The worldwide emergence of epidemic strains of Clostridium difficile linked to increased disease severity and mortality has resulted in greater research efforts toward determining the virulence factors and pathogenesis mechanisms used by this organism to cause disease. C. difficile is an opportunist pathogen that employs many factors to infect and damage the host, often with devastating consequences. This review will focus on the role of the 2 major virulence factors, toxin A (TcdA) and toxin B (TcdB), as well as the role of other putative virulence factors, such as binary toxin, in C. difficile-mediated infection. Consideration is given to the importance of spores in both the initiation of disease and disease recurrence and also to the role that surface proteins play in host interactions.
Peritidal carbonates of the Lower Jurassic (Liassic) Gibraltar Limestone Formation, which form the main mass of the Rock of Gibraltar, are replaced by fine and medium crystalline dolomites. Replacement occurs as massive bedded or laminated dolomites in the lower 100 m of an ≈460‐m‐thick platform succession. The fine crystalline dolomite has δ18Ο values either similar to, or slightly higher than, those expected from Early Jurassic marine dolomite, and δ13C values together with 87Sr/86Sr ratios that overlap with sea‐water values for that time, indicating that the dolomitizing fluid was Early Jurassic sea water. Absence of massive evaporitic minerals and/or evaporite solution‐collapse breccias in these carbonate rocks indicates that the salinity of sea water during dolomitization was below that of gypsum precipitation. The occurrence of peritidal facies, a restricted microbiota and rare gypsum pseudomorphs are also consistent with penesaline conditions (salinity 72–199‰). The medium crystalline dolomite has some δ18Ο and δ13C values and 87Sr/86Sr ratios similar to those of Early Jurassic marine dolomites, which indicates that ambient sea water was again a likely dolomitizing fluid. However, the spread of δ18Ο, δ13C and 87Sr/86Sr values indicates that dolomitization occurred at slightly increased temperatures as a result of shallow (≈500 m) burial or that dolomitization was multistage. These data support the hypothesis that penesaline sea water can produce massive dolomitization in thick peritidal carbonates in the absence of evaporite precipitation. Taking earlier models into consideration, it appears that replacement dolomites can be produced by sea water or modified sea water with a wide range of salinities (normal, penesaline to hypersaline), provided that there is a driving mechanism for fluid migration. The Gibraltar dolomites confirm other reports of significant Early Jurassic dolomitization in the western Tethys carbonate platforms.
The Rock of Gibraltar comprises two tectonically separated limbs of an isolated klippe of Liassic Gibraltar Limestone Formation. Both limbs have similar, c. 400 m thick sequences of inner carbonate platform facies arranged in high‐frequency, metre‐scale, shallowing‐upward, peritidal cycles with emergent, caliche caps. Four cycle types are recognized on the basis of vertically repeated successions of different sedimentary structures, lithologies, facies and biota. When compared with other Liassic cycles from fault‐bound platforms of the western Mediterranean region all are found to be of similar scale, facies and cycle type. Likely common origins are through Milankovitch band allocyclicity, or autocyclic tidal flat progradation superimposed on regional subsidence. Within the Gibraltar Limestone high‐frequency cycles are superimposed on a low‐frequency (third order?) cyclicity that is revealed, through the use of Fischer plots, to control the occurrrence of facies, biota, high‐frequency cycle types and dolomitization. Falling sea‐level and lowstand phases, with reduced accommodation space, are typified by restricted, inner platform facies and cycles and by early reflux dolomitization. Transgressive and highstand phases, with more accommodation space, are characterized by the absence of early dolomites, the incoming of inner platform microfossils (i.e. foraminifera and calcareous algae) and by less restricted marine facies (i.e. oncoids, shelly rudstones, packstones and grainstones). Fischer plots have demonstrable value in the correlation and analysis of tectonically separated and geographically isolated cyclic sequences that lack prominent marker beds or stratigraphically useful biotas.
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