Amino acid composition of human scalp hair as a biometric classifier and investigative lead

Rashaid, Ayat Hussein B.; Harrington, Peter de B.; Jackson, Glen P.

doi:10.1039/c4ay02588a

Cited by 23 publications

(26 citation statements)

References 55 publications

(80 reference statements)

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“…12 Recent research has shown that the CSIA δ 13 C values of underivatised amino acids, derived from hydrolysis of hair samples, can indicate metabolic trends associated with factors such as age and obesity in humans. 13,14 While the CSIA approach has yielded important information, it measures the average isotopic information available from amino acids which contain between two (glycine) and 11 (tryptophan) carbon atoms.…”

Section: Introductionmentioning

confidence: 99%

Position‐specific ¹³C/¹²C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Fry

Carter

Yamada

et al. 2018

Rapid Comm Mass Spectrometry

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RationaleThe fundamental level of stable isotopic knowledge lies at specific atomic positions within molecules but existing methods of analysis require lengthy off‐line preparation to reveal this information. An automated position‐specific isotope analysis (PSIA) method is presented to determine the stable carbon isotopic compositions of the carboxyl groups of amino acids (δ 13CCARBOXYL values). This automation makes PSIA measurements easier and routine.MethodsAn existing high‐performance liquid chromatography (HPLC) gas handling interface/stable isotope ratio mass spectrometry system was modified by the addition of a post‐column derivatisation unit between the HPLC system and the interface. The post‐column reaction was optimised to yield CO2 from the carboxyl groups of amino acids by reaction with ninhydrin.ResultsThe methodology described produced δ 13CCARBOXYL values with typical standard deviations below ±0.1 ‰ and consistent differences (Δ 13CCARBOXYL values) between amino acids over a 1‐year period. First estimates are presented for the δ 13CCARBOXYL values of a number of internationally available amino acid reference materials.ConclusionsThe PSIA methodology described provides a further dimension to the stable isotopic characterisation of amino acids at a more detailed level than the bulk or averaged whole‐molecule level. When combined with on‐line chromatographic separation or off‐line fraction collection of protein hydrolysates the technique will offer an automated and routine way to study position‐specific carboxyl carbon isotope information for amino acids, enabling more refined isotopic studies of carbon uptake and metabolism.

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Section: Introductionmentioning

confidence: 99%

Position‐specific ¹³C/¹²C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Fry

Carter

Yamada

et al. 2018

Rapid Comm Mass Spectrometry

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“…An attractive aspect of hair sampling over conventional excretory human body systems, such as blood, sweat, and urine, is that hair is easier to store, transport, and handle. Hair is relatively stable, possessing a reduced risk of deterioration over time, making this characteristic relevant to forensic analysis …”

Section: Introductionmentioning

confidence: 99%

“…Hair is relatively stable, possessing a reduced risk of deterioration over time, making this characteristic relevant to forensic analysis. [4,5] In the literature, numerous studies about hair analysis have been increased over time, especially in the toxicological, clinical, and doping control area. However, there are other applications that use hair for the investigation of illegal drugs.…”

Section: Introductionmentioning

confidence: 99%

Wavelength dispersive X‐ray fluorescence (WDXRF) and chemometric investigation of human hair after cosmetic treatment

Santos¹,

Sperança

Pereira³

2018

X-Ray Spectrometry

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Variations in the chemical composition of 63 different human and 6 different synthetic hair samples were investigated using wavelength dispersive X‐ray fluorescence (WDXRF) spectra profiles. To evaluate the effect of cosmetic treatment on the strands, the human hair samples were bleached, but the synthetic ones were not. To better investigate the data, exploratory analyses were calculated using principal component analysis for the WDXRF spectra. Eight normalizations/standardizations were applied in the WDXRF to verify the clustering tendency. Bleaching was tested, because it is one way in which people mask their real hair color. After the data were standardized, an enhancement of the data discrimination was verified. Furthermore, the explained variance was higher in the first principal components. The WDXRF spectra were able to distinguish samples with distinct features, including synthetic, dyed, and straightened hair. The findings of this study hold promise for forensics due to desirable aspects such as nondestructivity and the possibility of a large hair sample database.

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“…At a crime scene, traces collected from hairs, clothes or carpets fibers, soil, and pieces of glass (3)(4)(5)(6) can shed light on events of the crime, and provide information about who was present before and after an unlawful act. Traditionally, both DNA and fingerprints at crime scene are used to identify a suspect with a high degree of certainty.…”

mentioning

confidence: 99%

Lifestyle chemistries from phones for individual profiling

Bouslimani

Melnik

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Imagine a scenario where personal belongings such as pens, keys, phones, or handbags are found at an investigative site. It is often valuable to the investigative team that is trying to trace back the belongings to an individual to understand their personal habits, even when DNA evidence is also available. Here, we develop an approach to translate chemistries recovered from personal objects such as phones into a lifestyle sketch of the owner, using mass spectrometry and informatics approaches. Our results show that phones' chemistries reflect a personalized lifestyle profile. The collective repertoire of molecules found on these objects provides a sketch of the lifestyle of an individual by highlighting the type of hygiene/beauty products the person uses, diet, medical status, and even the location where this person may have been. These findings introduce an additional form of trace evidence from skin-associated lifestyle chemicals found on personal belongings. Such information could help a criminal investigator narrowing down the owner of an object found at a crime scene, such as a suspect or missing person.skin | phones | lifestyle chemistries | trace evidence

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Amino acid composition of human scalp hair as a biometric classifier and investigative lead

Abstract: Hair shaft analysis is becoming increasingly important in clinical applications and forensic science.

Cited by 23 publications

References 55 publications

Position‐specific ¹³C/¹²C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Position‐specific ¹³C/¹²C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Wavelength dispersive X‐ray fluorescence (WDXRF) and chemometric investigation of human hair after cosmetic treatment

Lifestyle chemistries from phones for individual profiling

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Amino acid composition of human scalp hair as a biometric classifier and investigative lead

Abstract: Hair shaft analysis is becoming increasingly important in clinical applications and forensic science.

Cited by 23 publications

References 55 publications

Position‐specific 13C/12C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Position‐specific 13C/12C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Wavelength dispersive X‐ray fluorescence (WDXRF) and chemometric investigation of human hair after cosmetic treatment

Lifestyle chemistries from phones for individual profiling

Contact Info

Product

Resources

About

Position‐specific ¹³C/¹²C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin

Position‐specific ¹³C/¹²C analysis of amino acid carboxyl groups – automated flow‐injection analysis based on reaction with ninhydrin