Value of Blood Amylase Estimations in the Diagnosis of Pancreatic Disease

Elman, Robert

doi:10.1001/archsurg.1929.01150060005001

Cited by 138 publications

(43 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 However, an accepted criterion standard for the diagnosis of pancreatitis other than direct visualization does not exist. Although plasma amylase and lipase historically have been used for the diagnosis of pancreatitis, 1,7 they may be normal in up to 20% of cases, 1,4,6 and although lipase may be a more accurate measure of pancreatitis, 8 neither is considered a definitive test for pancreatitis. 9 Contrastenhanced abdominal computed tomography (CT) is considered the most accurate noninvasive test for pancreatitis 6,10 but is expensive, not universally available, contraindicated in those with allergies to contrast agents, and carries the risk of ionizing radiation and contrastinduced nephropathy.…”

mentioning

confidence: 99%

Point-of-care Urine Trypsinogen Testing for the Diagnosis of Pancreatitis

et al. 2007

View full text Add to dashboard Cite

Objectives: To assess a point-of-care (POC) urine trypsinogen (UT) test for the diagnosis of pancreatitis in the emergency department (ED).Methods: This was a prospective cohort study of a convenience sample of patients presenting to the ED with abdominal pain or symptoms suggestive of pancreatitis. A 3-minute POC UT test (Actim Pancreatitis; Medix Biochemica, Kauniainen, Finland) was compared with plasma lipase and amylase measurements, imaging results when performed, and final discharge diagnoses. The criterion standard was a final discharge diagnosis of acute pancreatitis.Results: Of 191 patients included in this study, 17 patients were diagnosed with either acute or acute-onchronic pancreatitis. The sensitivity and specificity of UT for acute pancreatitis were, respectively, 100% (95% confidence interval [CI] = 77% to 100%) and 96% (95% CI = 92% to 98%). Seven of the 17 patients with pancreatitis (41%) had diagnostic findings on CT and positive UT tests but had nondiagnostic plasma lipase and amylase levels. Conclusions:A POC UT screening test for pancreatitis in the ED compared favorably with plasma lipase and amylase levels. Future studies should be performed to explore whether this test in the ED setting has better clinical utility than plasma lipase or amylase.

show abstract

mentioning

confidence: 99%

Point-of-care Urine Trypsinogen Testing for the Diagnosis of Pancreatitis

et al. 2007

View full text Add to dashboard Cite

show abstract

“…[1] All the descriptions of pancreatitis reflected severe onset of the disease, until 1929, when Elman, a surgical resident working under Professor Evarts Graham, reported the value of blood amylase in acute pancreatitis. [2] After his report, identification and prediction of severe cases emerged as the next problem. Scoring systems such as Ranson, Imrie, Glasgow, and the Acute Physiology and Chronic Health Evaluation (APACHE II) are used for prediction of disease severity, but these scoring systems require up to 48 hours (h).…”

Section: Resultsmentioning

confidence: 99%

Alpha-1 protease inhibitor and antichymotrypsin levels in acute pancreatitis

Karsidag¹,

Tüzün²,

Kemik³

et al. 2012

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

AMAÇŞiddetli formundaki yüksek mortalite oranı ile akut pankreatit günümüzde halen tıbbın önemli bir sorunudur. Hastalığın şiddetinin erken belirlenmesi etkin tedavi için kritik öneme sahiptir. Çeşitli biyokimyasal belirteçler denenmiştir ve halen denenmektedir. İdeal belirteç olguyu tanı-yabilmeli ve pankreatitin hafif ve şiddetli formlarını ayırt edebilmelidir. GEREÇ VE YÖNTEMBu prospektif çalışmaya akut pankreatitli 34 olgu (14 erkek, 20 kadın, ort. yaş: 58 yaş) ve kontrol grubundaki 33 olgu (17 erkek, 16 kadın, ort. yaş: 53 yaş) dahil edildi. Hafif (n=29) ve ağır (n=5) olgular başvuru anındaki, başvuru-dan 24 ve 48 saat sonraki amilaz, C-reaktif protein (CRP), alfa-1 proteaz inhibitörü ve antikimotripsin düzeyleri açı-sından karşılaştırıldı. BULGULARAkut pankreatit grubunda alfa-1 proteaz inhibitörü ve antikimotripsinin serum düzeyleri ilk 24 saatte yükseldi, buna karşın CRP 48 saat sonra pik değere ulaştı. CRP şiddet-li pankreatitli hastalarda anlamlı derecede yüksek konsantrasyonlar gösterirken, alfa-1 proteaz inhibitörü ve antikimotripsin düzeylerindeki hafif değişimler anlamlı değildi. SONUÇBaşvuru anında yüksek düzeyleri ile alfa-1 proteaz inhibitörü ve antikimotripsin akut pankreatitte erken sonuçlar verir. Bu değişkenlerin aktivasyonları 24 saat sonra düşer. Bu belirteçlerin akut pankreatitli hastalarda erken tanı değeri olabilir. Her ikisi de bu hastalığın hafif ve şiddetli olgularını ayırmada iyi olmadığından, rutin klinik kullanıma dahil edilmemelidir.Anahtar Sözcükler: Alfa-1 proteaz inhibitor; antikimotripsin; akut pankreatit.

show abstract

“…The measurement of serum amylase has been the cornerstone in the diagnosis of acute pancreatitis since 1929. 6 There are over 200 different assays for the enzyme and no upper limit of normal values has been set. Although serum amylase is considered the most practical test in the diagnosis of acute pancreatitis, yet it poses various problems in the diagnosis of acute pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on Sensitivity of Serum and Urinary Amylase in the Diagnosis of Acute Pancreatitis

Gupta¹

2017

jmscr

View full text Add to dashboard Cite

Value of Blood Amylase Estimations in the Diagnosis of Pancreatic Disease

Cited by 138 publications

References 14 publications

Point-of-care Urine Trypsinogen Testing for the Diagnosis of Pancreatitis

Point-of-care Urine Trypsinogen Testing for the Diagnosis of Pancreatitis

Alpha-1 protease inhibitor and antichymotrypsin levels in acute pancreatitis

Comparative Study on Sensitivity of Serum and Urinary Amylase in the Diagnosis of Acute Pancreatitis

Contact Info

Product

Resources

About