Aminoglycoside Antibiotics

Retention of antibiotic activity against resistant bacteria harbouring aminoglycoside-N-acetyltransferase enzyme by adjuvants: a combination of in-silico and in-vitro study

“…Some members of AGAs are amikacin, gentamicin, kanamycin, neomycin, and dibekacin. Aminoglycosides inhibit bacterial protein synthesis by binding reversibly with high affinity to the 16S ribosomal RNA of the 30S ribosome 17 . This interaction with the rRNA induces codon misreading thus results in the mistranslation of proteins.…”

“…This results in the production of polypeptides containing incorrect amino acids which damage the bacterial cell membrane 18,19 . Bacterial resistance to aminoglycosides results from some combination of three mechanisms including transport alterations, ribosomal alterations, and enzymatic modifications 17 . Inactivation of aminoglycosides by aminoglycoside modifying enzymes (AMEs) is the most common and clinically significant bacterial resistance mechanism to aminoglycosides.…”