Amiodarone in Testis and Semen

Adams, Philip C.; Holt, P.; Holt, David W.

doi:10.1016/s0140-6736(85)91111-0

Cited by 16 publications

(9 citation statements)

References 1 publication

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“…This is consistent with the observation that the reduction or discontinuation of amiodarone could alleviate or cure the epididymitis, including the pain [2,6]. It has been shown that the concentrations of amiodarone in the testicular tissue can be 25-3,000 times higher than in the plasma [7]. Due to its high lipophilicity and long elimination half-life, the drug and its major metabolite desethylamiodarone can accumulate extensively in adipose tissue and in organs such as the testis.…”

Section: Discussionsupporting

confidence: 88%

Amiodarone-Induced Epididymitis: A Pathologically Confirmed Case Report and Review of the Literature

Liu

Cheng

et al. 2014

Cardiology

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We report a case of amiodarone-induced epididymitis and review the pertinent literature. This disease is currently a diagnosis of exclusion and is believed to be self-limiting. We found new evidence for the pathological diagnosis and identified amiodarone-like crystals in the epididymis as a pathological mechanism of this disease. This case also suggests that amiodarone-induced epididymitis is not self-limiting. Continued use of amiodarone according to the current guidelines led to a bilateral epididymectomy. We recommend withdrawal or reduction of amiodarone dosage immediately once the signs and symptoms of epididymitis present in this population of patients. When epididymitis does not seem to be caused by an infection or any other identifiable etiology, this should not be overlooked by the cardiologist, urologist or general practitioner. These findings and recommendations should help reduce the suffering of patients and improve their clinical outcomes.

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Section: Discussionsupporting

confidence: 88%

Amiodarone-Induced Epididymitis: A Pathologically Confirmed Case Report and Review of the Literature

Liu

Cheng

et al. 2014

Cardiology

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“…Amiodarone accumulates in several tissues including the testes, where drug levels may be 50 times higher than in any other tissue [8,9]. Gasprich et al [3] reported an 11 % incidence of epididy mitis related to amiodarone therapy.…”

Section: Case Reports Discussionmentioning

confidence: 99%

Amiodarone-lnduced Epididymitis

Hamoud¹,

Kaneti²,

Smailowitz³

et al. 1996

Eur Urol

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“…36,37 Although the exact mechanism of this disease is unknown, studies have shown the drug concentration to be 25 to 3000 times higher in the testis than in plasma. 38 Reduction or discontinuation of amiodarone provides rapid relief of symptoms, although symptoms have been reported to recur if the drug is reinstituted at the same dosage. 39 Ultrasound findings demonstrate enlargement of the epididymis and hyperemia, which should be differentiated from infectious epididymitis by history.…”

Section: Drug-induced Epididymitis (Chemical Epididymitis)mentioning

confidence: 99%

Imaging of the Epididymis

Lee

Bhatt

Dogra

2008

Ultrasound Quarterly

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Ultrasonography performed with a high-frequency transducer is the modality of choice for evaluating acute and nonacute scrotal disease. Acute epididymitis and epididymo-orchitis are the most common conditions that present with acute scrotal pain. Differentiation of these from testicular torsion is important for determining the appropriate management. High-transducer sonography allows the visualization of the epididymis and its detailed anatomy. We present important sonographic features of epididymitis and epididymo-orchitis caused by infectious and noninfectious etiologies. Features of benign and malignant epididymal lesions, including epididymal cysts, spermatoceles and tubular ectasia, sperm granulomas, adenomatoid tumors, leiomyomas, papillary cyst adenomas, lymphoma, and metastases are also presented. In addition, epididymal trauma and torsion are discussed. The goal of the review is to provide the radiologist with a better understanding of the numerous pathological conditions that occur in the epididymis.

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Amiodarone in Testis and Semen

Cited by 16 publications

References 1 publication

Amiodarone-Induced Epididymitis: A Pathologically Confirmed Case Report and Review of the Literature

Amiodarone-Induced Epididymitis: A Pathologically Confirmed Case Report and Review of the Literature

Amiodarone-lnduced Epididymitis

Imaging of the Epididymis

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