Amniotic fluid induces platelet-neutrophil aggregation and neutrophil activation

Chen, Kuen‐Bao; Chang, Shih‐Sheng; Tseng, Yu Lun; Chiu, Te-Fa; Liao, Cheng Chun; Ho, Ming‐Chih; Huang, Go Shine; Li, Chi Yuan

doi:10.1016/j.ajog.2013.01.012

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…Amniotic fluid or fetal components may trigger complement activation or an atypical immune reaction, which may be the initial step in the development of PAM by inflammatory cell infiltration and anaphylactoid reaction due to mast cells. As a result, the production of large amounts of histamine, bradykinin, inflammatory cytokines such as interleukin‐8, and procoagulant substances can lead to endothelial activation and a massive inflammatory reaction . After all, uterine muscles relax and become edematous, leading to a loss of synchronized contraction of the myometrium.…”

Section: Pathological Examination Of Lung and Uterus In Afementioning

confidence: 99%

Amniotic fluid embolism: Pathophysiology from the perspective of pathology

Tamura

Farhana

Oda

et al. 2017

J of Obstet and Gynaecol

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Amniotic fluid embolism (AFE) is recognized as a type of syndrome characterized by the abrupt onset of hypoxia, hypotension, seizures, or disseminated intravascular coagulopathy (DIC), occurring during labor, delivery, or immediately postpartum, caused by the inflow of amniotic components into the maternal circulation. AFE is a rare condition but one of the most serious obstetrical complications, resulting in a high mortality rate among pregnant women. Despite earlier recognition and intensive critical management, we often encounter patients who unfortunately do not recover from the exacerbation of AFE-related conditions. A major concern is that there are no effective evidence-based therapies for AFE, because its pathophysiology is still not well understood. This article reviewed AFE, focusing on the pathology and currently proposed pathophysiology.

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Section: Pathological Examination Of Lung and Uterus In Afementioning

confidence: 99%

Amniotic fluid embolism: Pathophysiology from the perspective of pathology

Tamura

Farhana

Oda

et al. 2017

J of Obstet and Gynaecol

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“…C1INH not only decreases the activity of C1 esterase, but has also been shown to inhibit factor XIIa, XIa, and kallikrein activities, which also appear to participate in the pathogenesis of AFE. Furthermore, Chen et al [20] described how amniotic fluid was able to induce inflammation via neutrophil activation and platelet neutrophil aggregation. It remains unknown, however, what renders an individual susceptible to this 'anaphylactic shock' [21].…”

Section: Pathogenesis and Pathophysiologymentioning

confidence: 98%

Amniotic fluid embolism

Balinger¹,

Lam

Hon³

et al. 2015

Current Opinion in Obstetrics &Amp; Gynecology

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Although AFE cannot be prevented, early diagnosis and intervention may lead to better outcomes for both the mother and the fetus. Clinical suspicion, traditional laboratory data, or intravascular cellular debris (demonstrated only in 50% of patients) are insufficient to make a definitive diagnosis of AFE. An evolving array of novel biomarkers may help differentiate AFE from other conditions, but none of them currently provide sufficient 'early warning' ability to make real-time impact on diagnosis and/or treatment of AFE.

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“…If the composition of amniotic fluid determines this reaction, this might explain why women carrying a male fetus tend to be more frequently affected in our study. Apart from insoluble fetal components in amniotic fluid, which also contains soluble substances such as bradykinin, histamine, and procoagulant, can lead to endothelial activation and a massive inflammatory reaction [11]. Another pathophysiological mechanism may be complement activation triggering AFE [12].…”

Section: Arch Gynecol Obstetmentioning

confidence: 98%

From appearance to essence: 10 years review of atypical amniotic fluid embolism

Shen

Wang

Yang

et al. 2015

Arch Gynecol Obstet

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Staying alert to premonitory symptoms of AFE is critical to turn it to a remediable disease. Patient complaints such as breathlessness, chest pain, feeling cold, distress, panic, a feeling of nausea, and vomiting should elicit close attention. The management of a suspected episode of amniotic fluid embolism is generally considered to be supportive. Hysterectomy must be performed if there is further progression of symptoms. Due to advances in acute care, mortality has decreased in recent years, highlighting the importance of early detection and treatment.

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Amniotic fluid induces platelet-neutrophil aggregation and neutrophil activation

Cited by 9 publications

References 38 publications

Amniotic fluid embolism: Pathophysiology from the perspective of pathology

Amniotic fluid embolism: Pathophysiology from the perspective of pathology

Amniotic fluid embolism

From appearance to essence: 10 years review of atypical amniotic fluid embolism

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