Aminoquinolines afford resistance to cerebral malaria in susceptible mice

Srbljanović, Jelena; Bobić, Branko; Štajner, Tijana; Uzelac, Aleksandra; Opsenica, Igor; Jovanović, Nataša Terzić; Bauman, Neda; Šolaja, Bogdan A.; Djurković–Djaković, Olgica

doi:10.1016/j.jgar.2020.07.027

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Antimalarial Activity1

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Cited by 3 publications

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“…Among them, derivatives 3 and 6 were 5-fold more active than CQ. 30 In addition, 2 and 6 were as active as CQ and ART against the CQS 3D7 strain (2: IC 50 = 22.05 nM; 6: IC 50 = 14.02 nM). The results indicate that the length of the methylene chain affects the antiplasmodial activity.…”

Section: Antimalarial Activitymentioning

confidence: 94%

New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria

Opsenica

Selaković²,

Tot

et al. 2021

JSCS

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Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three amino-quinolines were further examined for antimalarial efficacy in a mouse model using a modified Thompson test. In this model, mice were infected with P. berghei-infected red blood cells, and drugs were administered orally. Anti-malarial 3 was found toxic at a dose of 320 (mg/kg)/day in 3/6 mice, however, 2/6 mice of the same group survived through day 31, and one of them was cured.

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Section: Antimalarial Activitymentioning

confidence: 94%