Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

Zegan, Georgeta; Anistoroaei, Daniela; Cărăuşu, Elena Mihaela; Cernei, Eduard Radu; Golovcencu, Loredana

doi:10.37358/mp.19.2.5193

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Chitosan nanoparticles (below referred to as Cs NPs) are obtained by coagulation of the polymer from solutions of various concentrations in a treatment with acetic acid and cross-linking with sodium tripolyphosphate to form a polymer complex. The nanoparticles of chitosan—which is a biologically active, biocompatible, and biodegradable polymer—are used as carriers for targeted delivery of drugs such as doxycycline [ 62 ], amoxicillin and clavulanic acid [ 63 ], and simvastatin [ 64 ] to damaged dental tissue, which ensure prolonged drug release and thus decrease the therapeutic dose.…”

Section: Nanoparticles With Antimicrobial Action Used In Dental Mater...mentioning

confidence: 99%

Polymeric Dental Nanomaterials: Antimicrobial Action

et al. 2022

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This review aims to describe and critically analyze studies published over the past four years on the application of polymeric dental nanomaterials as antimicrobial materials in various fields of dentistry. Nanoparticles are promising antimicrobial additives to restoration materials. According to published data, composites based on silver nanoparticles, zinc(II), titanium(IV), magnesium(II), and copper(II) oxide nanoparticles, chitosan nanoparticles, calcium phosphate or fluoride nanoparticles, and nanodiamonds can be used in dental therapy and endodontics. Composites with nanoparticles of hydroxyapatite and bioactive glass proved to be of low efficiency for application in these fields. The materials applicable in orthodontics include nanodiamonds, silver nanoparticles, titanium(IV) and zinc(II) oxide nanoparticles, bioactive glass, and yttrium(III) fluoride nanoparticles. Composites of silver nanoparticles and zinc(II) oxide nanoparticles are used in periodontics, and nanodiamonds and silver, chitosan, and titanium(IV) oxide nanoparticles are employed in dental implantology and dental prosthetics. Composites based on titanium(IV) oxide can also be utilized in maxillofacial surgery to manufacture prostheses. Composites with copper(II) oxide nanoparticles and halloysite nanotubes are promising materials in the field of denture prosthetics. Composites with calcium(II) fluoride or phosphate nanoparticles can be used in therapeutic dentistry for tooth restoration.

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Section: Nanoparticles With Antimicrobial Action Used In Dental Mater...mentioning

confidence: 99%

Polymeric Dental Nanomaterials: Antimicrobial Action

et al. 2022

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Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

et al. 2021

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The intensive development of micro- and nanotechnologies in recent years has offered a wide horizon of new possibilities for drug delivery in dentistry. The use of polymeric drug carriers turned out to be a very successful technique for formulating micro- and nanoparticles with controlled or targeted drug release in the oral cavity. Such innovative strategies have the potential to provide an improved therapeutic approach to prevention and treatment of various oral diseases not only for adults, but also in the pediatric dental practice. Due to their biocompatibility, biotolerance and biodegradability, naturally occurring polysaccharides like chitosan, alginate, pectin, dextran, starch, etc., are among the most preferred materials for preparation of micro- and nano-devices for drug delivery, offering simple particle-forming characteristics and easily tunable properties of the formulated structures. Their low immunogenicity and low toxicity provide an advantage over most synthetic polymers for the development of pediatric formulations. This review is focused on micro- and nanoscale polysaccharide biomaterials as dental drug carriers, with an emphasis on their potential application in pediatric dentistry.

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Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

Cited by 3 publications

References 13 publications

Polymeric Dental Nanomaterials: Antimicrobial Action

Polymeric Dental Nanomaterials: Antimicrobial Action

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

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