Amount and type of alcohol and risk of dementia

Truelsen, Thomas; Thudium, Dorte; Grønbæk, Morten

doi:10.1212/01.wnl.0000031421.50369.e7

Cited by 264 publications

(174 citation statements)

References 33 publications

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“…Moderate wine consumption rather than alcohol consumption per se has been specifically associated with a lower risk of developing dementia and specifically Alzheimer's disease in studies over the past two decades [38,54,[72][73][74][77][78][79][80][81][82][83][84]. Wine consumption of up to approximately 75 mL per day improved cognition in 883 elderly subjects recruited from the Norwegian Hordaland Health Study [154].…”

Section: Relationship Of Wine To Cognitive Function and Dementiasmentioning

confidence: 99%

Wine consumption, cognitive function and dementias – A relationship?

Stockley

2016

NUA

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Abstract. Healthy cognitive function is essential for quality of life, wellbeing and independent living, and is negatively associated with dementias. A series of longitudinal and neuro-imaging studies in the elderly have shown that light to moderate wine consumption is neuro-protective although heavy or abusive alcohol consumption is neuro-toxic. A J-shaped relationship between alcohol consumption, cognitive dysfunction and risk of dementias is also observed for younger and middle aged consumers. There is also no data to suggest that long-term light to moderate alcohol consumption exacerbates age-related cognitive decline and impairment. An optimal amount of wine for neuro-protection appears to be up to 30 g alcohol daily.There are multiple plausible biological mechanisms in various animal models, in vitro and in vivo for wine-derived phenolic compounds which go beyond their antioxidant activity and attenuation of oxidative stress.

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Section: Relationship Of Wine To Cognitive Function and Dementiasmentioning

confidence: 99%

Wine consumption, cognitive function and dementias – A relationship?

Stockley

2016

NUA

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“…Resveratrol reduces infection-related neuroinflammation and attenuates working memory deficits in aged mice, suggesting that resveratrol may be useful for mitigating acute cognitive disorders in elderly individuals with an infection (90). Furthermore, although moderate red wine intake has been associated with reduced incidence of Alzheimer's disease and other forms of dementia (91)(92)(93), clear evidence regarding resveratrol's role is still lacking (94,95). Thus, although resveratrol may not be able to extend overall life span in healthy individuals, it will be important to assess the degree to which it might be able to increase quality of life among the overweight and the elderly individuals by mitigating some of the negative effects of an unhealthy lifestyle.…”

Section: Sirtuin Activatorsmentioning

confidence: 99%

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Minor

Allard

Younts

et al. 2010

The Journals of Gerontology Series A: Biological Sciences and M

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The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, underscoring the need for the development of alternative interventions to successfully treat metabolic disorders and enhance life span and health span. Using calorie restriction (CR)-which is well known to improve both health and longevity in controlled studies-as their benchmark, gerontologists are coming closer to identifying dietary and pharmacological therapies that may be applicable to aging humans. This review covers some of the more promising interventions targeted to affect pathways implicated in the aging process as well as variations on classical CR that may be better suited to human adaptation.

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“…A number of dietary factors such as saturated fatty acids, higher calorie intake, and excessive alcohol (7) have been reported to increase the risk of dementia and AD (8). In particular, a number of studies have shown the close association of alcoholic consumption and dementia, although the exact mechanisms are still not known (9)(10)(11)(12)(13). Studies have been shown that frequent alcohol uptake by rats can cause mitochondrial dysfunction in neurons, leading to neurodegeneration (14).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic alcohol consumption on expression levels of APP and Aβ-producing enzymes

Kim¹,

Jeong²,

Yang³

et al. 2011

BMB Reports

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Chronic alcohol consumption contributes to numerous diseases, including cancers, cardiovascular diseases, and liver cirrhosis. Epidemiological studies have shown that excessive alcohol consumption is a risk factor for dementia. Along this line, Alzheimer's disease (AD) is the most common form of dementia and is caused by the accumulation of amyloid-β (Aβ plaques in neurons. In this study, we hypothesized that chronic ethanol consumption is associated with pathological processing of APP in AD. To investigate the relationship between chronic alcohol consumption and Aβ production, brain samples from rats fed an alcohol liquid diet for 5 weeks were analyzed. We show that the expression levels of APP, BACE1, and immature nicastrin were increased in the cerebellum, hippocampus, and striatum of the alcohol-fed group compared to the control group. Total nicastrin and PS1 levels were induced in the hippocampus of alcohol-fed rats. These data suggest that the altered expression of APP and Aβ-producing enzymes possibly contributes to the chronic alcohol consumption-mediated pathogenesis of AD. [BMB reports 2011; 44(2): 135-139]

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Amount and type of alcohol and risk of dementia

Abstract: Monthly and weekly intake of wine is associated with a lower risk of dementia. The results do not indicate that people should start drinking or increase wine consumption to avoid dementia, but instead suggest that certain substances in wine may reduce the occurrence of dementia.

Cited by 264 publications

References 33 publications

Wine consumption, cognitive function and dementias – A relationship?

Wine consumption, cognitive function and dementias – A relationship?

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Effects of chronic alcohol consumption on expression levels of APP and Aβ-producing enzymes

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