Amniotic Fluid Matrix Metalloproteinase-9 and Interleukin-6 in Predicting Intra-Amniotic Infection

Harirah, Hassan; Donia, Sahar E.; Hsu, Chaur‐Dong

doi:10.1097/00006250-200201000-00016

Cited by 27 publications

(36 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Significantly different from delivery at term and post date pregnancy. 7 Significantly different from perinatal period and post date pregnancy. 8 Significantly different from delivery at term.…”

Section: Sialylationmentioning

confidence: 93%

Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age

et al. 2005

View full text Add to dashboard Cite

The present knowledge concerning the glycan structures and role of glycoconjugates derived from amniotic fluid is fragmentary and mainly focuses on the individual glycoproteins. The question has arisen as whether the general glycosylation pattern of amniotic fluid glycoconjugates can change with the progression of a normal pregnancy. In the present work we have described the dynamic, quantitative alterations in relative amounts of sialic acid and fucose linked by a variety of anomeric linkages to subterminal oligosaccharide structures of amniotic fluid glycoconjugates in relation to pregnancy age. The analysis was performed in the following groups of amniotic fluids derived from normal pregnancy by lectin dotting method: "2nd trimester" (14-19 weeks), "3rd trimester" (29-37 weeks), "perinatal period" (38-40 weeks) , "delivery at term" (39-41 weeks) and "post date pregnancy" (41-43 weeks). In the "3rd trimester" the amniotic fluid glycoconjugates contained higher relative amounts of glycans terminated by alpha2-6-linked sialic acid (p < 0.00002) and by alpha1-6 innermost fucose (p < 0.000001) than those in the 2nd trimester. In contrast, they showed the lower relative amount of fucose linked alpha1-3 (p < 0.02). At the perinatal period the relative amount of alpha2-6-linked sialic acid increased (p < 0.03), and it then decreased during delivery (p < 0.02) to the level found in the "3rd trimester" group. In the post date pregnancy all parameters studied increased. The sialyl- and fucosyl-glycotopes of the amniotic fluid glycoconjugates may play an critical role in growth and tissue remodeling of the foetus, as well as may might reflect maturation of a foetus. Additionally, a determination of the glycotope expressions might be helpful in prenatal diagnosis as predictor factors for well being of mother and child.

show abstract

Section: Sialylationmentioning

confidence: 93%

Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age

et al. 2005

View full text Add to dashboard Cite

show abstract

“…This characteristic may be due to the fact that MMP-8 is produced mainly by activated neutrophils and is therefore an index of the fetal inflammatory response syndrome [76]. MMP-9 also seems to be important, since its increase follows chorion decidual bacterial invasion and is associated with a decrease in TIMP and onset of labor [77,78]. An increase in metalloproteinases depends at least in part on reactive oxygen species [79].…”

Section: The Metalloproteinasesmentioning

confidence: 99%

“…A high vaginal IL-8 concentration, increased neutrophils, abnormal vaginal gram stain, absence of hydrogen peroxide with bacteria and anaerobic vaginal flora have been observed in cases of amniotic fluid infection [168]. Determination of MMP-8 in amniotic fluid has also been suggested as a reliable marker of intrauterine infection and risk of premature delivery [78]. Increased serum procalcitonin levels have been observed in babies of mothers with CA [169].…”

Section: Diagnosis and Prevention Of Camentioning

confidence: 99%

Chorioamnionitis: A Risk Factor for Fetal and Neonatal Morbidity

Bracci¹,

Buonocore²

2003

Neonatology

113

View full text Add to dashboard Cite

Despite widespread use of drugs to arrest preterm labor, there has been no decrease in the numbers of low-birth-weight or preterm infants in the last 20 years. Evidence from many sources links preterm birth to symptomatic and subclinical infections. Recently, an increasing body of evidence has suggested that not only is subclinical infection responsible for preterm birth but also for many serious neonatal sequelae, including periventricular leukomalacia, cerebral palsy, respiratory distress and even bronchopulmonary dysplasia and necrotizing enterocolitis. Proxies of intrauterine infection include clinical chorioamnionitis, histological chorioamnionitis and intraamniotic increase in cytokines, which have been found to be associated with acute neonatal morbidity and mortality and, at least to some degree, with neurological impairment, chronic lung disease and thymus involution in the preterm infant. The infectious/inflammatory mechanisms involved are not fully understood, and the types of microbes and genetic features of host adaptive and innate immune responses need to be better characterized.

show abstract

“…While the researchers have shown that IL-1 type I receptor knockout mice also show premature birth after exposure to infection. Chorioamnionitis involves the dominance of interleukin-6 in decidual cells [45][46]. Often intrauterine infection is asymptomatic and ISSN: 2320-5407 Int.…”

Section: Intrauterine Infections Trigger Inflammatory Responses:-mentioning

confidence: 99%

Protein Kinase C – Zeta Inhibitors: A New Hope for Controlling Maternal Intrauterine Infection Induced Premature Birth.

Kumar¹,

Hussain²,

Singh³

et al. 2017

IJAR

View full text Add to dashboard Cite

Amniotic Fluid Matrix Metalloproteinase-9 and Interleukin-6 in Predicting Intra-Amniotic Infection

Cited by 27 publications

References 13 publications

Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age

Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age

Chorioamnionitis: A Risk Factor for Fetal and Neonatal Morbidity

Protein Kinase C – Zeta Inhibitors: A New Hope for Controlling Maternal Intrauterine Infection Induced Premature Birth.

Contact Info

Product

Resources

About