2020
DOI: 10.1155/2020/4238919
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Amniotic Membrane as a Main Component in Treatments Supporting Healing and Patch Grafts in Corneal Melting and Perforations

Abstract: Purpose. To report on surgical approaches using amniotic membrane applications and patch grafts in corneal melting and perforations. Anatomical and functional results, including advantages and disadvantages of the interventions, will also be explored. Methods. A five-year retrospective analysis of 189 surgical treatments involving corneal melting with perforation was performed. In one evaluated treatment type, a graft of amniotic membrane, often folded one to three times, was sutured with the epithelial side f… Show more

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Cited by 20 publications
(24 citation statements)
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References 27 publications
(56 reference statements)
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“…In the patch or overlay technique, the AM is placed temporarily on the ocular surface, acting as biological bandage, but not being integrated into the host. In this case, the epithelium is expected to grow underneath rather than over the top, and the AM will disassociate from the ocular surface after a certain time [ 32 ]. Regardless the surgical technique employed, topical antibiotic application is required in order to eliminate the risk of infectious keratitis.…”
Section: Discussionmentioning
confidence: 99%
“…In the patch or overlay technique, the AM is placed temporarily on the ocular surface, acting as biological bandage, but not being integrated into the host. In this case, the epithelium is expected to grow underneath rather than over the top, and the AM will disassociate from the ocular surface after a certain time [ 32 ]. Regardless the surgical technique employed, topical antibiotic application is required in order to eliminate the risk of infectious keratitis.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, it may be difficult to fold and stabilize the slippery layers of the AM. 5 Tectonic full thickness or lamellar corneal graft is an alternative option. Nonetheless, irregular astigmatism 7 in this patient's only eye as well as risk of graft rejection and suture-related complications were a concern in our case, in particular because he had learning difficulty with a history of eye rubbing.…”
Section: Discussionmentioning
confidence: 99%
“…Corneal wound burn is an uncommon complication of phacoemulsification surgery 1 that can result in further complications including high astigmatism, 2 corneal edema, and wound leak, 2 and endophthalmitis. 3 Several methods of treating corneal deficit and persistent wound leak have been described in the literature including cyanoacrylate or fibrin glue, 4 amniotic membrane (AM) patch graft, 5 ethanol or glycerol preserved corneal patch graft, 6 tectonic full thickness or lamellar corneal graft, 7 and conjunctival flap. 8 This case documents a previously unreported use of Tutoplast ® (Innovative Ophthalmic Products, Inc., Costa Mesa, CA, USA) human pericardium patch graft in managing persistent wound leak and corneal gaping wound after phacoemulsification and lens implant surgery.…”
Section: Introductionmentioning
confidence: 99%
“…In one case, debridement was performed for redundant or loose epithelial margins. Additional surgical procedures were not needed in our cohort of patients (11,12).…”
Section: Surgical Techniquementioning
confidence: 99%