Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs

Somekawa-Kondo, Tomoko; Yamaguchi, Keitaro; Ishitsuka, Yoichi; Ito, Sachiko; Tanaka, Kaori; Irikura, Mitsuru; Moriuchi, Hiroshi; Takahama, Kazuo; Ando, Yumiko; Yamazaki, Toshio; Irie, Tetsumi

doi:10.1111/j.2042-7158.2012.01566.x

Cited by 4 publications

(1 citation statement)

References 65 publications

(74 reference statements)

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“…These drugs exert a number of pharmacological effects; they antagonize asthma, relax smooth muscles, excite the CNS and cardiac muscle, influence diuresis, etc. [1][2][3]. The mechanisms underlying these effects, according to the data available, may include antagonism with respect to the adenosine receptors [4][5][6], inhibition of phosphodiesterase [7,8], acceleration of the release of intracellular calcium [9,10], competitive action on benzodiazepine receptors, and influence on GABA receptor-mediated effects [3,11,12].…”

Section: Introductionmentioning

confidence: 99%

Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons via Inhibition of Intracellular Phosphodiesterase

Yang

Ren

et al. 2015

Neurophysiology

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In acutely isolated rat primary sensory neurons, the effects of caffeine on GABA receptormediated current (I GABA ) were investigated using a whole-cell patch clamp technique. We found that applications of GABA (10-1000 µM) induced inward currents in a concentration-dependent manner; the currents manifested obvious desensitization. Pretreatment with caffeine (0.01-100 µM) suppressed I GABA in a noncompetitive manner; caffeine shifted the concentrationresponse curve for GABA downwards compared to the control. Theophylline showed a similar and stronger inhibitory effect on I GABA . Isolated application of 1 µM diazepam enhanced I GABA , while pretreatment with 10 µM caffeine and 1 µM diazepam suppressed this current. Intracellular application of the protein kinase A inhibitor H-8 dramatically weakened the inhibitory effect of caffeine on I GABA . Because primary afferent depolarization is related to GABA A receptors, our results suggest that caffeine might antagonize presynaptic inhibitory effects of primary afferents, probably via inhibition of intracellular phosphodiesterase.

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Section: Introductionmentioning

confidence: 99%

Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons via Inhibition of Intracellular Phosphodiesterase

Yang

Ren

et al. 2015

Neurophysiology

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Clinical and genetic features of acute encephalopathy in children taking theophylline

Saitoh

Shinohara

Ishii

et al. 2015

Brain and Development

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Inclusion Solves Insolubility —Translational Research Cycle from Bedside to Bench and Bench to Bedside for Drug Development Targeting Niemann-Pick Disease Type C—

Irie

2022

YAKUGAKU ZASSHI

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Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs

Abstract: Aminophylline potentially induces brain damage under hypoxic conditions. We suggest that aminophylline treatment has adverse effects in patients with hypoxaemia subsequent to respiratory disorders such as asthma.

Cited by 4 publications

References 65 publications

Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons via Inhibition of Intracellular Phosphodiesterase

Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons via Inhibition of Intracellular Phosphodiesterase

Clinical and genetic features of acute encephalopathy in children taking theophylline

Inclusion Solves Insolubility —Translational Research Cycle from Bedside to Bench and Bench to Bedside for Drug Development Targeting Niemann-Pick Disease Type C—

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