Amino acids nanocrystals for piezoelectric detection of ultra-low mechanical pressure

Bishara, Hanna; Nagel, Alina; Levanon, Maya; Berger, S.

doi:10.1016/j.msec.2019.110468

Cited by 18 publications

(17 citation statements)

References 59 publications

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“…[265] Biological ferroelectric materials have great potential in biosensing and disease diagnosis and treatment, in particular, to produce biodegradable sensors for applications in wearable biomedical diagnostics. [85,234,266,267] For example, flexible pressure sensors based on free-standing and biodegradable glycineÀ chitosan piezoelectric films were fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution. These piezoelectric films consisted of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.…”

Section: Physical Propertiesmentioning

confidence: 99%

“…Piezoelectricity enables detection of pressure by a change of dielectric polarization when the material is subjected to external pressure. [266] The application of controlled mechanical stress on a wound site can accelerate the wound healing by improving the cellular proliferation during tissue regeneration. [271] To facilitate this there is need to monitor the applied stress around the wound site and hence there is need to develop a biocompatible stress sensor.…”

Section: Physical Propertiesmentioning

confidence: 99%

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Glycine: The Gift that Keeps on Giving

Boldyreva

2021

Israel Journal of Chemistry

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Glycine is a small molecule. It cannot change its conformation and is achiral. Despite the apparent simplicity, glycine shows endless diversity in its behavior over many phenomena. It was the first amino acid for which polymorphism was reported, first on crystallization and then on hydrostatic compression. The polymorphs differ in their physical properties and their biological activity. Glycine clusters persist in solution, leading to "solution memory". Phenomena at interfaces are critically important for crystal growth, dissolution, and for physical properties, which can be at times unexpected, like polarity in centrosymmetric αpolymorph. It is a great pleasure to remind of these remarkable phenomena in a special issue honoring professors Meir Lahav and Leslie Leiserowitz, who pioneered the study of the behavior of this unique molecule in many respects, and showed how complex and non-trivial phenomena can be at interfaces: between phases and between research fields.

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Section: Physical Propertiesmentioning

confidence: 99%

Section: Physical Propertiesmentioning

confidence: 99%

Glycine: The Gift that Keeps on Giving

Boldyreva

2021

Israel Journal of Chemistry

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“…Polarization switching was performed by applying DC voltage to the PFM tip at the nanoscale and switchable domains were shown to persist for a long time. That work attracted a wide interest of the research community in different fields and has launched a new round of experimental and theoretical studies of glycine (Bystrov et al, 2014;Bystrov et al, 2015;Bystrov et al, 2016;Guerin et al, 2017;Seyedhosseini et al, 2017;Bai et al, 2018;Tasnim et al, 2018;Hu et al, 2019;Slabov et al, 2019;Bishara et al, 2020;Dishon et al, 2020;Gleeson et al, 2020;Hosseini et al, 2020;Kholkin et al, 2021). Several reviews reported piezoelectric properties of glycine (Tayi et al, 2015;Tofail and Bauer, 2016;Guerin et al, 2017;Maiti et al, 2019;Kim et al, 2020;Li et al, 2020;Boldyreva, 2021;Xu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Ferroelectricity in glycine: A mini-review

et al. 2022

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Glycine is the simplest natural amino acid, a basic building block for various biomaterials. Supramolecular packing of glycine molecules into three main crystalline polymorphs allows controlling their functional properties, such as piezoelectricity and ferroelectricity. Though piezoelectricity in glycine is well studied and reviewed, its ferroelectric properties were not summarized and analyzed until now. In this mini-review, we briefly discuss glycine polymorphs, their functional properties, and phase transitions, review recent findings on domain structure and polarization switching in β- and γ-glycine, and consider their possible applications in biocompatible photonic and piezoelectric devices.

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“…We have recently demonstrated this using a flexible glycine-based energy harvester that can be used as a structural health monitor to detect leaks in water infrastructure networks (Okosun et al, 2021). Amino acids have also been utilised to detect ultra-low mechanical pressures (Bishara et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Ab-Initio Predictions of the Energy Harvesting Performance of L-Arginine and L-Valine Single Crystals

Guerin

2021

Front. Mech. Eng.

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Biological piezoelectric materials are beginning to gain attention for their huge potential as eco-friendly energy harvesting materials. In particular, simple amino acid and peptide crystal assemblies are demonstrating large voltage outputs under applied force, and high sensitivity when detecting vibrations. Here we utilise Density Functional Theory (DFT) calculations to quantitatively predict the energy harvesting properties of two understudied proteinogenic amino acid crystals: L-Arginine and L-Valine. The work highlights the ability of quantum mechanical calculations to screen crystals as high-performance energy harvesters, and demonstrates the capability of small biological crystals as eco-friendly piezoelectric materials. L-Arginine is predicted to have a maximum piezoelectric voltage constant of gij = 274 mV m/N, with a Young’s Modulus of E = 17.1 GPa. L-Valine has a maximum predicted piezoelectric voltage constant of gij = 62 mV m/N, with a calculated Young’s Modulus of E = 19.8 GPa.

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Amino acids nanocrystals for piezoelectric detection of ultra-low mechanical pressure

Cited by 18 publications

References 59 publications

Glycine: The Gift that Keeps on Giving

Glycine: The Gift that Keeps on Giving

Ferroelectricity in glycine: A mini-review

Ab-Initio Predictions of the Energy Harvesting Performance of L-Arginine and L-Valine Single Crystals

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