2003
DOI: 10.1046/j.1365-2990.2003.00473.x
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AMOG/β2 and glioma invasion: does loss of AMOG make tumour cells run amok?

Abstract: The beta2 subunit of Na,K-ATPase, initially described as adhesion molecule on glia (AMOG), has been shown to mediate neurone-astrocyte adhesion as well as neural cell migration in vitro. We have investigated the expression of AMOG/beta2 in human gliomas and its effect on glioma cell adhesion and migration. Compared to normal astrocytes of human brain, AMOG/beta2 expression levels of neoplastic astrocytes were down-regulated in biopsy specimens and inversely related to the grade of malignancy. One rat and four … Show more

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Cited by 40 publications
(35 citation statements)
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“…In these studies, ouabain-induced inhibition increased the expression of a number of growthrelated genes and stimulated nonproliferative cell growth (hypertrophy). Similarly, Senner et al (60) showed that AMOG expression in AMOG-deficient C6 glioma cells did not reduce cell proliferation. Instead, AMOG expression increased cell adhesion and decreased cell migration on Matrigel.…”
Section: Discussionmentioning
confidence: 91%
See 1 more Smart Citation
“…In these studies, ouabain-induced inhibition increased the expression of a number of growthrelated genes and stimulated nonproliferative cell growth (hypertrophy). Similarly, Senner et al (60) showed that AMOG expression in AMOG-deficient C6 glioma cells did not reduce cell proliferation. Instead, AMOG expression increased cell adhesion and decreased cell migration on Matrigel.…”
Section: Discussionmentioning
confidence: 91%
“…Gene expression profiling of neoplastic and nonneoplastic astrocytes from these mice revealed that another adhesion molecule expressed in the brain, adhesion molecule on glia (AMOG), is downregulated in neoplastic cells (25). Similarly, Senner et al (60) showed that AMOG expression was decreased in neoplastic cells in human glioma specimens relative to normal astrocytes, and that this decrease in expression correlated with increasing tumor grade. These observations suggested that AMOG may play a role in regulating glioma growth and proliferation.…”
mentioning
confidence: 94%
“…Decreased expression of the ␤ 1 subunit is associated with cancer (reviewed in Ref. 20), whereas abnormalities in expression and distribution of the ␤ 2 subunit are linked to glioma and epilepsy (21)(22)(23)(24).…”
mentioning
confidence: 99%
“…relation to neuroprotection/regeneration or trophic/memory), and references. Details of abbreviated references in the table:[25,27,29,33,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. For some transcripts the description of function is partially retrieved from the Medical subjects heading (MESH) at http://www.ncbi.nlm.nih.gov/pubmed.…”
mentioning
confidence: 99%