Amniotic membrane use in ophthalmology

Gomes, José Álvaro Pereira; Romanò, A; Santos, Myrna Serapião dos; Dua, Harminder S.

doi:10.1097/01.icu.0000172827.31985.3a

Cited by 177 publications

(128 citation statements)

References 50 publications

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“…2 Ma et al 25 have found that single-layered amniotic membrane was able to reduce the recurrence to 12.5%, which was comparable with our study. They stated that the addition of mitomycin C did not further reduce the recurrence rate.…”

Section: Discussionsupporting

confidence: 82%

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Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

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Purpose To compare the results of amniotic membrane transplantation (AMT) using fibrin glue vs vicryl sutures in pterygium surgery. Methods We carried out a prospective, randomised clinical study of 70 eyes (70 patients) with primary pterygium. After the removal of pterygium, patients were randomised to undergo AMT using fibrin glue (Tisseel, 32 eyes) or 8-0 vicryl sutures (38 eyes). Clinical examination and digital photographing were performed at each visit and the patients were followed up for at least 12 months. Post-operative symptoms in the first month were evaluated according to a fivepoint scale. Final appearances were graded from 1 to 4 in which grade 4 represented true (corneal) recurrence and grade 3 indicated conjunctival recurrence. Results The average operation time in the fibrin glue and suture groups were 11.2 ± 2.4 min (mean ± SD) and 18.7 ± 2.2 min, respectively (P ¼ 0.018). Significantly fewer post-operative symptoms were observed in the fibrin glue group at post-operative days 1, 7, and 14 (Po0.05 for all). At the end of the follow-up, true recurrence (grade 4) was developed in three eyes (9.4%) in the fibrin glue group, and in four eyes (10.5%) in the suture group (P ¼ 0.33). The rates of conjunctival recurrence (grade 3) were 21.9% (seven eyes) and 23.7% (nine eyes) in the fibrin glue and suture groups, respectively (P ¼ 0.38). Conclusions Amniotic membrane grafts can be successfully attached without any major complication in patients undergoing pterygium surgery. In addition, it is effective in shortening the duration of surgery and preventing post-operative discomfort. Although there seems to be no difference in the recurrence rates and cosmetic outcomes between both groups, neither technique represents best results.

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Section: Discussionsupporting

confidence: 82%

“…2 Commonly, 8-0 vicryl or 10-0 nylon sutures are used to fixate the amniotic membrane to the episcleral tissues and surrounding conjunctiva.…”

Section: Introductionmentioning

confidence: 99%

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

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“…The amniotic membrane has been already applied in medicine to treat burning lesions and in surgical wounds to cover tissue. Additionally, it has been used as a dressing or substrate for epithelial growth to manage several conditions of the ocular surface [5][6][7] . The amniotic membrane, or amnion, is the most interior layer of the fetus membranes.…”

Section: Introductionmentioning

confidence: 99%

Bone density of defects treated with lyophilized amniotic membrane versus collagen membrane: a tomographic and histomorfogenic study in rabbit´s femur

et al. 2014

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Abstract:The aim of this study was to compare bone density of bone defects treated with lyophilizated amniotic membrane (LAM) and collagen membrane (CM) at three and five weeks. Two bone defects of 4mm in diameter and 6mm deep were created in left distal femoral diaphysis of New Zealand rabbits (n=12). The animals were randomly divided into two groups. One of the defects was covered with lyophilized amniotic membrane (Rosa Chambergo Tissue Bank/National Institute of Child Health-IPEN, Lima, Peru) or collagen membrane (Dentium Co, Seoul, Korea). The second one was left uncovered (NC). The rabbits were killed after three and five weeks (three rabbits/period). The results showed a high bone density and defect repair by new bone. The tomographic study revealed that bone density of the defects treated with LAM at three weeks was equivalent to the density obtained with CM and higher density compared with NC (p<0.05). At five weeks, the bone density obtained with LAM was more than the density obtained with CM and NC (p<0.05). The histomorphometric study showed no significant differences between LAM and CM at three and five weeks (p>0.05). The results show that the lyophilizated amniotic membrane provides equal or higher bone density than the collagen membrane.

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“…10,12,13 The main reasons for using amniotic membrane transplantation on conjunctival defects are the positive effects on reepithelialization and inhibition of postoperative inflammation, neovascularisation, and fibrosis. 17 Pirouzian et al 11 reported that the purpose of amniotic membrane transplantation was primarily to achieve a volumetric filling of the stromal and epithelial defect after the removal of a limbal dermoid. They also Eye anticipated reduced scarring due to faster reepithelialization.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of corneal limbal dermoids: retrospective study of different techniques and use of Mitomycin C

Lang¹,

Böhringer²,

Reinhard³

2014

Eye

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Purpose We retrospectively studied the efficacy and safety of different surgical approaches to treating pediatric limbal dermoids with regard to intra and postoperative complications. Methods The data of 12 consecutive patients (14 eyes), who underwent monocentric surgery of a limbal demoid in the past 9 years, were retrospectively analyzed for intra and postoperative complications. Group one consists of eleven eyes: seven eyes with a bare-sclera deep lamellar excision of the dermoid and four eyes with an additional amniotic membrane transplantation subsequent to excision. Group two consists of three eyes: two eyes treated with Mitomycin C 0.02% over 2 min following the excision, and one eye treated with Mitomycin C and amniotic membrane transplantation after removal of the dermoid. Follow-up ranged from 2 to 53 months (median 17 months). Results Intraoperative complications did not occur in any of the patients. Postoperatively, all patients showed corneal reepithelialization within a week. Limbal stem cell deficiency with a pseudopterygium developed in four eyes, one treated with bare-sclera excision and the others with amniotic membrane transplantation. One pseudopterygium had to be removed surgically because of visual acuity deterioration. Not a single eye treated with Mitomycin C developed a pseudopterygium. Conclusions The transplantation of amniotic membrane following removal of a limbal dermoid cannot prevent the occurrence of a pseudopterygium. However, the use of Mitomycin C seems to have a protective effect.

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Amniotic membrane use in ophthalmology

Cited by 177 publications

References 50 publications

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Bone density of defects treated with lyophilized amniotic membrane versus collagen membrane: a tomographic and histomorfogenic study in rabbit´s femur

Surgical management of corneal limbal dermoids: retrospective study of different techniques and use of Mitomycin C

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