Amnesia following infarction in the right retrosplenial region

Yasuda, Yuzuru; Watanabe, Toshiyuki; Tanaka, Hisataka; Ino, Tadashi; Akiguchi, Ichiro

doi:10.1016/s0303-8467(97)80005-4

Cited by 32 publications

(17 citation statements)

References 19 publications

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“…This possible role of the PCC in topographical memory is consistent with the results of the lesion studies in animals (Markowska, Olton, Murray, & Gaffan, 1989;Murray, Davidson, Gaffan, Olton, & Suomi, 1989;Sutherland, Whishaw, & Kolb, 1988), and those of functional imaging studies on topographic navigation (Burgess, Maguire, Spiers, & O'Keefe, 2001;Mellet et al, 2000;Ghaem et al, 1997;Maguire, Frackowiak, & Frith, 1997). In contrast to the view of a space-specific role of the PCC, however, a role in episodic retrieval in general has been suggested for this region by previous neuropsychological reports (Maeshima et al, 2001;Yasuda, Watanabe, Tanaka, Tadashi, & Akiguchi, 1997;Valenstein et al, 1987) and functional imaging studies (e.g., Henson, Rugg, Shallice, Josephs, & Dolan, 1999;Wiggs, Weisberg, & Martin, 1999;Buckner, Raichle, Miezin, & Petersen, 1996;Tulving, Markowitsch, Craik, Habib, & Houle, 1996). In particular, activation in the PCC during presentation of personally familiar faces and voices compared with that of unfamiliar ones ) is relevant to this study.…”

Section: Introductionsupporting

confidence: 89%

“…Inhomogeneous neuropsychological deficits reported for patients with posterior cingulate lesions, for example, selective topographic memory deficits (Takahashi et al, 1997;Cammalleri et al, 1996) or all-encompassing amnesia (Maeshima et al, 2001;Yasuda et al, 1997;Valenstein et al, 1987), suggest the existence of multiple functional subdivisions in this cortex. In monkeys, neurons involved in monitoring of eye movement were found in the cortex on the surface of the cingulate gyrus superior to the splenium (Olson, Musil, & Goldberg, 1996), but those related to sensorytriggered and self-paced forelimb movement were found in the cortex buried in the cingulate sulcus (Shima et al, 1991); the two areas where these different populations of neurons were found seem to be anatomically discrete (Vogt, Finch, et al, 1992).…”

Section: Functional Subdivisions Of the Pccmentioning

confidence: 99%

“…Results of a few studies presenting relatively reliable retrosplenial activation indicate that activation in this area is related to episodic memory retrieval Wiggs et al, 1999). Previous case reports suggest that a lesion confined to the retrosplenial cortex can cause amnesia (Yasuda et al, 1997;Valenstein et al, 1987). It thus appears that the retrosplenial cortex is involved in episodic memory retrieval, although its precise role remains to be further elucidated.…”

Section: No Significant Activationmentioning

confidence: 99%

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Cortical Representations of Personally Familiar Objects and Places: Functional Organization of the Human Posterior Cingulate Cortex

Sugiura

Shah

Zilles

et al. 2005

Journal of Cognitive Neuroscience

160

106

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The recognition of both personally familiar objects and places involves nonspatial memory retrieval processes, but only personally familiar places are represented as space. Although the posterior cingulate cortex (PCC) is considered to process both types of such memories, its functional organization is poorly understood. In this event-related fMRI study, normal subjects judged familiar/unfamiliar pictures in four categories: familiar places (FP), familiar objects (FO), unfamiliar places (UP), and unfamiliar objects (UO), thus constituting a two-factorial design. A significant main effect of stimuli with greater activation in the place (FP and UP) than object (FO and UO) trials was observed bilaterally in several medial temporo-occipito-parietal regions, including the caudal PCC (cPCC) and parahippocampal gyrus. The reverse comparison revealed greater activation in the lateral inferior occipito-temporal junctions and intraparietal sulci bilaterally. A significant main effect of familiarity with greater activation in the familiar (FP and FO) than unfamiliar (UP and UO) trials was observed in the mid-dorsal PCC (mPCC), retrosplenial cortex, posterior precuneus, and the left intraparietal sulcus. Activation specific to the FP trials (as assessed by the interaction) was observed in the right posterodorsal PCC (pPCC) only. Together with data from previous functional imaging studies, the results suggest a functional segregation of human PCC with differential involvement of pPCC in spatial representations of personally familiar places and of the mPCC and retrosplenial cortex in episodic retrieval of personally familiar places and objects. Activation of the left intraparietal sulcus may reflect retrieval of memories related to object manipulation.

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Section: Introductionsupporting

confidence: 89%

Section: Functional Subdivisions Of the Pccmentioning

confidence: 99%

Section: No Significant Activationmentioning

confidence: 99%

See 1 more Smart Citation

Cortical Representations of Personally Familiar Objects and Places: Functional Organization of the Human Posterior Cingulate Cortex

Sugiura

Shah

Zilles

et al. 2005

Journal of Cognitive Neuroscience

160

106

View full text Add to dashboard Cite

show abstract

“…Concerning clinical evidence, it has been suggested that right retrosplenial lesions lead to pure topographical disorientations (Valenstein et al, 1987; Yasuda et al, 1997; Aguirre and D'Esposito, 1999; Maguire, 2001; Vann and Aggleton, 2004; Vann et al, 2009), reflecting a type of heading disorientation (i.e., an inability to represent the orientation direction with respect to the external environment).…”

Section: Discussionmentioning

confidence: 99%

Differential hippocampal and retrosplenial involvement in egocentric-updating, rotation, and allocentric processing during online spatial encoding: an fMRI study

Gomez

Cerles

Rousset

et al. 2014

Front. Hum. Neurosci.

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The way new spatial information is encoded seems to be crucial in disentangling the role of decisive regions within the spatial memory network (i.e., hippocampus, parahippocampal, parietal, retrosplenial,…). Several data sources converge to suggest that the hippocampus is not always involved or indeed necessary for allocentric processing. Hippocampal involvement in spatial coding could reflect the integration of new information generated by “online” self-related changes. In this fMRI study, the participants started by encoding several object locations in a virtual reality environment and then performed a pointing task. Allocentric encoding was maximized by using a survey perspective and an object-to-object pointing task. Two egocentric encoding conditions were used, involving self-related changes processed under a first-person perspective and implicating a self-to-object pointing task. The Egocentric-updating condition involved navigation whereas the Egocentric with rotation only condition involved orientation changes only. Conjunction analysis of spatial encoding conditions revealed a wide activation of the occipito-parieto-frontal network and several medio-temporal structures. Interestingly, only the cuneal areas were significantly more recruited by the allocentric encoding in comparison to other spatial conditions. Moreover, the enhancement of hippocampal activation was found during Egocentric-updating encoding whereas the retrosplenial activation was observed during the Egocentric with rotation only condition. Hence, in some circumstances, hippocampal and retrosplenial structures—known for being involved in allocentric environmental coding—demonstrate preferential involvement in the egocentric coding of space. These results indicate that the raw differentiation between allocentric versus egocentric representation seems to no longer be sufficient in understanding the complexity of the mechanisms involved during spatial encoding.

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“…It has long been appreciated that the retrosplenial cortex has dense, reciprocal connections with both the anterior thalamic nuclei and hippocampal formation. Neuropsychological studies of amnesia have also shown that damage to this area can cause anterograde amnesia (Maguire, 2001b;Rudge & Warrington, 1991;Valenstein et al, 1987;Yasuda, Watanabe, Tanaka, Tadashi, & Akiguchi, 1997) and topographical amnesia (Maguire, 2001b;Yasuda et al, 1997). Furthermore, functional neuroimaging studies repeatedly find raised retrosplenial activity during a range of memory (Cabeza & Nyberg, 2000;Maddock, Garrett, & Buonocore, 2001;Maguire, 2001aMaguire, , 2001b and spatial navigation (Epstein, Parker, & Feiler, 2007;Iaria, Chen, Guariglia, Ptito, & Petrides, 2007) tasks.…”

Section: Covert Pathology Amnesia and The Retrosplenial Cortexmentioning

confidence: 99%

EPS Mid-Career Award 2006: Understanding anterograde amnesia: Disconnections and hidden lesions

Aggleton

2008

Quarterly Journal of Experimental Psychology

108

103

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Three emerging strands of evidence are helping to resolve the causes of the anterograde amnesia associated with damage to the diencephalon. First, new anatomical studies have refined our understanding of the links between diencephalic and temporal brain regions associated with amnesia. These studies direct attention to the limited numbers of routes linking the two regions. Second, neuropsychological studies of patients with colloid cysts confirm the importance of at least one of these routes, the fornix, for episodic memory. By combining these anatomical and neuropsychological data strong evidence emerges for the view that damage to hippocampal-mammillary body-anterior thalamic interactions is sufficient to induce amnesia. A third development is the possibility that the retrosplenial cortex provides an integrating link in this functional system. Furthermore, recent evidence indicates that the retrosplenial cortex may suffer "covert" pathology (i.e., it is functionally lesioned) following damage to the anterior thalamic nuclei or hippocampus. This shared indirect "lesion" effect on the retrosplenial cortex not only broadens our concept of the neural basis of amnesia but may also help to explain the many similarities between temporal lobe and diencephalic amnesia.

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Amnesia following infarction in the right retrosplenial region

Cited by 32 publications

References 19 publications

Cortical Representations of Personally Familiar Objects and Places: Functional Organization of the Human Posterior Cingulate Cortex

Cortical Representations of Personally Familiar Objects and Places: Functional Organization of the Human Posterior Cingulate Cortex

Differential hippocampal and retrosplenial involvement in egocentric-updating, rotation, and allocentric processing during online spatial encoding: an fMRI study

EPS Mid-Career Award 2006: Understanding anterograde amnesia: Disconnections and hidden lesions

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