2018
DOI: 10.1016/j.biomaterials.2018.08.003
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Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications

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Cited by 28 publications
(17 citation statements)
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“…Amino acid-based poly­(ester urea)­s (PEUs) in particular are a class of highly tunable, amorphous degradable polymers that have been shown in vivo to have a limited inflammatory response over several months in a number of promising preclinical studies including tissue engineered vascular grafts, hernia and rotator cuff repair, , and surgical adhesion barriers . PEUs possess a great deal of flexibility in their chemical structure and mechanical properties due to the amino acid side group, the incorporated diol, and the copolymer stoichiometry .…”
Section: Biodegradable Polymers: Materials Selectionmentioning
confidence: 99%
“…Amino acid-based poly­(ester urea)­s (PEUs) in particular are a class of highly tunable, amorphous degradable polymers that have been shown in vivo to have a limited inflammatory response over several months in a number of promising preclinical studies including tissue engineered vascular grafts, hernia and rotator cuff repair, , and surgical adhesion barriers . PEUs possess a great deal of flexibility in their chemical structure and mechanical properties due to the amino acid side group, the incorporated diol, and the copolymer stoichiometry .…”
Section: Biodegradable Polymers: Materials Selectionmentioning
confidence: 99%
“…The hydrolysis (degradation) reaction is modeled by the bond-breaking events, and its acceptance or rejection is governed by the Monte Carlo scheme. In particular, we focus on the effect of hydrophobic and hydrophilic group distribution on degradation of glycine-based poly­(ester urea), valine-based poly­(ester urea), and phenylalanine-based poly­(ester urea) polymers. , …”
Section: Introductionmentioning
confidence: 99%
“…5). The granuloma was less than 200 μm thick for all samples, which has previously been reported as acceptable in terms of tissue compatibility for long-term implants 4,33,34 . This is indicative of the tunable degradation profiles from varied succinate content as increasing implant degradation rates correlates with greater cellular remodeling processes 34 .…”
mentioning
confidence: 50%