Amino acid profile and metabolic syndrome in a male Mediterranean population: A cross-sectional study

Ntzouvani, Agathi; Nomikos, Tzortzis; Panagiotakos, D.; Fragopoulou, Elisabeth; Pitsavos, Christos; McCann, Adrian; Ueland, Per Magne; Antonopoulou, Smaragdi

doi:10.1016/j.numecd.2017.07.006

Cited by 63 publications

(57 citation statements)

References 35 publications

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“… 31 , 32 However, an excess amount of free BCAA or their catabolic products can also be cytotoxic. 28 Elevated concentrations of each or total BCAA were found in individuals with cardiovascular risk factors, such as high fasting blood glucose, dyslipidemia, or increased serum atherosclerosis index (ratio between serum triglycerides and high-density lipoproteins [HDL]), in patients with diagnosed CAD, 8 , 33 , 34 in men with metabolic syndrome risk, 35 or in healthy individuals, independently of their BMI. 36 Moreover, BCAA were shown to be predictors for hypertriglyceridemia in early adulthood.…”

Section: Branched-chain Amino Acid As Biomarkers For Cvd Riskmentioning

confidence: 99%

Specific Amino Acids Affect Cardiovascular Diseases and Atherogenesis via Protection against Macrophage Foam Cell Formation: Review Article

Grajeda‐Iglesias¹,

Aviram²

2018

Rambam Maimonides Med J

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The strong relationship between cardiovascular diseases (CVD), atherosclerosis, and endogenous or exogenous lipids has been recognized for decades, underestimating the contribution of other dietary components, such as amino acids, to the initiation of the underlying inflammatory disease. Recently, specific amino acids have been associated with incident cardiovascular disorders, suggesting their significant role in the pathogenesis of CVD. Special attention has been paid to the group of branched-chain amino acids (BCAA), leucine, isoleucine, and valine, since their plasma values are frequently found in high concentrations in individuals with CVD risk. Nevertheless, dietary BCAA, leucine in particular, have been associated with improved indicators of atherosclerosis. Therefore, their potential role in the process of atherogenesis and concomitant CVD development remains unclear. Macrophages play pivotal roles in the development of atherosclerosis. They can accumulate high amounts of circulating lipids, through a process known as macrophage foam cell formation, and initiate the atherogenesis process. We have recently screened for anti- or pro-atherogenic amino acids in the macrophage model system. Our study showed that glycine, cysteine, alanine, leucine, glutamate, and glutamine significantly affected macrophage atherogenicity mainly through modulation of the cellular triglyceride metabolism. The anti-atherogenic properties of glycine and leucine, and the pro-atherogenic effects of glutamine, were also confirmed in vivo. Further investigation is warranted to define the role of these amino acids in atherosclerosis and CVD, which may serve as a basis for the development of anti-atherogenic nutritional and therapeutic approaches.

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Section: Branched-chain Amino Acid As Biomarkers For Cvd Riskmentioning

confidence: 99%

Specific Amino Acids Affect Cardiovascular Diseases and Atherogenesis via Protection against Macrophage Foam Cell Formation: Review Article

Grajeda‐Iglesias¹,

Aviram²

2018

Rambam Maimonides Med J

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“…However, these studies generally focused on a single component of the metabolic syndrome and investigated a limited number of metabolites. To the best of our knowledge, only 1 study examined the association between concentrations of several amino acids and the metabolic syndrome (Ntzouvani et al 2017 ). The assessment of the heterogeneous population of metabolic syndrome patients could potentially highlight a common biochemical mechanism of importance for multiple cardiometabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

et al. 2019

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Background We aimed to identify novel metabolite and lipid signatures connected with the metabolic syndrome in a Dutch middle-aged population. Methods 115 individuals with a metabolic syndrome score ranging from 0 to 5 [50 cases of the metabolic syndrome (score ≥ 3) and 65 controls] were enrolled from the Leiden Longevity Study, and LC/GC–MS metabolomics and lipidomics profiling were performed on fasting plasma samples. Data were analysed with principal component analysis and orthogonal projections to latent structures (OPLS) to study metabolite/lipid signatures associated with the metabolic syndrome. In addition, univariate analyses were done with linear regression, adjusted for age and sex, for the study of individual metabolites/lipids in relation to the metabolic syndrome. Results Data was available on 103 metabolites and 223 lipids. In the OPLS model with metabolic syndrome score (Y-variable), 9 metabolites were negatively correlated and 26 metabolites (mostly acylcarnitines, amino acids and keto acids) were positively correlated with the metabolic syndrome score. In addition, a total of 100 lipids (mainly triacylglycerides) were positively correlated and 10 lipids from different lipid classes were negatively correlated with the metabolic syndrome score. In the univariate analyses, the metabolic syndrome (score) was associated with multiple individual metabolites (e.g., valeryl carnitine, pyruvic acid, lactic acid, alanine) and lipids [e.g., diglyceride(34:1), diglyceride(36:2)]. Conclusion In this first study on metabolomics/lipidomics of the metabolic syndrome, we identified multiple novel metabolite and lipid signatures, from different chemical classes, that were connected to the metabolic syndrome and are of interest to cardiometabolic disease biology. Electronic supplementary material The online version of this article (10.1007/s11306-019-1484-7) contains supplementary material, which is available to authorized users.

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“…Alterations in amino acid metabolism have been linked with hypertension in nonpregnant populations [61], and specific combined amino acid pathways (such as forglycine/serine/alanine/threonine) have also been found to be significantly altered with metabolic syndrome [62]. In pregnancy, many of the amino acid pathways we found to be associated with gHTN have been associated with PE in other studies, including arginine, alanine, serine, glycine, and asparagine [11,14,63].…”

Section: Discussionmentioning

confidence: 77%

Early Pregnancy Serum Metabolite Profiles Associated with Hypertensive Disorders of Pregnancy in African American Women: A Pilot Study

Ferranti

Frediani

Mitchell

et al. 2020

Journal of Pregnancy

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Hypertensive disorders of pregnancy (HDP) are the most common cardiometabolic complications of pregnancy, affecting nearly 10% of US pregnancies and contributing substantially to maternal and infant morbidity and mortality. In the US, women of African American race are at increased risk for HDP. Early biomarkers that reliably identify women at risk for HDP remain elusive, yet are essential for the early identification and targeting of interventions to improve maternal and infant outcomes. We employed high-resolution metabolomics (HRM) to identify metabolites and metabolic pathways that were altered in early (8-14 weeks) gestation serum samples of pregnant African American women who developed HDP after 20 weeks’ gestation (n=20)—either preeclampsia (PE; n=11) or gestational hypertension (gHTN; n=9)—compared to those who delivered full term without complications (n=80). We found four metabolic pathways that were significantly (p<0.05) altered in women who developed PE and five pathways that were significantly (p<0.05) altered in women who developed gHTN compared to women who delivered full term without complications. We also found that four specific metabolites (p<0.05) were distinctly upregulated (retinoate, kynurenine) or downregulated (SN-glycero-3-phosphocholine, 2′4′-dihydroxyacetophenone) in women who developed PE compared to gHTN. These findings support that there are systemic metabolic disruptions that are detectable in early pregnancy (8-14 weeks of gestation) among pregnant African American women who develop PE and gHTN. Furthermore, the early pregnancy metabolic disruptions associated with PE and gHTN are distinct, implying they are unique entities rather than conditions along a spectrum of the same disease process despite the common clinical feature of high blood pressure.

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Amino acid profile and metabolic syndrome in a male Mediterranean population: A cross-sectional study

Cited by 63 publications

References 35 publications

Specific Amino Acids Affect Cardiovascular Diseases and Atherogenesis via Protection against Macrophage Foam Cell Formation: Review Article

Specific Amino Acids Affect Cardiovascular Diseases and Atherogenesis via Protection against Macrophage Foam Cell Formation: Review Article

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

Early Pregnancy Serum Metabolite Profiles Associated with Hypertensive Disorders of Pregnancy in African American Women: A Pilot Study

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