Aminoacetic Acid (Glycine) as an Antifibrillary Agent in Hypothermia

SUMMARY Eighteen dogs were cooled in ice water of 5–7°C., and the frequency of spontaneous ventricular fibrillation was observed. Five dogs served as controls, nine dogs were treated with 0.5 mg persantin/min., and four dogs with 0.25 mg persantin/min. In the control group, 80% fibrillated at 19.0–20.4°C. In the group with 0.5 mg Persantin/min., 33.3% fibrillated at 16.0–17.4°C.; in the 0.25 mg persantin/min. group, 75% fibrillated at 16.2–18.1°C. The pulse rate in the groups treated with persantin showed a sudden extreme bradycardia of 5–9 beats/min. at 20.0–21.8° C., whereas this phenomenon did not occur in the control animals. The possible mode of action is briefly discussed. ZUSAMMENFASSUNG 18 Hunde wurden in Eiswasser von 5 bis 7°C unterkühlt und dabei die Häufigkeit des Auftretens von spontanem Kammerflimmern beobachtet. 5 Hunde dienten als Kontrolle, 9 Hunde wurden mit 0,5 mg Persantin pro Minute und 4 Hunde mit 0,25 mg Persantin pro Minute behandelt. 80% der Kontrolltiere zeigten Kammerflimmern, bei 19,0 bis 20,4°C. Aus der Gruppe, die 0,5 mg Persantin pro Minute erhalten hatte, flimmerten 33,3% bei 16,0 bis 17,4°C, und bei der 0,25 mg Persantin‐Gruppe flimmerten 75% bei Körpertemperaturen von 16,2 bis 18,1°C. Die Pulsfrequenz in der mit Persantin behandelten Gruppe sank bei 20,0 bis 21,8°C plötzlich ab und zeigte extreme Bradycardie von 5 bis 9 Schlägen in der Minute. Bei den Kontrolltieren war dieses Phänomen nicht zu beobachten. Der mögliche Wirkungsmechanismus wird kurz diskutiert.

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Ventricular Fibrillation in Induced Hypothermia

Caldini

1959

Postgraduate Medical Journal

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Aminoacetic Acid (Glycine) as an Antifibrillary Agent in Hypothermia

Cited by 3 publications

References 8 publications

Prevention of Fibrillation During Hypothermia by Pericardial Space Perfusion

Prevention of Fibrillation During Hypothermia by Pericardial Space Perfusion

EFFECT OF PERSANTIN® ON SPONTANEOUS VENTRICULAR FIBRILLATION IN DOGS IN DEEP HYPOTHERMIA An Experimental Study

Ventricular Fibrillation in Induced Hypothermia

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