“…Due to its better bioavailability, aminophylline is oen applied to treat respiratory diseases including bronchial asthma, panting bronchitis, and cardiogenic asthma. [1][2][3][4] Based on reports, 1,2 aminiphylline is the prodrug of theophylline and would release theophylline quickly in a buffer solution (pH 7.4) and blood samples. So, the real working section of treatment is actually theophylline, while, due to the poor solubility in water, ethylenediamine is used to increase the solubility of theophylline.…”