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The work presented in this paper is an outgrowth of a previous study made in this clinic (1) and deals with the use of a relatively simple method by which red cells containing radioactive phosphorus (P32) are used to measure blood volume in human subjects. Observations were also made on blood volume changes as measured by the effect of an intravenous injection of plasma and pure human albumin. PREVIOUS OBSERVATIONSMethods proposed for the determination of blood volume include both direct and indirect means. Complete historical reviews of these various methods have been reported by Keith, Rowntree and Geraghty (2) and by Erlanger (3). More recently Gregersen (4) and Gibson (5) summarized their results with the dye dilution method in normal and pathological conditions.With the advent of radioactive tracer elements for use in biology and medicine, a new tool became available. Two radioactive isotopes (iron and phosphorus) have been employed to date.

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