Amorphous calcium phosphate, hydroxyapatite and poly( d , l -lactic acid) composite nanofibers: Electrospinning preparation, mineralization and in vivo bone defect repair

Zhang, Hao; Fu, Qiwei; Sun, Tuan-Wei; Chen, Feng; Qi, Chao; Wu, Jin; Cai, Zhuyun; Qian, Qirong

doi:10.1016/j.colsurfb.2015.08.015

Cited by 81 publications

(46 citation statements)

References 40 publications

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“…While thin radio-frequency magnetron sputter deposited nano-hydroxyapatite films were formed on a Fe-tricalcium phosphate bioceramic composite, obtained by conventional powder injection moulding technique [113], amorphous calcium phosphate nanospheres and hydroxyapatite nanorods were prepared and hybridized with polylactic acid to fabricate the composite nanofibers through electrospinning [114].…”

Section: The Inorganic Bone Matrix: Hydroxyapatitementioning

confidence: 99%

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

et al. 2016

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Surface modification of dental implants is a key process in the production of these medical devices, and especially titanium implants used in the dental practice are commonly subjected to surface modification processes before their clinical use. A wide range of treatments, such as sand blasting, acid etching, plasma etching, plasma spray deposition, sputtering deposition and cathodic arc deposition, have been studied over the years in order to improve the performance of dental implants. Improving or accelerating the osseointegration process is usually the main goal of these surface processes, but the improvement of biocompatibility and the prevention of bacterial adhesion are also of considerable importance. In this review, we report on the research of the recent years in the field of surface treatments and coatings deposition for the improvement of dental implants performance, with a main focus on the osseointegration acceleration, the reduction of bacterial adhesion and the improvement of biocompatibility.

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Section: The Inorganic Bone Matrix: Hydroxyapatitementioning

confidence: 99%

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

et al. 2016

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“…[13][14][15] Nanostructured CaP materials with high biocompatibility are usually added in the polymer solution to modify the electrospun composite nanofibers. [16][17][18] For example, hydroxyapatite (HA) and anti-inflammatory drugs can be incorporated into polycaprolactone fibers by electrospinning, achieving sustained drug release and mineralization. 19 The CaP material with amorphous calcium phosphate (ACP) phase exists in native bone tissue, which is an intermediate phase in the HA formation process and displays good bioactivity.…”

Section: Fu Et Almentioning

confidence: 99%

“…[20][21][22] Therefore, the electrospun ACP-containing nanofibers may have potential applications in the studies of mineralization and bone repair/tissue engineering. 17,23 As a major category of drugs, water-soluble drugs can be easily dissolved in aqueous solution and utilized by patients, and play important roles in the biomaterial studies. Many strategies and technologies have been developed to promote cell adhesion/growth, osteointegration with the host tissue, and bone growth using water-soluble molecules (eg, growth factors and cytokines).…”

Section: Fu Et Almentioning

confidence: 99%

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

Fu¹,

Zi²,

Xu³

et al. 2016

IJN

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Calcium phosphate-based biomaterials have been well studied in biomedical fields due to their outstanding chemical and biological properties which are similar to the inorganic constituents in bone tissue. In this study, amorphous calcium phosphate (ACP) nanoparticles were prepared by a precipitation method, and used for preparation of ACP-poly( d , l -lactic acid) (ACP-PLA) nanofibers and water-soluble drug-containing ACP-PLA nanofibers by electrospinning. Promoting the encapsulation efficiency of water-soluble drugs in electrospun hydrophobic polymer nanofibers is a common problem due to the incompatibility between the water-soluble drug molecules and hydrophobic polymers solution. Herein, we used a native biomolecule of lecithin as a biocompatible surfactant to overcome this problem, and successfully prepared water-soluble drug-containing ACP-PLA nanofibers. The lecithin and ACP nanoparticles played important roles in stabilizing water-soluble drug in the electrospinning composite solution. The electrospun drug-containing ACP-PLA nanofibers exhibited fast mineralization in simulated body fluid. The ACP nanoparticles played the key role of seeds in the process of mineralization. Furthermore, the drug-containing ACP-PLA nanofibers exhibited sustained drug release which simultaneously occurred with the in situ mineralization in simulated body fluid. The osteoblast-like (MG63) cells with spreading filopodia were well observed on the as-prepared nanofibrous mats after culturing for 24 hours, indicating a high cytocompatibility. Due to the high biocompatibility, sustained drug release, and fast mineralization, the as-prepared composite nanofibers may have potential applications in water-soluble drug loading and release for tissue engineering.

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“…[3][4][5] Hydroxyapatite (HAP; Ca 10 (PO 4 ) 6 (OH) 2 ), a major inorganic component of biological hard tissues such as bone and tooth, has been widely investigated for its application in bone tissue engineering owing to its excellent biocompatibility and biodegradability. [6][7][8][9] For example, Bhumiratana et al 10 explored the incorporation of silk sponge matrices with HAP microparticles to generate highly osteogenic composite scaffolds, which could induce in vitro bone formation. HAP embedded in silk sponges significantly enhanced the osteoconductive activity of the scaffolds, indicating that HAP has an outstanding bioactivity and is thus an ideal biomaterial for application in bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

Zhou

Chen

et al. 2017

IJN

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Hydroxyapatite (HAP; Ca 10 (PO 4 ) 6 (OH) 2 ) and whitlockite (WH; Ca 18 Mg 2 (HPO 4 ) 2 (PO 4 ) 12 ) are widely utilized in bone repair because they are the main components of hard tissues such as bones and teeth. In this paper, we synthesized HAP and WH hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through microwave-assisted hydrothermal method. Then, we prepared HAP/chitosan and WH/chitosan composite membranes to evaluate their biocompatibility in vitro and prepared porous HAP/chitosan and WH/chitosan scaffolds by freeze drying to compare their effects on bone regeneration in calvarial defects in a rat model. The experimental results indicated that the WH/chitosan composite membrane had a better biocompatibility, enhancing proliferation and osteogenic differentiation ability of human mesenchymal stem cells than HAP/chitosan. Moreover, the porous WH/chitosan scaffold can significantly promote bone regeneration in calvarial defects, and thus it is more promising for applications in tissue engineering such as calvarial repair compared to porous HAP/chitosan scaffold.

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Amorphous calcium phosphate, hydroxyapatite and poly( d , l -lactic acid) composite nanofibers: Electrospinning preparation, mineralization and in vivo bone defect repair

Cited by 81 publications

References 40 publications

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

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