Aminoglycosides and Aminocyclitols

Dowling, Patricia M.

doi:10.1002/9781118675014.ch14

Cited by 20 publications

(21 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gentamicin is typically used against gram‐negative pathogens, with special efficacy against P. aeruginosa, which is supported by the results of this study. The reported susceptibility of gram‐positive bacteria for gentamicin is variable . Gentamicin resistance was observed in 95–100% of tested Streptococcus isolates in our study.…”

Section: Discussionmentioning

confidence: 99%

Septic keratitis in dogs, cats, and horses in Switzerland: associated bacteria and antibiotic susceptibility

Suter

Voelter

Hartnack

et al. 2017

Veterinary Ophthalmology

View full text Add to dashboard Cite

Objective To evaluate the most common bacterial pathogens associated with septic keratitis in veterinary patients from Switzerland. The second objective was to analyze antibiotic susceptibility test results of the identified bacterial pathogens. The third objective was to evaluate potential breed predispositions to septic keratitis. Procedures Two hundred and fifty-five cultures and antibiotic susceptibility reports from dogs, cats, and horses with septic keratitis that were presented to the University of Zurich Veterinary Medical Teaching Hospital between 2009 and 2013 were reviewed. Odds ratios for the risk of having a septic keratitis were estimated for all dog and cat breeds compared to the general nonbrachycephalic hospital population. Results Ninety-six, 29, and 31 positive cultures were obtained from 89 canine, 28 feline, and 29 equine eyes, respectively. Repeat sampling accounted for the differences in numbers. Negative culture results were obtained in 50, 31, and 18 cases. Staphylococci and streptococci accounted for 66% of the isolates in dogs and 80% of the isolates in cats and horses. Staphylococcus spp. had a higher percentage of fluoroquinolone-resistant isolates compared to previous reports. Brachycephalic breeds had elevated odds ratios for the presence of septic keratitis. Conclusion Identified bacterial pathogens and their prevalence as well as the elevated odds ratios for septic keratitis in brachycephalics are roughly consistent with previous studies. Based on systemic breakpoint data, resistance to commonly used topical antibiotics, including the second-generation fluoroquinolones, was found.

show abstract

Section: Discussionmentioning

confidence: 99%

Septic keratitis in dogs, cats, and horses in Switzerland: associated bacteria and antibiotic susceptibility

Suter

Voelter

Hartnack

et al. 2017

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Apramycin brought about the least pronounced and insignificant changes of ESR. We assume the reason for the less distinct changes of goat´s ESR in aminocyclitol treatment is due to the lack of nephrotoxic potential of the aminocyclitols (Dowling, 2013). Up to now they are no experimental data suggesting nephrotoxic effects after their application, even after high-dose therapy (Novak et al, 1974).…”

Section: Discussionmentioning

confidence: 98%

“…ESR values are decreased at polycythemia, leukemia and congestive heart failure. Aminoglycosides and the related in chemical structure aminocyclitols are used very often in the treatment of inflammatory diseases (Dowling, 2013). In order to minimize the adverse effects of the drugs now they are commonly used once daily in contrast with the previous treatment 2-3 times per day.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Erythrocyte Sedimentation Rate after Aminoglycoside and Aminocyclitol Treatment in Goats (Capra hircus)

Dinev¹,

Kanakov²,

Beev³

et al. 2016

İstanbul Üniv. Vet. Fak. Derg.

View full text Add to dashboard Cite

The aim of the present study was to follow up the erythrocyte sedimentation rate (ESR) in healthy female goats during and after 5-day parenteral treatment with amikacin (10 mg/kg), tobramycin (5 mg/kg), apramycin (20 mg/kg), gentamicin (4 mg/kg), kanamycin (10 mg/kg) and spectinomycin (20 mg/kg). Gentamicin and tobramycin caused an initial increase followed by a significant decrease of ESR on the 5 th day for gentamicin and the 10 th day for tobramycin, respectively, followed by recovery after the treatment. Reversely, amikacin and especially spectinomycin produced an increase of ESR without recovery several days post treatment. Kanamycin caused decrease of ESR on the 5 th day without recovery in the subsequent days. Only apramycin did not give rise to increasing of ESR. In conclusion, the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.

show abstract

“…These drugs are not absorbed after oral administration and, therefore, must be administered parentrally. [6][7][8] There are few studies with amikacin 9,10 and imipenem in chickens. Amikacin, an aminoglycoside, is potentially nephrotoxic and Figure 6.…”

Section: Discussionmentioning

confidence: 99%

Use of a Vascular Access Port for Antibiotic Administration in the Treatment of Pododermatitis in a Chicken

Doneley¹,

Smith²,

Gibson³

2015

Journal of Avian Medicine and Surgery

View full text Add to dashboard Cite

Bacterial culture and susceptibility testing results of a wound on the plantar aspect of the foot of a 4-year-old, male chicken with a class IV pododermatitis revealed a multidrug-resistant Escherichia coli bacterium, sensitive to only a few antibiotics including ceftazidime. Concerns over the volume and frequency of antibiotic injections, combined with the likely duration of treatment, led to the use of a vascular access port to facilitate intravenous antimicrobial therapy. The port was placed and maintained for 5 months without complication, and the infection was resolved. This case illustrates the feasibility and application of a vascular port in an avian patient requiring long-term intravenous therapy.

show abstract

Aminoglycosides and Aminocyclitols

Cited by 20 publications

References 108 publications

Septic keratitis in dogs, cats, and horses in Switzerland: associated bacteria and antibiotic susceptibility

Septic keratitis in dogs, cats, and horses in Switzerland: associated bacteria and antibiotic susceptibility

Comparative Study of Erythrocyte Sedimentation Rate after Aminoglycoside and Aminocyclitol Treatment in Goats (Capra hircus)

Use of a Vascular Access Port for Antibiotic Administration in the Treatment of Pododermatitis in a Chicken

Contact Info

Product

Resources

About