The History of Mesothelioma

Smith, Deborah Deutsch

doi:10.1007/0-387-28274-2_1

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Combined anticancer treatment results had to be interpreted in a matrix in which many shades of a grey zone replaced the former black and white division line between the categories of curative and palliative treatments. Mesothelioma thus far as a neglected emerging entity posed as the third element (42) The four main factors, and several others not independent from one another, all in the context of the pleural space and underlying lung were in need of an efficient therapeutical solution. One of the answers was HITHOC.…”

Section: Crossroadmentioning

confidence: 99%

Narrative review of theoretical considerations regarding HITHOC between past and future

Molnár¹,

Drozgyik²

2021

Ann Transl Med

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Hyppocrates constructed the medicines-surgery-energy triangle which includes all therapeutical modalities. Hyperthermic intraoperative chemotherapy (HITHOC) is a synergy-based single stage multimodality treatment encompassing the locoregional manifestation of the systemic malignant process.Pleural space, thermal effect, lavage/irrigation and chemotherapy represent the basic science ports of the network hub: HITHOC. The malignant transformation and process of the pleural surface (and underlying lung) challenges space management and tissue control. Thermotherapy without local chemotherapy is insufficient, similar to the normothermic local irrigation aligned with anticancer agents. The local administration of combined heat-transfer fluid and chemotherapy with or without subsequent surgical removal offers reasonable outcome in extensive primary pleural neoplasms (malignant mesothelioma), advanced (> Stage IIIA) NSCLC, functionally inoperable lung cancer and pleural carcinosis from extrathoracic malignancies. Measured by symptom-free survival and the quality of life, HITHOC in its present form, offers a modest yet fully substantiated solution. HITHOC in combination with the local application of targeted therapy and/or immunotherapy administered in the pleural space are currently under investigation. Additional development including new acting substances, their solvents and the means regarding surgical delivery and anesthesiology techniques are sign posts up ahead. Level 2 evidence are required in order to stepping up the recommendation levels, rewriting protocols and guidelines, in which HITHOC earns its revered position in the decision making process it deserves.

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Section: Crossroadmentioning

confidence: 99%

Narrative review of theoretical considerations regarding HITHOC between past and future

Molnár¹,

Drozgyik²

2021

Ann Transl Med

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“…Of course, not all of this mortality is attributable to criminal activity, and criminal convictions for asbestos-related offences have been notoriously difficult to obtain. However, the health risks of asbestos exposure were apparent to industry insiders and regulators as early as the 1930s (Merewether and Price 1930), and its cancer risks well established by the 1960s (Smith 2005), yet significant exposure continued until the 1980s in most developed countries and continues today in much of the developing world (Røe and Stella 2015). There is evidence that criminal negligence and other criminal activities have contributed substantially to asbestos exposures and thus to asbestos-related deaths (e.g., United States vs. Thorn 2013; McCulloch and Tweedale 2008; Reuters 2013).…”

Section: The Deadly Costs Of White-collar Crimementioning

confidence: 99%

Biomarkers for the Rich and Dangerous: Why We Ought to Extend Bioprediction and Bioprevention to White-Collar Crime

Zohny

Douglas

Savulescu

2018

Criminal Law, Philosophy

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There is a burgeoning scientific and ethical literature on the use of biomarkers—such as genes or brain scan results—and biological interventions to predict and prevent crime. This literature on biopredicting and biopreventing crime focuses almost exclusively on crimes that are physical, violent, and/or sexual in nature—often called blue-collar crimes—while giving little attention to less conventional crimes such as economic and environmental offences, also known as white-collar crimes. We argue here that this skewed focus is unjustified: white-collar crime is likely far costlier than blue-collar crime in money, health, and lives lost. Moreover, attempts to biopredict and bioprevent blue-collar crime may entail adopting potentially unfair measures that target individuals who are already socio-economically disadvantaged, thus compounding pre-existing unfairness. We argue, therefore, that we ought to extend the study of bioprediction and bioprevention to white-collar crime as a means of more efficiently and fairly responding to crime. We suggest that identifying biomarkers for certain psychopathic traits, which appear to be over-represented among senior positions in corporate and perhaps political organisations, is one avenue through which this research can be broadened to include white-collar crime.

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A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes

et al. 2007

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In Cappadocia, Turkey, an unprecedented mesothelioma epidemic causes 50% of all deaths in three small villages. Initially linked solely to the exposure to a fibrous mineral, erionite, recent studies by scientists from Turkey and the United States have shown that erionite causes mesothelioma mostly in families that are genetically predisposed to mineral fibre carcinogenesis. This manuscript reports, through the eyes of one of the researchers, the resulting scientific advances that have come from these studies and the social improvements that were brought about by both the scientists and members of the Turkish Government.

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The History of Mesothelioma

Cited by 6 publications

References 36 publications

Narrative review of theoretical considerations regarding HITHOC between past and future

Narrative review of theoretical considerations regarding HITHOC between past and future

Biomarkers for the Rich and Dangerous: Why We Ought to Extend Bioprediction and Bioprevention to White-Collar Crime

A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes

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