Aminolevulinic Acid Photodynamic Therapy in the Treatment of Erosive Pustular Dermatosis of the Scalp

Eleftheriou, Lydia I.

doi:10.1001/archdermatol.2011.299

Cited by 13 publications

(11 citation statements)

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“…3,5,27,[45][46][47][48][49] Both 5-ALA and methyl 5-ALA photodynamic therapy were shown to be effective treatments. [39][40][41][42] There were a few recurrences that were able to be retreated with an additional PDT session. The only adverse effect was a bit of irritation after the treatment that may be mitigated with the application of silicone gel wound dressings.…”

Section: Discussionmentioning

confidence: 99%

“…Photodynamic therapy (PDT) is a common alternative to steroids in the treatment of EPDS. [39][40][41][42] Patients with this therapy first receive a preprocedure curettage to remove the superficial crusting and enhance absorption of the 5-aminolevulinic acid (5-ALA), either directly or 1 to 2 weeks prior to the PDT. Fourteen patients received treatment with 20% 5-aminolevulinic acid, and one patient received methyl 5-aminolevulinic acid as part of their therapy.…”

Section: Photodynamic Therapymentioning

confidence: 99%

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Erosive pustular dermatosis of the scalp: causes and treatments

Karanfilian

Wassef

2020

Int J Dermatology

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Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the efficacy of treatments of erosive pustular dermatosis of the scalp (EPDS) is of great importance to both avoid misdiagnosis and ensure optimal treatment of this rare condition. There are numerous causes. In addition to surgeries and physical injuries, topical and procedural treatments for actinic keratoses and androgenetic alopecia can trigger the development of lesions. There are also documented associations with several autoimmune and systemic conditions. Besides corticosteroids, topical tacrolimus and photodynamic therapy were the most commonly used treatments for EPDS. They were effective with few recurrences and adverse effects. Other successful treatment options were topical dapsone, silicone gels, calcipotriol, acitretin, and isotretinoin. Oral dapsone can be used in cases of disseminated disease. Zinc sulfate should be considered with low-serum zinc levels. While cyclosporine was effective, there were adverse effects that may limit its use. It is important for dermatologists to be aware of the wide array of potential causes of erosive pustular dermatosis and include it on their differential. Additionally, although high-potency topical steroids have been historically used as the first-line treatment, there are many other effective treatments that may avoid recurrence and skin atrophy, particularly in the elderly population.

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Section: Discussionmentioning

confidence: 99%

Section: Photodynamic Therapymentioning

confidence: 99%

Erosive pustular dermatosis of the scalp: causes and treatments

Karanfilian

Wassef

2020

Int J Dermatology

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“…A number of treatments have been reported used to treat EPDS. An occasional treatment, such as photodynamic therapy, has been reported to precipitate [14,15] and to treat [41][42][43] the condition. Treatments reported have not been consistently effective or been adopted to be used as a standard.…”

Section: Treatmentmentioning

confidence: 99%

Erosive and Pustular Dermatitis of the Scalp, an Under Recognized Condition. Case Reports and Review

Drucker¹

2016

CRDOA

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Erosive pustular dermatitis of the scalp has been reported as a rare chronic and progressive inflammatory condition of the actinically damaged scalp characterized by crusts, erosions and pustules. Less than 150 cases have been reported worldwide. I present 4 representative cases, review the world literature on the condition and postulate the condition is more common than diagnosed. No single treatment has been constantly acceptable, but a review of treatments used to date can help clinicians deal with this difficult to treat chronic condition. Increased awareness of and proper diagnosis of this condition changes the approach to treatment of these patients and while giving them a better outcome, keeps the clinician vigilant of squamous cell carcinomas that can arise in this skin.

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“…Cases of EPDS with good response to PDT have been described (Cunha, Tsoukas, & Kroumpouzos, 2018;Eleftheriou, McIntee, & Stratman, 2011;Meyer, López-Navarro, Herrera-Acosta, Jose, & Herrera, 2010;Yang, Kuhn, Cohen, & Kroumpouzos, 2016), but there are also cases in which it appears as a precipitating factor of the disease (Guarneri & Vaccaro, 2009;López, López, Ramos, & Ricart, 2012). Using conventional-PDT, a photosensitizer is activated with red or blue light, being metabolized into protoporphyrin IX.…”

mentioning

confidence: 99%