Amino-acid Content of the Blood Following Intravenous Injection of Hydrolyzed Casein

Elman, Robert

doi:10.3181/00379727-37-9599

Cited by 43 publications

(13 citation statements)

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“…Continuous glucose infusion was described in 1924 following description of dose–response curves to intravenous glucose infusions 24,25 . Development in the technique of protein hydrolyzation provided the opportunity for the intravenous delivery of amino acids 26 . The success was initially documented in goats following intravenous administration of hydrolyzed beef protein 23 .…”

Section: The History Of Management Of Intestinal Failurementioning

confidence: 99%

“…The success was initially documented in goats following intravenous administration of hydrolyzed beef protein 23 . Dr. Robert Elman was the first to demonstrate that intravenous amino acid solutions, based on an enzymatic extract of casein and pancreas, could be safely and effectively administered to patients 26 . Crystalline L‐amino acid solutions provided added advantages including the ability to enhance and vary the amino acid profile of solutions.…”

Section: The History Of Management Of Intestinal Failurementioning

confidence: 99%

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Intestinal failure: A new era in clinical management

Bines

2009

J of Gastro and Hepatol

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Only 50 years ago intestinal failure was considered incompatible with life. Since then, developments in parenteral nutrition, and, more recently, small intestinal transplantation, have provided new therapeutic options with the potential to offer long-term survival with a good quality of life. Current medical and surgical strategies are aimed at enhancing intestinal adaptation, improving absorption to achieve nutritional independence, and minimizing the complications of parenteral nutrition therapy. An integrated, multidisciplinary approach to the management of patients with intestinal failure, closely linked to a transplantation program to facilitate early referral, is recognized as a key factor in optimizing patient outcomes.

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Section: The History Of Management Of Intestinal Failurementioning

confidence: 99%

Section: The History Of Management Of Intestinal Failurementioning

confidence: 99%

Intestinal failure: A new era in clinical management

Bines

2009

J of Gastro and Hepatol

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“…Although before Dr Elman there had been reports of successful intravenous infusions of amino acids in goats, his seminal contribution was the demonstration that amino acids could be effectively and safely administered intravenously to humans [13,16,18]. The amino acid solutions were prepared as an enzymatic hydrolysate of casein and pancreas.…”

Section: The Development Of Modern Parenteral Nutritionmentioning

confidence: 99%

The History of Intestinal Failure and Transplantation

Langnas

2008

Intestinal Failure

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“…The origins of "modern" PN can be traced to the publication in 1937 by Robert Elman [1] of his successful studies in humans of intravenous amino acid infusion in the form of protein hydrolysates. However, even at this time there were skeptics who argued that the infusion of amino acids that circumvented the liver was "unphysiologic" and probably "toxic to the brain and other organs" [2].…”

Section: Introductionmentioning

confidence: 99%

Maximizing efficacy from parenteral nutrition in critical care: Appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources

Marik

2007

Curr Gastroenterol Rep

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The gastrointestinal tract is the preferred route for nutritional support in hospitalized patients. Patients with a functioning gastrointestinal tract, including those with pancreatitis or inflammatory bowel disease and those receiving chemotherapy, should be fed enterally. Parenteral nutrition (PN) should be limited to patients with gastrointestinal failure, including those with short gut syndrome, high-output fistula, prolonged ileus, or bowel obstruction. PN is associated with numerous complications, most notably increased risk of serious infection. Emerging data suggest that immunologic complications of PN may result from hyperglycemia and use of n-6 polyunsaturated fatty acids. Safety may be improved with a low-calorie formula and ensuring tight glycemic control with an insulin protocol. A lipid emulsion containing fish oil, olive oil, or both should replace soybean-containing emulsions. Supplemental glutamine, 0.2 g/kg/d to 0.5 g/kg/d, has been shown to reduce the risk of infection and to improve glycemic control.

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Amino-acid Content of the Blood Following Intravenous Injection of Hydrolyzed Casein

Cited by 43 publications

References 0 publications

Intestinal failure: A new era in clinical management

Intestinal failure: A new era in clinical management

The History of Intestinal Failure and Transplantation

Maximizing efficacy from parenteral nutrition in critical care: Appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources

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