2022
DOI: 10.1021/acsapm.1c01863
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Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol

Abstract: The study of self-assembly processes in polymer solutions is the basis of a modern strategy for creating targeting systems for various substrates. In turn, the use of binary polymer/surfactant systems makes it possible to expand the range of polymers for creating drug delivery systems. This article describes the processes of formation of hybrid micelles based on carboxylterminal hyperbranched polyester polyol Boltorn H20[BH20-COOH] and surfactant Triton X-100[BH20-COOH/TX-100]. Using pH-metry, conductometry,… Show more

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Cited by 6 publications
(7 citation statements)
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“…While we have observed differences in the drug release profiles, we cannot exclude the possibility of variations in the number of NP-LEV@Staph and NP-CIP@Staph particles adhering to bacteria after the incubation period. Quantifying these targeted nano-antibiotics on the bacterial surface in future experiments is necessary to investigate this aspect further [ 53 , 54 ]. Moreover, conducting in vivo animal studies is essential to gain a more comprehensive understanding of the therapeutic effects of nano-antibiotics.…”
Section: Resultsmentioning
confidence: 99%
“…While we have observed differences in the drug release profiles, we cannot exclude the possibility of variations in the number of NP-LEV@Staph and NP-CIP@Staph particles adhering to bacteria after the incubation period. Quantifying these targeted nano-antibiotics on the bacterial surface in future experiments is necessary to investigate this aspect further [ 53 , 54 ]. Moreover, conducting in vivo animal studies is essential to gain a more comprehensive understanding of the therapeutic effects of nano-antibiotics.…”
Section: Resultsmentioning
confidence: 99%
“…With raising polymer concentration in solution, an increase in the average hydrodynamic diameter of aggregates from D h = 220 ± 25 nm to D h = 605 ± 30 nm and their concentration is observed. This is typical for hyperbranched polyester polyols and their derivatives. …”
Section: Study Of Self-organizationmentioning
confidence: 93%
“…To increase the statistical dose, the sample was pumped through the measuring chamber by using a piezoelectric dispenser. Each sample was detected sequentially six times; the recording time was sequential and amounted to 60 s. For processing the footage of the Nanosight instrument, NTA 2.3 software applications (build 0033) and OriginPro program package were used; the Gaussian function was used throughout, as described previously. , The detailed work is currently presented in the Principle of Operation by Carr and Malloy. , The hydrodynamic size meter ( D h ) was calculated with the measurement of the two-dimensional Einstein–Stokes equation …”
Section: Materials and Methodsmentioning
confidence: 99%
“…To increase the statistical dose, the sample was pumped through the measuring chamber using a piezoelectric dispenser. Each sample was detected sequentially 6 times; the recording time was sequential and amounted to 60 s. For processing the footage of the Nanosight instrument, NTA 2.3 software applications (build 0033) were used as described previously [ 33 , 34 ]. The detailed work is currently presented in the Principle of Operation by B. Carr and A. Malloy [ 35 ].…”
Section: Methodsmentioning
confidence: 99%