Amniotic Membrane for Ocular Surface Reconstruction: Donor Variations and the Effect of Handling on TGF-β Content

Hopkinson, Andrew; McIntosh, Richard S.; Tighe, Patrick J.; James, David; Dua, Harminder S.

doi:10.1167/iovs.05-1415

Cited by 129 publications

(110 citation statements)

References 36 publications

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“…However, there was a reduction in acute pain and more rapid epithelisation in moderate burns. 43,44 No benefit was confered in severe burns. No difference was found in the treatment of neurotrophic ulcers compared with conventional therapies.…”

Section: Limitations Of Ammentioning

confidence: 99%

“…Further variations exist dependent on the foetal sex, health, gestational age, and specifics relating to labour. Hopkinson et al 44 showed the relationship of handling and processing of AM on the possible eventual alterations in the final make of the AM with regard to TGFb. Similar variations have been reported by Gicquel et al 47 with regard to epidermal growth factor.…”

Section: Limitations Of Ammentioning

confidence: 99%

See 1 more Smart Citation

Amniotic membrane in ophthalmology: indications and limitations

Rahman

Said

Maharajan

et al. 2009

Eye

156

108

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The amniotic membrane remains a useful tool in the treatment of several ophthalmic conditions, especially those related to the ocular surface. However, the 'success' reported in individual case reports and case series is not substantiated in the few published randomised controlled trials. More often than not, it is not as good as existing alternative options and, at best, is as good but with probably an increased cost. The variable outcomes could be related to inter and intra donor variations in the membrane and the depletion or alterations in its constituents subsequent to processing and storage. The membrane thus is a fairly 'non-standardised product' making comparisons of different applications and indications difficult. The potential for 'epidemic' infections, such as HIV, hepatitis B and C, is a serious issue as, in many parts of the world, fresh unquarantined membrane, at times with no tests for the above infectious agents, is being used. The exact mechanism of action of the membrane is not known but the consensus is that it acts as a substrate or scaffold for host cells to populate and thus facilitate healing and repair. The development of a standard 'synthetic membrane' using collagen or polymer matrices impregnated with putative beneficial ingredients, such as growth factors and antimicrobials, is being considered and may prove to be a step in the right direction.

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Section: Limitations Of Ammentioning

confidence: 99%

Section: Limitations Of Ammentioning

confidence: 99%

Amniotic membrane in ophthalmology: indications and limitations

Rahman

Said

Maharajan

et al. 2009

Eye

156

108

View full text Add to dashboard Cite

show abstract

“…[32][33][34][35][36] However, the high inter-and intra-tissue variability in morphological, chemical, and optical properties limit the use of the human amniotic membrane in clinical settings. [37][38][39] Alternatively, human donor corneal stromal tissues have been proposed as substrates for human corneal epithelium growth, displaying, in vitro, features similar to the native limbal epithelium. 40 The lack of corneal tissue donor availability significantly affects its clinical potential for corneal reconstruction.…”

Section: Corneal Epitheliummentioning

confidence: 99%

Corneal Tissue Engineering: Recent Advances and Future Perspectives

Ghezzi

Rnjak‐Kovacina

Kaplan

2015

Tissue Engineering Part B: Reviews

167

151

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“…AM is generally rendered non-viable during preservation, either by drying or freezing. [29] As a non-viable tissue, currently used surgically, AM is an ideal candidate for terminal sterilization.…”

Section: Challenges Of Tbtm Manufacturing and Risk Of Contaminationmentioning

confidence: 99%

Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

Marsit

Sidney

Branch

et al. 2016

Plasma Processes & Polymers

Self Cite

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Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron‐beam, and ethylene oxide protocols are well‐established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non‐thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP.

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Amniotic Membrane for Ocular Surface Reconstruction: Donor Variations and the Effect of Handling on TGF-β Content

Cited by 129 publications

References 36 publications

Amniotic membrane in ophthalmology: indications and limitations

Amniotic membrane in ophthalmology: indications and limitations

Corneal Tissue Engineering: Recent Advances and Future Perspectives

Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

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