Amiodarone and the Development of ARDS After Lung Surgery

Rose, Edward; Alves, Larry E.

doi:10.1378/chest.105.6.1642

Cited by 180 publications

(71 citation statements)

References 13 publications

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“…Anesthesia, oxygen and/or mechanical ventilation may synergize APT. Surgical patients with a recent history of resection for lung cancer are at greater risk, as they have a combination of a frequent need for amiodarone to control postoperative arrhythmias, poor ventilatory reserve due to the recent lung resection, and a background of smoking, chronic obstructive pulmonary disease (COPD) or emphysema [39]. Routine use of amiodarone in this setting is discouraged.…”

Section: Clinical Patterns Of Di-ildmentioning

confidence: 99%

Interstitial Lung Disease Induced by Drugs and Radiation

Camus¹,

Fanton²,

Bonniaud³

et al. 2004

Respiration

354

273

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An ever-increasing number of drugs can reproduce variegated patterns of naturally occurring interstitial lung disease (ILD), including most forms of interstitial pneumonias, alveolar involvement and, rarely, vasculitis. Drugs in one therapeutic class may collectively produce the same pattern of involvement. A few drugs can produce more than one pattern of ILD. The diagnosis of drug-induced ILD (DI-ILD) essentially rests on the temporal association between exposure to the drug and the development of pulmonary infiltrates. The histopathological features of DI-ILD are generally consistent, rather than suggestive or specific to the drug etiology. Thus, the diagnosis of DI-ILD is mainly made by the meticulous exclusion of all other possible causes. Drug dechallenge produces measurable improvement in symptoms and imaging in the majority of patients, whereas corticosteroid therapy is indicated if symptoms are present or drug dechallenge is without an effect. Rechallenge is justified in a minority of patients, and is discouraged for diagnostic purposes only. Pneumotox^® (www.pneumotox.com) provides updated information on drug-induced respiratory disease.

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Section: Clinical Patterns Of Di-ildmentioning

confidence: 99%

Interstitial Lung Disease Induced by Drugs and Radiation

Camus¹,

Fanton²,

Bonniaud³

et al. 2004

Respiration

354

273

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“…Additionaly, AIPT is positively correlated with a cumulative dose of 140 g to 230 g [12]. In several studies pre-existing pulmonary disease was associated with higher risk of AIPT and AIPT occurred in 50% surgical survivors, and in 27% pneumonectomy patients [13][14][15].…”

Section: Case Reportmentioning

confidence: 99%

Amiodarone Induced Pulmonary Toxicity: A Fatal Case Report

Gülmez¹,

Ozsancak²

2017

J Clin Case Rep

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Amiodarone Induced Pulmonary Toxicity (AIPT) is a rare but one of the most serious adverse event that can be potentially life threatening. The incidence of AIPT is 2% to 10% and mortality rate ranges from 10% to 50% in patients who develop Acute Respiratory Distress Syndrome (ARDS). Age, preexisting lung disease, cumulative dose, thoracic surgery and pulmonary angiography are the risk factors associated with AIPT. Although there is no pathognomonic clinical, laboratory, radiographic or histological findings the diagnosis depends on clinical suspicion and exclusion of other possibilities of pulmonary disease. We present a case of 77-year-old man who presented with symptoms of pneumonia and diagnosed as AIPT by the elimination method for specific and non-specific pulmonary infection. Despite discontinuation of amiodarone and systemic therapy with corticosteroids the patient continued worsen. Pre-existing lung disease, the rapid onset of the clinical picture and the extent of lung injury on CT were the poor prognostic factors for our patient.

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“…Amiodarone is one of the preferred drugs for treating both supraventricular and ventricular arrhythmias. Due to potential development of ARDS after amiodarone in pneumonectomy [68] its use in the perioperative period has long been debated. Recent reports, however, attest to the efficacy and high safety of amiodarone in thoracic surgery.…”

Section: Postoperative Arrhythmiasmentioning

confidence: 99%