separation of Aromatic Amine Isomers: A Solved Issue by a New Amphiphilic Pillar[6]arene Stationary Phase

“…The new amphiphilic P6A-C10-2NH 2 stationary phase allows us to solve all of these challenging issues, ensuring an efficient separation of the isomers of haloanilines and toluidines. In addition, the separation performances of P6A-C10-2NH 2 toward different aromatic isomers were compared with those obtained with a column with a similar pillararene stationary phase (permethyl pillar [5]arene, P5A-C10-2NH 2 ), described and characterized in a previous work. 52 As shown in Figure S20, this column does not allow us to reach a baseline separation for chloroaniline, bromoaniline, and toluidine isomers, indicating that the difference in the cavity size of P6A-C10-2NH 2 and P5A-C10-2NH 2 columns plays a key role in the effective separation of aromatic isomers.…”

“…Aromatic amines are extensively used as raw materials or as intermediates in the manufacturing of industrial chemicals such as pharmaceuticals, agrochemicals, polymers, azo dyes, and rubbers. − Aromatic anilines are classified as an important class of environmental pollutants because they are highly toxic to humans and are potential carcinogens. − Due to their high solubility in water, they are easy to penetrate into soil and pollute groundwater, where they have been found at trace levels (<10 μg/L). − For this reason, in this last period, an increasing attention has been devoted to the development of new, reliable, highly selective, sensitive, and rapid analytical methods for their detection, leading to the publication of numerous reports in this field, − exploiting in particular gas chromatography (GC) techniques. − However, direct determination of aromatic aniline isomers using GC techniques is still difficult due to their polar nature; then, aromatic aniline isomers are usually first derivatized and then determined by GC in combination with mass spectrometry (MS) techniques. − Derivatization greatly increases the analysis time and its cost, and it makes use of great amounts of organic solvents, becoming a source of environmental pollution.…”

“…Pillar[n]arenes (P[n]As, n = 5−15) are a new class of macrocyclic host molecules, made by dialkoxybenzene units linked by methylene bridges at 2,5-positions. 36,37 Pillar [5]arene was first synthesized and reported in 2008 by Ogoshi and co-workers. 38 P[n]As possess a highly symmetrical and rigid cavity structure that can be easily functionalized, showing a versatile solubility and high chemical and thermal stabilities.…”

Genome editing of PD-L1 mediated by nucleobase-modified polyamidoamine for cancer immunotherapy

“…24 The large number of amine groups on the surface of PAMAM allows it to compress negatively charged plasmids to form stable nanoparticles via electrostatic interaction. 25 However, too tight binding will hinder the release of nucleic acids in the cytosol and reduce the transfection efficacy. 26 2-Amino-6-chloropurine, a guanine derivative, is a natural ligand that can balance the hydrogen bonding between carriers and nucleic acid molecules.…”

Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol

“…However, the formation of a covalently bonded drug often leads to a decrease in the solubility of the conjugate. The use of the HBP self-assembly technology for noncovalent drug encapsulation in an HBP-based supramolecular matrix is very prospective . In addition, monomolecular HBP micelles exhibit higher stability than micelles of linear amphiphilic block copolymers or dendrimers …”