Amiodarone prophylaxis for tachycardias after coronary artery surgery: a randomised, double blind, placebo controlled trial.

Butler, John M.; Harriss, D.R.; Sinclair, Michael C.; Westaby, Stephen

doi:10.1136/hrt.70.1.56

Cited by 122 publications

(51 citation statements)

References 27 publications

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“…Redle et al 79 reported a nonsignificant, modest reduction in postoperative AF in a study of 127 patients after CABG surgery receiving oral amiodarone beginning 1 to 3 days before surgery. In a study of 120 patients, Butler et al 80 reported a significant reduction in postoperative AF with amiodarone. Hohnloser et al 81 observed a significant reduction in postoperative AF (from 21% to 5%, PϽ0.05) with intravenous amiodarone started postoperatively.…”

Section: Amiodarone For Afmentioning

confidence: 99%

Evidence-Based Analysis of Amiodarone Efficacy and Safety

1999

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Section: Amiodarone For Afmentioning

confidence: 99%

Evidence-Based Analysis of Amiodarone Efficacy and Safety

1999

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“…There were 9 trials [42][43][44][45][46][47][48][49][50] that evaluated the use of amiodarone, including 1384 patients (Figure 3). Individual study size ranged from 77 to 300 46,47 patients.…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

“…The incidence of postoperative stroke was available for 14 of 52 trials. 9,13,28,33,37,[41][42][43][44][45][46]48,54,59 These trials represented data for 2877 of a total of 8122 patients randomized (35%). In these studies, the percentage of patients with AF was reduced from 38.6% in the control group to 23.7% in the treatment group (OR, 0.38; 95% CI, 0.28 to 0.52), which is similar to the overall estimate.…”

Section: Postoperative Af and Risk Of Strokementioning

confidence: 99%

Interventions on Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Heart Surgery

et al. 2002

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Background-Postoperative atrial fibrillation (AF) is a common complication of cardiac surgery and has been associated with increased incidence of other complications and increased hospital length of stay (LOS). Prevention of AF is a reasonable clinical goal, and, consequently, many randomized trials have evaluated the effectiveness of pharmacological and nonpharmacological interventions for prevention of AF. To better understand the role of various prophylactic therapies against postoperative AF, a systematic review of evidence from randomized trials was performed. Methods and Results-Fifty-two randomized trials (controlled by placebo or routine treatment) of ␤-blockers, sotalol, amiodarone, or pacing were identified by systematic literature search.

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“…Thus, a reduction by 22.5% to 37% was reported for amiodarone, as compared with placebo in the prevention of AF 41 . Despite showing a reduction in POAF incidence, Butler et al 53 reported the presence of bradiarrhythmias and pauses as complications of this therapy and limitations for its routine administration.…”

Section: Amiodaronementioning

confidence: 99%

Fibrilação atrial no pós-operatório de cirurgia cardíaca

Ferro¹,

Oliveira²,

Nunes³

et al. 2009

Arq. Bras. Cardiol.

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SummaryAtrial fibrillation (AF) is an arrhythmia frequently seen in the postoperative period of cardiac surgery. In this context, it is associated with the presence of comorbidities, longer length of hospital stay, and higher costs related to surgery.The mechanisms involved in the genesis of AF in the postoperative period of cardiac surgery (AFPO) are different from those causing paroxysmal AF. Knowledge of these mechanisms permits the use of efficient measures to reduce the incidence of this arrhythmia.According to recommendations of the literature, treatment is efficient and safe, because the rates of reversion to sinus rhythm are high and complications are reduced, and it is not associated with a high frequency of side effects.

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Amiodarone prophylaxis for tachycardias after coronary artery surgery: a randomised, double blind, placebo controlled trial.

Cited by 122 publications

References 27 publications

Evidence-Based Analysis of Amiodarone Efficacy and Safety

Evidence-Based Analysis of Amiodarone Efficacy and Safety

Interventions on Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Heart Surgery

Fibrilação atrial no pós-operatório de cirurgia cardíaca

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