Amino-modified-silica-coated gadolinium-copper nanoclusters, conjugated to AS1411 aptamer and radiolabeled with technetium-99 m as a novel multimodal imaging agent

Najdian, Atena; Amanlou, Massoud; Beiki, Davood; Bitarafan-Rajabi, Ahmad; Mirzaei, Mehdi; Ardestani, Mehdi Shafiee

doi:10.1016/j.bioorg.2022.105827

Cited by 16 publications

(2 citation statements)

References 61 publications

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“…By introducing DNA-mediated multi-mode methods, we expect to improve the spatial resolution and provide accurate quantification for biological imaging analysis. Currently, the applications of DNA-mediated multi-mode methods for bioimaging analysis mainly include the combination mode of quantification-bioimaging (e.g., SERS/FL [146], FL/MR [147], etc.) and multiple imaging mode (e.g., SERS/MR [148], FL/CT/MR [149], etc.…”

Section: Bioimaging Analysismentioning

confidence: 99%

Recent Advances in the DNA-Mediated Multi-Mode Analytical Methods for Biological Samples

Huang

Zhang

2023

Biosensors

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DNA-mediated nanotechnology has become a research hot spot in recent decades and is widely used in the field of biosensing analysis due to its distinctive properties of precise programmability, easy synthesis and high stability. Multi-mode analytical methods can provide sensitive, accurate and complementary analytical information by merging two or more detection techniques with higher analytical throughput and efficiency. Currently, the development of DNA-mediated multi-mode analytical methods by integrating DNA-mediated nanotechnology with multi-mode analytical methods has been proved to be an effective assay for greatly enhancing the selectivity, sensitivity and accuracy, as well as detection throughput, for complex biological analysis. In this paper, the recent progress in the preparation of typical DNA-mediated multi-mode probes is reviewed from the aspect of deoxyribozyme, aptamer, templated-DNA and G-quadruplex-mediated strategies. Then, the advances in DNA-mediated multi-mode analytical methods for biological samples are summarized in detail. Moreover, the corresponding current applications for biomarker analysis, bioimaging analysis and biological monitoring are introduced. Finally, a proper summary is given and future prospective trends are discussed, hopefully providing useful information to the readers in this research field.

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Section: Bioimaging Analysismentioning

confidence: 99%

Recent Advances in the DNA-Mediated Multi-Mode Analytical Methods for Biological Samples

Huang

Zhang

2023

Biosensors

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“…They can be easily conjugated with different imaging agents, including uorescent dyes, radionuclides, paramagnetic agents, and nanoparticles, thereby enabling multimodal imaging approaches. [218][219][220] This versatility allows for the combination of different imaging modalities to obtain complementary information and improve the accuracy and sensitivity of disease detection and monitoring.…”

Section: Multimodalitymentioning

confidence: 99%

Engineered aptamers for molecular imaging

Lin,

Xiao,

Jiang

et al. 2023

Chem. Sci.

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Design and Application of Nuclear and Molecular Theragnostic Probes

Sharma,

Chaturvedi,

Kaul

et al. 2024

ChemistrySelect

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With growing propensity towards personalised medication, the application and impact of molecular theragnostic (or, theranostic) is expected to increase dramatically. Molecular theragnostic is the combination of diagnostics and therapeutics in single targeted molecule. If successful, molecular theragnostic will determine the treatment strategy and therapeutic outcome apart from favourably influencing the time of treatment and comfort of the patient. Recent developments such as [64Cu]Cu‐ATSM for imaging tumor‐hypoxia, 99Y silicate for arthritis, 1⁷⁷Lu‐PSMA‐617 for prostate cancer etc has been discussed in detail in the literature.[1,2] This sectioned review deals in particular with the development of nuclear molecular theragnostic agents. The genesis and design strategies are presented after compiling recent reports.

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Amino-modified-silica-coated gadolinium-copper nanoclusters, conjugated to AS1411 aptamer and radiolabeled with technetium-99 m as a novel multimodal imaging agent

Cited by 16 publications

References 61 publications

Recent Advances in the DNA-Mediated Multi-Mode Analytical Methods for Biological Samples

Recent Advances in the DNA-Mediated Multi-Mode Analytical Methods for Biological Samples

Engineered aptamers for molecular imaging

Design and Application of Nuclear and Molecular Theragnostic Probes

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