Aminergic Control of Social Status in Crayfish Agonistic Encounters

Momohara, Yuto; Kanai, Akihiro; Nagayama, Toshiki

doi:10.1371/journal.pone.0074489

Cited by 44 publications

(48 citation statements)

References 80 publications

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“…After pairing of the two crayfish, the animals started agonistic behaviour, e.g. approach and fighting, and a dominance hierarchy was established within 30 min (Sato and Nagayama 2012;Ueno and Nagayama 2012;Momohara et al 2013). Crayfish that became subordinate almost always showed a retreat or escape tailflip following the dominant animal's attacks during the rest of pairings.…”

Section: Establishment Of Dominant-subordinate Relationshipmentioning

confidence: 99%

“…Since the injection of serotonin into smaller crayfish before pairings with larger opponents increases their winning probability (Momohara et al 2013), the effect of serotonin upon the motor responses to the sensory stimulation was analysed (Fig. 4).…”

Section: Effect Of Serotoninmentioning

confidence: 99%

“…The injection of octopamine into larger crayfish before pairings with smaller opponents decreased the winning probability, although they have a physical advantage during agonistic bouts (Momohara et al 2013). The effect of octopamine on the response of motor neurones to the sensory stimulation was examined (Fig.…”

Section: Effect Of Octopaminementioning

confidence: 99%

“…Although physically larger crayfish are more likely to win (Ueno and Nagayama 2012), serotonin-injected smaller crayfish are more likely to win in pairings with untreated larger animals while octopamine-injected larger crayfish are frequently beaten by untreated smaller crayfish (Momohara et al 2013). Furthermore, the winner effect of previous fights (Daws et al 2002) that winners of the first pairings are more likely to win their subsequent conflicts with larger naive crayfish is cancelled by injection of a serotonin receptor antagonist (Momohara et al 2013). These reports indicate that serotonin appears to affect the social status-dependent behavioural transition from the dart to the turn response.…”

Section: Introductionmentioning

confidence: 99%

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Serotonergic modulation of social status-dependent behavioural plasticity of the crayfish avoidance reaction

2015

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Small crayfish usually showed escape-like dart responses to mechanical stimulation of the tailfan. Following agonistic bouts with conspecifics, dominant crayfish showed a defensive-like turn response to the same sensory stimulus. During the dart response, both uropods closed and animals walked forwards with the abdomen extended, while during the turn response the uropod on the stimulated side opened and animals turned towards the stimulus source with the abdomen frequently flexed. Using an isolated nerve cord preparation, we found that the spike activities of both the abdominal postural and uropod motor neurones in response to sensory stimulation of the exopodite reversed in dominant animals. In naive and subordinate animals, extensor motor neurones were excited and antagonistic flexor motor neurones inhibited in response to sensory stimulation. Furthermore, the spike frequency of uropod closer motor neurones increased while that of the antagonistic opener motor neurones decreased. By contrast, in more than half of the dominant animals, flexor and opener motor neurones showed excitatory responses while extensor and closer motor neurones showed inhibitory responses to the same sensory stimulation. This reverse of activity of the abdominal postural and uropod motor neurones was also observed when serotonin of more than 12.5 μM in concentration was applied.

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Section: Establishment Of Dominant-subordinate Relationshipmentioning

confidence: 99%

Section: Effect Of Serotoninmentioning

confidence: 99%

Section: Effect Of Octopaminementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serotonergic modulation of social status-dependent behavioural plasticity of the crayfish avoidance reaction

2015

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“…Biogenic amines are known to modulate motor outputs of crayfish (e.g. Momohara et al, 2013). For example, octopamine effectively inhibits the expression of swimmeret motor activity (Mulloney et al, 1987).…”

Section: Possible Function Of No In Swimmeret Beatingmentioning

confidence: 99%

Nitric oxide modulates a swimmeret beating rhythm in the crayfish

Mita

Yoshida

Nagayama

2014

Journal of Experimental Biology

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The modulatory effects of nitric oxide (NO) and cAMP on the rhythmic beating activity of the swimmeret motor neurones in the crayfish were examined. Swimmerets are paired appendages located on the ventral side of each abdominal segment that show rhythmic beating activity during forward swimming, postural righting behaviour and egg ventilation in gravid females. In isolated abdominal nerve cord preparations, swimmeret motor neurones are usually silent or show a continuous low-frequency spiking activity. Application of carbachol, a cholinergic agonist, elicited rhythmic bursts of motor neurone spikes. The co-application of L-arginine, the substrate for NO synthesis with carbachol increased the burst frequency of the motor neurones. The co-application of the NO donor SNAP with carbachol also increased the burst frequency of the motor neurones. By contrast, co-application of a NOS inhibitor, L-NAME, with carbachol decreased beating frequency of the motor neurones. These results indicate that NO may act as a neuromodulator to facilitate swimmeret beating activity. The facilitatory effect of L-arginine was cancelled by co-application of the soluble guanylate cyclase (sGC) inhibitor ODQ suggesting that NO acts by activating sGC to promote the production of cGMP. Application of L-arginine alone or membrane-permeable cGMP analogue 8-Br-cGMP alone did not elicit rhythmic activity of motor neurones, but co-application of 8-Br-cGMP with carbachol increased bursting frequency of the motor neurones. Furthermore, application of the membrane-permeable cAMP analogue CPT-cAMP alone produced rhythmic bursting of swimmeret motor neurones, and the bursting frequency elicited by CPT-cAMP was increased by coapplication with L-arginine. Co-application of the adenylate cyclase inhibitor SQ22536 ceased rhythmic bursts of motor neurone spikes elicited by carbachol. These results suggest that a cAMP system enables the rhythmic bursts of motor neurone spikes and that a NO-cGMP signaling pathway increases cAMP activity to facilitate swimmeret beating.

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Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish

Abreu

Maximino

Banha

et al. 2019

J of Neuroscience Research

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Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g., zebrafish) and invertebrate (e.g., crayfish) species, may be relevant to study animal emotional response and its deficits. Ideally, model organisms of disease should possess considerable genetic and physiological homology to mammals, display robust behavioral and physiological responses to stress, and should be sensitive to a wide range of drugs known to modulate stress and affective behaviors. Here, we summarize recent findings in the field of zebrafish‐ and crayfish‐based tests of stress, anxiety, aggressiveness and social preference, and discuss further perspectives of using these novel model organisms in translational biological psychiatry. Outlining the remaining questions in this field, we also emphasize the need in further development and a wider use of crayfish and zebrafish models to study the pathogenesis of affective disorders.

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Aminergic Control of Social Status in Crayfish Agonistic Encounters

Cited by 44 publications

References 80 publications

Serotonergic modulation of social status-dependent behavioural plasticity of the crayfish avoidance reaction

Serotonergic modulation of social status-dependent behavioural plasticity of the crayfish avoidance reaction

Nitric oxide modulates a swimmeret beating rhythm in the crayfish

Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish

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