Aminopyrroles

An Efficient Route to 2-SubstitutedN-(1-Amino-3-methylpyrrol)amides by Ring-Opening Cyclization of Benzylidene- and Alkylidenecyclopropylcarbaldehydes with Hydrazides

“…The pyrrole ring system is a useful structure in heterocyclic synthesis and displays a variety of important biological activities . Although the pyrrolamides have broad applications in medicinal chemistry, only a few synthetic methods have been developed thus far . Most of these methods relied on the Paal−Knorr condensation of 1,4-dicarbonyl compounds with hydrazine derivatives but in low yields .…”

Design of new DNA-interactive agents by molecular docking and QSPR approach

“…The polycondensed tricycles were chosen having also in mind the easiness of synthetic methodology. In fact all these compounds could be accessible from known (and already studied by us [8][9][10] ) 2-and 3-aminopyrroles, ortho-cyano substituted, and the versatile BMMAs (N-(BisMethylthio)Methylenamino Acids) according to the procedure already successfully employed in previous work 11,12 (Scheme 1). The twenty chains a-t, reported in Table 1, were selected and combined with the ring skeletons to generate the various ligands, presenting the substituents linked to the pyrrole NHs.…”

One-Pot Synthesis of 5-Methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

“…Indeed, when 2-amino-4-methyl-1H-pyrrole-3-carboxamide ( 8 ) was prepared from 6 using similar conditions, it underwent annulation with ethyl formate to 1 in about 80% yield (Scheme ). However, the yield of 8 was low, and the pyrrole was found to be unstable . Consequently, we decided to carry out the two annulation reactions in one pot.…”