Amosite as a Cause of Lung Cancer and Mesothelioma in Humans<sup>*</sup>

McCullagh, S. F.

doi:10.1093/occmed/30.4.153

Cited by 6 publications

(2 citation statements)

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“…Piperazine and thiazolidin‐4‐one nucleus derivatives occupy a unique place in the field of organic and medicinal chemistry. Piperazine is a six membered heterocyclic motif, piperazine‐containing drug molecules with less side effects and there is no evidence of acute toxicity in humans and thiazolidin‐4‐one is considered as a heterocyclic moiety with presence of sulfur atom in five membered ring 14–15 . These derivatives exhibit wide spread of biological applications like anticonvulsant, 16 antimicrobial, 17 antifungal, 18 anti‐inflammatory, 19 tyrosine kinase inhibitory, 20 HIV‐RT inhibitory, 21 anti‐mycobacterial, 22 antihypertensive, 23 and anti‐proliferative activities 24 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial agents of thiazolidinone derivatives from benzocyclohepetenone

Jilla

Kolluri

Bujji

et al. 2020

Journal of Heterocyclic Chem

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A series of benzosuberone coupled piperazin‐1‐yl thiazolidin‐4‐one derivatives 6a‐j were synthesized from 3‐(2‐[9‐chloro‐2,3‐dimethyl‐6,7‐dihydro‐5H‐benzo[7]annulen‐8‐yl]‐4‐oxothiazolidin‐3‐yl)propanoic acid (4) and substituted piperazines/secondary amines 5a‐j using 1‐hydroxy benzotriazole, 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride and triethyl amine in good yields and their structures were characterized by 1H NMR, 13C NMR, IR, and Mass spectra. The newly synthesized compounds were evaluated for their antimicrobial activity against bacterial strains and a fungal strain. Compounds 6f and 6g were indicated promising and broad spectrum antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial agents of thiazolidinone derivatives from benzocyclohepetenone

Jilla

Kolluri

Bujji

et al. 2020

Journal of Heterocyclic Chem

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“…However, there is still controversy about the gradient of pathogenicity of these three types of asbestos. Several epidemiological studies on human populations which have been exposed to one type of fiber have persuaded many people that crocidolite (7)(8)(9), and perhaps also amosite (10,11), is much more carcinogenic towards the pleura than chrysotile (12).…”

Section: Introductionmentioning

confidence: 99%

Biological in vitro and in vivo responses of chrysotile versus amphiboles.

Bignon¹,

Jaurand²

1983

Environ Health Perspect

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Although all commercial forms of asbestos have been demonstrated to be carcinogenic in animals, so far epidemiological data are controversial concerning what asbestos types are the most carcinogenic and fibrogenic in humans. In order to understand the early cellular events induced by fibrous particles, different in vitro studies (hemolysis, release of enzymes by macrophages, assays on cell culture systems) have been carried out in several laboratories; most of these studies have shown that cell and subcellular in vitro responses were different depending on fiber types: chrysotile versus amphiboles. This presentation compares the results of different laboratories with our data obtained by using a model which modifies the chemistry of the fibers by acid treatment. The acid-leached chrysotile and acid-treated amphibole fibers showed different biological responses in several in vitro systems used in comparison to unleached fibers. These differences in the in vitro reactivity were related to the chemical state of the fibers and might explain the differences in their effects in animals after intrapleural injection as assessed by the percentage of mesothelioma, the latency period, the survival time and the degree of pleural fibrosis. The carcinogenic effect of the fibers is discussed in relation of their in vitro inflammatory or cytotoxic responses.

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