Amino-Acid Patterns in Vitamin A-deficient Rats

Malathi, P.; Ps, Sastry; Ganguly, J.

doi:10.1038/189660a0

Cited by 14 publications

(8 citation statements)

References 7 publications

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“…We have shown that vitamin A deficiency causes a marked decrease in the synthesis of ascorbate and in the p-hydroxyphenylpyruvate-oxidase activity in rats; the latter could only partially be corrected by the administration or addition in vitro of ascorbate, although injection of ascorbate normalizes the increased concentrations of phenolic amino acids in the tissues of the vitamin A-deficient rats (Malathi & Ganguly, 1964).…”

Section: Discussionmentioning

confidence: 88%

“…The ubiquinone concentration in the liver of vitamin A-deficient rats is markedly increased (Lowe, Morton & Harrison, 1953;Morton & Phillips, 1959), and in the liver of such rats the incorporation of [2-_4C]mevalonate is higher in the squalene and ubiquinone fractions and lower in the sterol fraction (Gloor & Wiss, 1959a, b). The concentrations of free phenylalanine and tyrosine in the tissues of vitamin A-deficient rats are higher (Malathi, Seshadri Sastry & Ganguly, 1961) and can be corrected by the administration of ascorbate (Malathi & Ganguly, 1964). Possibly, therefore, one of the reasons for the increased concentration of ubiquinones in the liver of the vitamin A-deficient rats is the availability of larger amounts of the phenolic amino acids.…”

mentioning

confidence: 99%

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Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats

Malathi¹,

Ganguly²

1964

Biochemical Journal

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Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 99%

Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats

Malathi¹,

Ganguly²

1964

Biochemical Journal

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“…Plasma free amino acids were determined at the end of the experiment (28 d of age). No change was caused by vitamin A deficiency in the concentration of total free amino acids or in the concentrations of phenylalanine and tyrosine, which have been reported to be increased in the rat (Malathi, Seshadri Sastry & Ganguly, 1961).…”

Section: Vol 3mentioning

confidence: 94%

Effect of vitamin A deficiency on protein catabolism in chicks

1974

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1. The changes in the concentration of some enzymes and their metabolites were studied in the first stages of vitamin A deficiency in chicks.2. Kidney arginase (EC3.5.3.1) and liver xanthine dehydrogenase activities had increased even before complete disappearance of vitamin A from the plasma. Similarly, an increase was found in plasma uric acid, and plasma urea also increased but to a lesser extent. Liver proteolytic activity also was slightly increased by vitamin A deficiency.3. Kidney D-amino acid oxidase (EC1.4.3.3) activity and plasma concentrations of total protein and free amino acids were not affected, at least in the first stages of the deficiency.4. Oral dosing of deficient chicks with retinyl palmitate to provide 300 μg retinol, 24 h before killing, brought about a decrease in the activities of both enzymes and of plasma uric acid, and an increase in plasma urea.5. Dietary levels of vitamin A were reflected not only in the liver concentrations of the vitamin but also in the plasma concentrations.

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“…The increased activities of these enzymes observed in this study suggests that the conversion of glyoxylate to oxalate is increased in vitamin A deficiency. Malathi et al [19] found increased concentrations of free phenylalanine and tyrosine in blood, liver and kidneys of rats fed a vitamin A-deficiency diet. Gamberdella and Richardson [20] demonstrated that phenylalanine and tyrosine are converted to oxalate via glycolate.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin A Deficiency on the Specific Activities of Oxalate-Synthesizing Enzymes.

Kancha

Anasuya

1991

J. Clin. Biochem. Nutr.

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SummaryTo investigate the cause of hyperoxaluria in vitamin A deficiency, we studied the specific activities of the major oxalatesynthesizing enzymes in the liver, viz., glycolic acid oxidase (GAO), glycolic acid dehydrogenase (GAD), and lactate dehydrogenase (LDH). Pair-fed control and experimental (vitamin A deficient) groups of rats were fed a high-calcium (9g/kg diet), calculogenic diet for 12 weeks. Vitamin A deficiency resulted in increased specific activities of GAO, GAD (p<0.001), and LDH (p<0.05) compared with those of pair-fed controls. Correction of vitamin A deficiency returned the enzyme activities to the levels observed in control animals. The possible biochemical mechanism of hyperoxaluria in vitamin A deficiency is discussed.

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Amino-Acid Patterns in Vitamin A-deficient Rats

Cited by 14 publications

References 7 publications

Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats

Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats

Effect of vitamin A deficiency on protein catabolism in chicks

Effect of Vitamin A Deficiency on the Specific Activities of Oxalate-Synthesizing Enzymes.

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